Skip to main content
SpringerLink
Log in

Endoscopic Patterns and Histopathological Features after Eradication Therapy in Helicobacter pylori-Associated Nodular Gastritis

  • Original Paper
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

The endoscopic finding of nodular gastritis (NG) is highly associated with presence of Helicobacter pylori infection. How the endoscopic patterns and histopathology of NG change after eradication of H. pylori is unclear. Twenty-one adults (3 men and 18 women) with H. pylori-associated NG found on endoscopy were enrolled for this study. The histological findings included gastritis activity, bacterial colonization, and lymphoid follicles. Repeat endoscopy for the endoscopic as well as histopathological features of gastric biopsy specimens was performed 2 months later after eradication treatment. H. pylori was successfully eradicated in 19 patients. Endoscopic NG disappeared in 12, improved in 5, and was unchanged in 4. After treatment, there was significant improvement in scores for gastritis activity [P < 0.001, 95% confidence interval (CI) 1.31–1.91], bacterial colonization (P < 0.001, 95% CI 0.71–1.14) and follicular gastritis (P = 0.047, 95% CI 0.04–0.52), primarily among patients whose endoscopic pattern resolved completely. The disappearance of nodularity on endoscopy was accompanied by a decrease in follicular gastritis score.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Bahu Mda G, da Silveira TR, Maguilnick I, Ulbrich-Kulczynski J (2003) Endoscopic nodular gastritis: an endoscopic indicator of high-grade bacterial colonization and severe gastritis in children with Helicobacter pylori. J Pediatr Gastroenterol Nutr 36:217–222

    Article  PubMed  Google Scholar 

  2. Chen MJ, Wang TE, Chang WH, Liao TC, Lin CC, Shih SC (2007) Nodular gastritis: an endoscopic indicator of Helicobacter pylori infection. Dig Dis Sci 52:2662–2666

    Article  PubMed  Google Scholar 

  3. Luzza F, Pensabene L, Imeneo M, Mancuso M, Contaldo A, Giancotti L, La Vecchia AM, Costa MC, Strisciuglio P, Docimo C, