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Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma

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Abstract

Background

Sporadic nonampullary duodenal epithelial tumors (NADETs) are uncommon, and thus their clinicopathological features have not been fully assessed.

Aims

In this study, we have analyzed a series of early sporadic NADETs, focusing on various immunohistological features.

Methods

We conducted a multicenter retrospective analysis of 68 patients with endoscopically resected sporadic NADETs. Associations between immunohistological features and clinicopathological features were statistically analyzed.

Results

The 68 patients consisted of 46 men (68%) and 22 women (32%) with a mean age of 60.7 ± 12.2 years (range 37–85 years). The 68 tumors were composed of 39 adenomas (57%) and 29 early-stage adenocarcinomas (43%). Duodenal adenocarcinomas were larger in size than adenomas and had papillary architecture in their pathological diagnosis with statistical significance. Duodenal adenocarcinomas also demonstrated a significantly higher expression of gastric markers (MUC5AC and MUC6) and a higher MIB-1 index. Duodenal adenomas were contrastively apt to express intestinal markers (MUC2, CDX1 and CDX2). Of the 68 cases analyzed, there were only 3 tumors positive for p53 staining, all of which were adenocarcinoma. When 7 submucosal invasive cancers and 21 intramucosal cancers were compared, submucosal invasion was positively associated with expression of MUC5AC. Also, submucosal invasion showed strong association with double-positivity of MUC5AC and MUC6.

Conclusions

Our results indicate that immunohistochemical evaluation is useful for predicting malignant potential of NADETs, especially focusing on the expression of gastrointestinal markers.

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Acknowledgments

The authors thank Dr. Yosuke Muraki from Wakayama Medical University Hospital.

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Bunkyo-ku, Hongo, Tokyo, 113-8655, Japan

    Chihiro Minatsuki, Nobutake Yamamichi, Yu Takahashi, Yosuke Tsuji, Shinya Kodashima, Yoshiki Sakaguchi, Keiko Niimi, Satoshi Ono, Mitsuhiro Fujishiro & Kazuhiko Koike

  2. Department of Diagnostic Pathology II, Fujita Health University School of Medicine, 3-6-10, Otobashi, Nakagawa-Ku, Nagoya City, Aichi, 454-8509, Japan

    Ken-ichi Inada & Kouhei Sakurai

  3. Department of Pathology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan

    Kazuya Shiogama & Yutaka Tsutsumi

  4. Kameda Medical Center Makuhari, CD-2, 1-3, Nakase, Mihama-ku, Chiba-shi, Chiba, 261-0023, Japan

    Takeshi Shimamoto

  5. Wakayama Medical University Hospital, 811-1, Kimiidera, Wakayama-shi, Wakayama, 641-8509, Japan

    Toru Niwa & Masao Ichinose

  6. NTT Medical Center Tokyo, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo, 141-0022, Japan

    Ken Ohata & Nobuyuki Matsuhashi

Authors
  1. Chihiro Minatsuki
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  2. Nobutake Yamamichi
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  3. Ken-ichi Inada
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  4. Yu Takahashi
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  7. Yosuke Tsuji
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  8. Kazuya Shiogama
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  9. Shinya Kodashima
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  10. Yoshiki Sakaguchi
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  11. Keiko Niimi
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  12. Satoshi Ono
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  13. Toru Niwa
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  14. Ken Ohata
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  15. Nobuyuki Matsuhashi
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  16. Masao Ichinose
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  17. Mitsuhiro Fujishiro
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  18. Yutaka Tsutsumi
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  19. Kazuhiko Koike
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Corresponding author

Correspondence to Nobutake Yamamichi.

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Minatsuki, C., Yamamichi, N., Inada, Ki. et al. Expression of Gastric Markers Is Associated with Malignant Potential of Nonampullary Duodenal Adenocarcinoma. Dig Dis Sci 63, 2617–2625 (2018). https://doi.org/10.1007/s10620-018-5179-0

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  • DOI: https://doi.org/10.1007/s10620-018-5179-0

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