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The Riddle of Sex: Biological Theories of Sexual Difference in the Early Twentieth-Century

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Abstract

At the turn of the twentieth century, biologists such as Oscar Riddle, Thomas Hunt Morgan, Frank Lillie, and Richard Goldschmidt all puzzled over the question of sexual difference, the distinction between male and female. They all offered competing explanations for the biological cause of this difference, and engaged in a fierce debate over the primacy of their respective theories. Riddle propounded a metabolic theory of sex dating from the late-nineteenth century suggesting that metabolism lay at the heart of sexual difference. Thomas Hunt Morgan insisted on the priority of chromosomes, Frank Lillie emphasized the importance of hormones, while Richard Goldschmidt supported a mixed model involving both chromosomes and hormones. In this paper, I will illustrate how the older metabolic theory of sex was displaced when those who argued for the relatively newer theories of chromosomes and hormones gradually formed an alliance that accommodated each other and excluded the metabolic theory of sex. By doing so, proponents of chromosomes and hormones established their authority over the question of sexual difference as they laid the foundations for the new disciplines of genetics and endocrinology. Their debate raised urgent questions about what constituted sexual difference, and how scientists envisioned the plasticity and controllability of this difference. These theories also had immediate political and cultural consequences at the turn of the twentieth century, especially for the eugenic and feminist movements, both of which were heavily invested in knowledge of sex and its determination, ascertainment, and command.

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References

  • Allen, Garland E. 1966. “Thomas Hunt Morgan and the Problem of Sex Determination, 1903–1910.” Proceedings of the American Philosophical Society 110(1): 48–57.

    Google Scholar 

  • Allen, Garland E. 1974. “Opposition to the Mendelian-Chromosome Theory: The Physiological and Developmental Genetics of Richard Goldschmidt.” Journal of the History of Biology 7: 49–92.

    Article  Google Scholar 

  • Allen, Garland E. 1978. Thomas Hunt Morgan: The Man and His Science. Princeton: Princeton University Press.

    Google Scholar 

  • Allen, Garland E. 1997. “The Double-Edged Sword of Genetic Determinism: Social and Political Agendas in Genetic Studies of Homosexuality, 1940–1994.” Vernon A. Rosario (ed.), Science and Homosexualities. New York: Routledge, pp. 242–270.

    Google Scholar 

  • Anon. 1913. Sex Control Sure. The Washington Post, October 23.

  • Anon. 1914a. Sex Control Secret in Animals Solved. New York Times, April 1.

  • Anon. 1914b. The Washington Post, April 3.

  • Anon. 1914c. Can Control Sex by Science’s Use. Chicago Daily Tribune, June 20.

  • Anon. 1914d. Artificial Control of Sex Promised. The Atlanta Constitution, June 20.

  • Anon. 1927a. Tells of Progress in Sex Research. New York Times, March 4.

  • Anon. 1927b. Athletics Held Bad for Women. Los Angeles Times, March 5.

  • Anon. 1927c. Finds Modern Life Lessens Sex Fixity, New York Times, May 6.

  • Anon. 1932. Discovery of Milk Hormone Held Aid to Health of Young. The Washington Post, August 8.

  • Anon. 1933. Scientists Discover New Type of Hormone. The Washington Post, December 29.

  • Anon. 1937. Sex Selection. Los Angeles Times, January 15.

  • Anon. 1938. Science: Prolactin. Time, May 2. http://www.time.com/time/magazine/article/0,9171,848923,00.html.

  • Anon. 1939a. LIFE: Time Covers – The 30S – Hosted by Google. http://images.google.com/hosted/life/f?q=oscar+riddle&prev=/images%3Fq%3Doscar%2Briddle%26um%3D1%26hl%3Den%26safe%3Doff%26client%3Dfirefox-a%26sa%3DN%26rls%3Dorg.mozilla:en-US:official%26tbs%3Disch:1&imgurl=1cbfd0d1211e2a73.

  • Anon. 1939b. Science: Pituitary Master. Time, January 9. http://www.time.com/time/magazine/article/0,9171,771303,00.html.

  • Baxter, Alice. 1976. “Edmund B. Wilson as a Preformationist: Some Reasons for His Acceptance of the Chromosome Theory.” Journal of the History of Biology 9(1): 29–57.

    Article  Google Scholar 

  • Bederman, Gail. 1996. Manliness & Civilization: A Cultural History of Gender and Race in the United States, 1880–1917. Chicago: University of Chicago Press.

    Google Scholar 

  • Borell, Merriley. 1976. “Organotherapy, British Physiology, and Discovery of the Internal Secretions.” Journal of the History of Biology 9(2): 235–268.

    Article  Google Scholar 

  • Brush, Stephen G. 1978. “Nettie M. Stevens and the Discovery of Sex Determination by Chromosomes.” Isis 69(2): 163–172.

    Article  Google Scholar 

  • Carlson, Elof A. 2004. Mendel’s Legacy: The Origin of Classical Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.

    Google Scholar 

  • Clarke, Adele. 1998. Disciplining Reproduction: Modernity, American Life Sciences, and “the Problems of Sex”. Berkeley: University of California Press.

    Google Scholar 

  • Conway, Jill. 1970. “Stereotypes of Femininity in a Theory of Sexual Evolution.” Victorian Studies 14(1): 47–62.

    Google Scholar 

  • Corner, George. 1974. Oscar Riddle (1877–1968). In Biographical Memoir. Washington, DC: National Academy of Sciences.

    Google Scholar 

  • Crew, F. A. E. 1923. “Studies in Intersexuality.–II. Sex-Reversal in the Fowl.” Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character 95(667): 256–278.

    Google Scholar 

  • Danforth, Charles Haskell. 1932. “The Interrelation of Genic and Endocrinic Factors in Sex.’ Edgar Allen (ed.), Sex And Internal Secretions: A Survey of Recent Research. Baltimore, MD: The Williams and Wilkins Company, pp. 12–53.

    Google Scholar 

  • Dietrich, Michael R. 1995. “Richard Goldschmidt’s ‘Heresies’ and the Evolutionary Synthesis.” Journal of the History of Biology 28: 431–461.

    Article  Google Scholar 

  • Dietrich, Michael R. 2000. “Of Moths and Men: Theo Lang and the Persistence of Richard Goldschmidt’s Theory of Homosexuality, 1916–1960.” History and Philosophy of the Life Sciences 22: 219–247.

    Google Scholar 

  • Dietrich, Michael R. 2008. “Striking the Hornet’s Nest: Richard Goldschmidt’s Rejection of the Particulate Gene.” Oren Harman and Michael R. Dietrich (eds.), Rebels, Mavericks, and Heretics in Biology. New Haven, CT: Yale University Press, pp. 119–136.

    Google Scholar 

  • Dreger, Alice Domurat. 1998. Hermaphrodites and the Medical Invention of Sex. Cambridge, MA: Harvard University Press.

    Google Scholar 

  • Fausto-Sterling, Anne. 2000. Sexing the Body: Gender Politics and the Construction of Sexuality. 1st ed. New York: Basic Books.

    Google Scholar 

  • Garbedian, H. Gordon. 1929. Science Pictures a Superman of Tomorrow. New York Times, December 8.

  • Geddes, Patrick and Thomson, J. Arthur. 1889. The Evolution of Sex. Contemporary Science Series. London: Walter Scott.

  • Geddes, Patrick and J. Arthur Thomson. 1901. The Evolution of Sex. Rev. Ed. Contemporary Science Series. London: Walter Scott.

  • Gerould, John. 1923. “Inheritance of White Wing Color, A Sex-Limited (Sex-Controlled) Variation in Yellow Pierid Butterflies.” Genetics 8: 495–551.

    Google Scholar 

  • Gilbert, Scott F. 1978. “The Embryological Origins of the Gene Theory.” Journal of the History of Biology 11(2): 307–351.

    Article  Google Scholar 

  • Gilbert, Scott F. 1987. “In Friendly Disagreement: Wilson, Morgan, and the Embryological Origins of the Gene Theory.” American Zoologist 27(3): 797–806.

