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Efficacy and Safety of Endoscopic Balloon Dilation for Upper Gastrointestinal Strictures of Crohn’s Disease

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Abstract

Background

Few articles focused on endoscopic balloon dilation (EBD) in the management of Crohn’s strictures in the upper gastrointestinal (GI) tract.

Aims

The purpose of this study was to evaluate the long-term efficacy and safety of EBD for Crohn’s strictures in the upper GI tract and to determine early predictors of response and surgical intervention.

Methods

All eligible patients who underwent EBD for Crohn’s strictures in the upper GI tract were retrospectively reviewed. The long-term success was defined as the recovery of normal diets without surgical intervention over the follow-up period. In order to seek early predictors, patients who achieved long-term success were compared with those who didn’t.

Results

A total of 67 dilations of upper GI strictures were performed between June 2011 and March 2015 on 24 patients (mean age 25.6 ± 6.7, 20 male) with Crohn’s disease. Technical success was achieved in 62 of 67 dilations (92.5 %) with a complication rate of 3 %. After the median follow-up period of 23.0 months (range 6.2–51.2 months), nine patients underwent surgical intervention, nine patients were still depending on tube feeding; in the meantime, only six (25 %) patients achieved long-term success. Additionally, patients who remained 1 month intervention-free (55.6 vs. 5.9 %, P = 0.015) were more likely to achieve long-term success.

Conclusions

EBD was a safe procedure, but not a potent therapy for Crohn’s upper GI strictures. Meanwhile, 1-month response could serve as an early predictor of the long-term response.

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Authors and Affiliations

  1. Department of General Surgery, Jinling Hospital, School of Medicine, Nanjing University, No. 305 East Zhongshan Road, Nanjing, 210002, People’s Republic of China

    Feilong Guo, Yuhua Huang, Weiming Zhu, Zhiming Wang, Lei Cao, Zhen Guo, Yi Li, Jianfeng Gong & Jieshou Li

  2. National Clinical Research Center of Kidney Disease, Jinling Hospital, School of Medicine, Nanjing University, No. 305 East Zhongshan Road, Nanjing, 210002, People’s Republic of China

    Aoxue Chen

Authors
  1. Feilong Guo
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  2. Yuhua Huang
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  3. Weiming Zhu
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  4. Zhiming Wang
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Correspondence to Weiming Zhu.

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Guo, F., Huang, Y., Zhu, W. et al. Efficacy and Safety of Endoscopic Balloon Dilation for Upper Gastrointestinal Strictures of Crohn’s Disease. Dig Dis Sci 61, 2977–2985 (2016). https://doi.org/10.1007/s10620-016-4242-y

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  • DOI: https://doi.org/10.1007/s10620-016-4242-y

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