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Temperature Can Influence Gastric Accommodation and Sensitivity in Functional Dyspepsia with Epigastric Pain Syndrome

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Abstract

Background

Functional dyspepsia-epigastric pain syndrome (FD-EPS) is characterized pathophysiologically by visceral hypersensitivity, but the effect of the temperature stimulation on gastric function has been seldom studied.

Aim

The purpose of this study was to investigate the effects of liquid nutrients at different temperatures on the gastric accommodation, sensitivity, and gastric-wall compliance of healthy subjects (HS) and FD-EPS patients.

Methods

Ten FD-EPS patients (Roma III criteria) and ten HS were recruited into the study. Intragastric pressure (IGP) and gastric perfusion were measured and compared following the administration of liquid nutrients at 37 °C on day 1 and at 8 °C on day 2.

Results

Seven patients developed abdominal discomfort or abdominal pain after being given cold liquid nutrient. The administration of liquid nutrient at 8 °C resulted in an increase of IGP in HS (P = 0.044), a significant decrease in gastric perfusion (P < 0.0001), a marked increase in IGP (P = 0.015), and a dramatic reduction in gastric wall compliance (P = 0.012) in patients compared to the effects of liquid nutrient at 37 °C. In addition, IGP in patients was lower than that in HS at 37 °C liquid nutrient (P = 0.036), and the gastric perfusion volume in patients at maximal satiety was also significantly reduced at 8 °C liquid nutrient compared with HS (P = 0.017).

Conclusions

Cold stimulation can increase the IGP in HS and FD-EPS patients, elevate the visceral sensitivity and reduce the gastric volume of FD-EPS patients. FD-EPS patients who are sensitive to cold may develop epigastric discomfort or pain.

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Acknowledgments

This study was supported by Project of the National Key Technologies R & D Program in the 11th Five Year Plan period (2007BAI04B01), National High-tech R & D Program (“863” Program, 2010AA023007).

Conflict of interest

The authors attest that they have no commercial associations (e.g. equity ownership or interest, consultancy, patient and licensing agreement, or institutional and corporate associations) that might be a conflict of interest in relation to the submitted manuscript.

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Authors and Affiliations

  1. Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, 100730, China

    Rui-Feng Wang, Zhi-Feng Wang, Mei-Yun Ke, Xiu-Cai Fang, Xiao-Hong Sun, Li-Ming Zhu & Jing Zhang

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  1. Rui-Feng Wang
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  2. Zhi-Feng Wang
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Correspondence to Mei-Yun Ke.

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Wang, RF., Wang, ZF., Ke, MY. et al. Temperature Can Influence Gastric Accommodation and Sensitivity in Functional Dyspepsia with Epigastric Pain Syndrome. Dig Dis Sci 58, 2550–2555 (2013). https://doi.org/10.1007/s10620-012-2363-5

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  • DOI: https://doi.org/10.1007/s10620-012-2363-5

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