    Google Scholar 

  • Goldschmidt, Richard. 1916a. “Experimental Intersexuality and the Sex-Problem.” The American Naturalist 50(600): 705–718.

    Google Scholar 

  • Goldschmidt, Richard. 1916b. “Genetic Factors and Enzyme Reaction.” Science 43(1099), New Series: 98–100.

  • Goldschmidt, Richard. 1916c. “A Preliminary Report on Further Experiments in Inheritance and Determination of Sex.” Proceedings of the National Academy of Sciences of the United States of America 2(1): 53–58.

  • Goldschmidt, Richard. 1916d. “Die biologischen Grundlagen der konträren Sexualität und des Hermaphroditismus beim Menschen.” Archiv für Rassen und Gesellschafts Biologie 12: 1–14.

    Google Scholar 

  • Goldschmidt, Richard. 1917. “Intersexuality and the Endocrine Aspect of Sex.” Endocrinology 1: 433–456.

    Article  Google Scholar 

  • Goldschmidt, Richard. 1923. The Mechanism and Physiology of Sex Determination. Trans. William J. Dakin. London: Methuen & Co., Ltd.

  • Goldschmidt, Richard. 1926. “The Quantitative Theory of Sex.” Science 64(1656), New Series: 299–300.

  • Goldschmidt, Richard. 1927. “The Quantitative Theory of Sex.” Science 65(1694), New Series: 596–597.

  • Goldschmidt, Richard. 1931. Die Sexuellen Zwischenstufen. Berlin: Julius Springer.

    Google Scholar 

  • Hofstadter, Richard. 1944. Social Darwinism in American Thought, 1860–1915. Philadelphia: University of Pennsylvania Press.

    Google Scholar 

  • Kallmann, Franz J. 1952. “Twin and Sibship Study of Overt Male Homosexuality.” American Journal of Human Genetics 4(2): 136–146.

    Google Scholar 

  • Kevles, Daniel J. 1980. “Genetics in the United States and Great Britain, 1890–1930: A Review with Speculations.” Isis 71(3): 441–455.

    Article  Google Scholar 

  • Kevles, Daniel J. 1995. In the Name of Eugenics: Genetics and the Uses of Human Heredity. 1st edn. Cambridge, MA: Harvard University Press.

    Google Scholar 

  • Kingsland, Sharon E. 2007. “Maintaining Continuity Through a Scientific Revolution: A Rereading of E. B. Wilson and T. H. Morgan on Sex Determination and Mendelism.” Isis 98(3): 468–488.

    Article  Google Scholar 

  • Kline, Wendy. 2001. Building a Better Race: Gender, Sexuality, and Eugenics from the Turn of the Century to the Baby Boom. Berkeley, CA: University of California Press.

    Google Scholar 

  • Koehler, Christopher Scott Whiston. 1998. The Sex Problem: Thomas Hunt Morgan, Richard Goldschmidt, and the Question of Sex and Gender in the Twentieth Century. University of Florida. http://proquest.umi.com/pqdweb?did=738064331&Fmt=7&clientId=17210&RQT=309&VName=PQD.

  • Kohler, Robert E. 1994. Lords of the Fly: Drosophila Genetics and the Experimental Life. Chicago: University of Chicago Press.

    Google Scholar 

  • Laqueur, Thomas Walter. 1990. Making Sex: Body and Gender from the Greeks to Freud. Cambridge, MA: Harvard University Press.

    Google Scholar 

  • Lederman, Muriel. 1989. “Genes on Chromosomes: The Conversion of Thomas Hunt Morgan.” Journal of the History of Biology 22(1): 163–176.

    Article  Google Scholar 

  • Lillie, Frank R. 1917. “The Free-Martin: A Study of the Action of Sex Hormones in the Foetal Life of Cattle.” Journal of Experimental Zoology 23(2): 371–452.

    Article  Google Scholar 

  • Lillie, Frank R. 1923. “Supplementary Notes on Twins in Cattle.” Biological Bulletin 44(2): 47–78.

    Article  Google Scholar 

  • Lillie, Frank R. 1932. “General Biological Introduction.” Edgar Allen (ed.), Sex and Internal Secretions: A Survey of Recent Research. Baltimore, MD: The Williams and Wilkins Company, pp. 1–11.

    Google Scholar 

  • Maienschein, Jane. 1984. “What Determines Sex? A Study of Converging Approaches, 1880–1916.” Isis 75(3): 457–480.

    Article  Google Scholar 

  • Meyerowitz, Joanne J. 2002. How Sex Changed: A History of Transsexuality in the United States. Cambridge, MA: Harvard University Press.

    Google Scholar 

  • Morgan, Thomas Hunt. 1907a. Experimental Zoology. New York: The Macmillan Company.

  • Morgan, Thomas Hunt. 1907b. “Sex-Determining Factors in Animals.” Science 25(636), New Series, (March 8): 382–384.

  • Morgan, Thomas Hunt. 1909. “Recent Experiments on the Inheritance of Coat Colors in Mice.” The American Naturalist 43(512): 494–510.

    Article  Google Scholar 

  • Morgan, Thomas Hunt. 1910a. “Sex Limited Inheritance in Drosophila.” Science 32(812), New Series: 120–122.

  • Morgan, Thomas Hunt. 1910b. “Chromosomes and Heredity.” The American Naturalist 44(524): 449–496.

  • Morgan, Thomas Hunt. 1915. The Mechanism of Mendelian Heredity. New York: H. Holt and Company.

    Google Scholar 

  • Morgan, Thomas Hunt. 1928. The Theory of the Gene. New Haven: Yale University Press.

    Google Scholar 

  • Morgan, Thomas Hunt and Bridges, Calvin B. 1919. The Origin of Gynandromorphs. Contributions to the Genetics of Drosophila melanogaster. Washington, DC: Carnegie Institution of Washington, pp. 1–122.

  • Mosedale, Susan Sleeth. 1978. “Science Corrupted: Victorian Biologists Consider “The Woman Question”.” Journal of the History of Biology 11(1): 1–55.

    Article  Google Scholar 

  • Muller, H.J. 1933. “The Dominance of Economics over Eugenics.” The Scientific Monthly 37(1): 40–47.

    Google Scholar 

  • Ordover, Nancy. 2003. American Eugenics Race, Queer Anatomy, and the Science of Nationalism. Minneapolis: University of Minnesota Press.

    Google Scholar 

  • Oudshoorn, Nelly. 1990. “Endocrinologists and the Conceptualization of Sex, 1920–1940.” Journal of the History of Biology 23(2): 163–186.

    Article  Google Scholar 

  • Oudshoorn, Nelly. 1994. Beyond the Natural Body: An Archaeology of Sex Hormones. New York: Routledge.

    Book  Google Scholar 

  • Parker-Pope, Tara, 2008. Boy or Girl? The Answer May Depend on Mom’s Eating Habits – Well Blog – NYTimes.com. April. http://well.blogs.nytimes.com/2008/04/23/boy-or-girl-the-answer-may-depend-on-moms-eating-habits/?emc=eta1.

  • Pauly, Philip J. 2000. Biologists and the Promise of American Life: From Meriwether Lewis to Alfred Kinsey. Princeton, NJ: Princeton University Press.

    Google Scholar 

  • Reis, Elizabeth. 2005. “Impossible Hermaphrodites: Intersex in America, 1620–1960.” Journal of American History 92: 411–441.

    Article  Google Scholar 

  • Richmond, Marsh Leigh. 1986. Richard Goldschmidt and Sex Determination: The Growth of German Genetics, 1900–1935. Indiana University. http://proquest.umi.com/pqdweb?did=752281211&Fmt=7&clientId=17210&RQT=309&VName=PQD.

  • Riddle, Oscar. 1909. “Our Knowledge of Melanin Color Formation and Its Bearing on the Mendelian Description of Heredity.” Biological Bulletin 16(6): 316–351.

    Article  Google Scholar 

  • Riddle, Oscar. 1916. “Sex Control and Known Correlations in Pigeons.” The American Naturalist 50(595): 385–410.

    Article  Google Scholar 

  • Riddle, Oscar. 1917. “The Theory of Sex as Stated in Terms of Results of Studies on Pigeons.” Science 46(1175), New Series (July 6): 19–24.

  • Riddle, Oscar. 1924a. “Any Hereditary Character and the Kinds of Things We Need to Know About it.” The American Naturalist 58(658): 410–425.

    Google Scholar 

  • Riddle, Oscar. 1924b. “A Case of Complete Sex-Reversal in the Adult Pigeon.” The American Naturalist 58(655): 167–181.

    Google Scholar 

  • Riddle, Oscar. 1925a. Letter to Leslie Clarence Dunn, 10 April. Oscar Riddle Papers, American Philosophical Society R43, Folder Dunn.

  • Riddle, Oscar. 1925b. “The Comment on Sex in Pigeons Contained in Gerould’s Paper on Butterflies.” The American Naturalist 59(660): 79–87.

  • Riddle, Oscar. 1925c. Letter to Prof. John Thomas Scopes, 8 July. Oscar Riddle Papers, American Philosophical Society R43, Folder Scopes, John T.

  • Riddle, Oscar. 1927. “The Quantitative Theory of Sex.” Science 66(1703), New Series: 169–170.

  • Riddle, Oscar. 1932a. Biology Tomorrow Presentation Speech Notes, 29 October. Oscar Riddle Papers, American Philosophical Society R43, Folder Biology Tomorrow.

  • Riddle, Oscar. 1932b. “Metabolism and Sex.’ Edgar Allen (ed.), Sex and Internal Secretions. Baltimore, MD: The Williams and Wilkins Company, pp. 246–274.

  • Riddle, Oscar 1947. Charles Benedict Davenport (1866–1944). Biographical Memoirs. Vol. 25. Washington, D.C.: National Academy of Sciences.

  • Riddle, Oscar. 1954a. The Unleashing of Evolutionary Thought. New York: Vantage Press.

  • Riddle, Oscar. 1954b. Letter to Alfred Kinsey. Oscar Riddle Papers, American Philosophical Society R43, Folder Kinsey, Alfred.

  • Riddle, Oscar and Hrdlicka, Ales. 1927. “The Quantitative Theory of Sex.” Science 65(1675), New Series: 139–141.

  • Roosevelt, Franklin D. 1928. Letter to Oscar Riddle, 24 October. Oscar Riddle Papers, American Philosophical Society R43, Folder Roosevelt, Franklin D.

  • Russett, Cynthia Eagle. 1989. Sexual Science. Cambridge, MA: Harvard University Press.

    Google Scholar 

  • Satzinger, Helga. 2009. “Racial Purity, Stable Genes, and Sex Difference: Gender in the Making of Genetic Concepts by Richard Goldschmidt and Fritz Lenz, 1916–1936.” Susanne Heim, Carola Sachse and Mark Walker (eds.), The Kaiser Wilhelm Society Under National Socialism. New York: Cambridge University Press, pp. 145–170.

    Chapter  Google Scholar 

  • Sengoopta, Chandak. 2000. Otto Weininger: Sex, Science and Self in Imperial Vienna. Chicago: University of Chicago Press.

    Google Scholar 

  • Sengoopta, Chandak. 2006. The Most Secret Quintessence of Life: Sex, Glands, and Hormones, 1850–1950. Chicago: University of Chicago Press.

    Google Scholar 

  • Shields, Stéphanie A. 2002. Speaking from the Heart. Cambridge, UK: Cambridge University Press.

    Google Scholar 

  • Stansell, Christine. 2000. American Moderns: Bohemian New York and the Creation of a New Century. New York: Metropolitan Books.

    Google Scholar 

  • Steinach, Eugen. 1910. “Geschlechtstrieb und echt sekundäre Geschlechtmerkmale als Folge der innersekretorischen Funktion der Keimdrüse.” Zentralblatt für Physiologie 24(13): 551–566.

    Google Scholar 

  • Steinach, Eugen. 1912. “Wilkürliche Umwandlung von Säugertier-Männchen in Tiere mit ausgeprägt weiblichen Geschlechtscharakateren und weiblicher Pscyhe.” Plüger’s Archiv für Physiologie 144: 71–108.

    Article  Google Scholar 

  • Steinach, Eugen. 1913. “Feminierung von Männchen und maskulierung von Weibchen.” Zentralblatt für Physiologie 27(14): 717–723.

    Google Scholar 

  • Stevens, Nettie Maria. 1905. Studies in Spermatogenesis with Especial Reference to the “Accessory Chromosome”. Washington, DC: Carnegie Institution of Washington.

    Google Scholar 

  • Stevens, Nettie Maria. 1906. Studies in Spermatogenesis – Part II: A Comparative Study of the Heterochromosomes in Certain Species of Coleoptera, Hemiptera, and Lepidoptera, with Especial Reference to Sex Determination. Washington, DC: Carnegie Institution of Washington.

    Google Scholar 

  • Sturtevant, Alfred. 1920. “Genetic Studies on Drosophila simulans. I. Introduction. Hybrids with Drosophila melanogaster.” Genetics 5(5): 488–500.

    Google Scholar 

  • Sutton, Ransome. 1932. Sex Variations Accounted For. Los Angeles Times, November 19.

  • Terry, Jennifer. 1995. “Anxious Slippages Between “Us” and “Them:” A Brief History of the Scientific Search for Homosexual Bodies.” Jennifer Terry and Jacqueline Urla (eds.), Deviant Bodies: Critical Perspectives on Difference in Science and Popular Culture (Race, Gender, and Science). Bloomington, IN: Indiana University Press, pp. 129–169.

    Google Scholar 

  • Terry, Jennifer. 1999. An American Obsession: Science, Medicine, and Homosexuality in Modern Society. Chicago: University of Chicago Press.

    Google Scholar 

  • Watterson, Ray Leighton. 1979. “The Striking Influence of the Leadership, Research, and Teaching of Frank R. Lillie (1870–1947) in Zoology, Embryology and Other Biological Sciences.” American Zoologist 19(4): 1275–1287.

    Google Scholar 

  • Wells, H.G. 1931. The Science of Life. Garden City: Doubleday, Doran & Company, Inc.

    Google Scholar 

  • Whitman, Charles Otis. 1919. Posthumous Works of Charles Otis Whitman, Professor of Zoology in the University of Chicago, 1892–1910; Director of Marine Biological Laboratory at Woods Hole, 1888–1908. Ed. Oscar Riddle and Harvey Carr. 3 Vols. Washington: The Carnegie Institution of Washington.

  • Wilson, Edmund B. 1905a. “Studies on Chromosomes. I. The Behavior of the Idiochromosomes in Hemiptera.” Journal of Experimental Zoology 2(3): 371–405.

  • Wilson, Edmund B. 1905b. “Studies on Chromosomes. II. The Paired Microchromosomes, Idiochromosomes and Heterotropic Chromosomes in Hemiptera.” Journal of Experimental Zoology 2(4): 507–545.

  • Wilson, Edmund B. 1906. “Studies on Chromosomes. III. The Sexual Differences of the Chromosome Groups in Hemiptera, with Some Considerations on the Determination and Inheritance of Sex.” Journal of Experimental Zoology 3(1): 1–40.

    Article  Google Scholar 

  • Wilson, Edmund B. 1910. “The Chromosomes in Relation to the Determination of Sex.” Science Progress 16: 570–592.

    Google Scholar 

  • Witschi, Emil. 1932. “Sex Deviations, Inversions, and Parabiosis.” Edgar Allen (ed.), Sex and Internal Secretions: A Survey of Recent Research. Baltimore, MD: The Williams and Wilkins Company, pp. 160–245.

    Google Scholar 

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    Nathan Q. Ha

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Ha, N.Q. The Riddle of Sex: Biological Theories of Sexual Difference in the Early Twentieth-Century. J Hist Biol 44, 505–546 (2011). https://doi.org/10.1007/s10739-010-9257-1

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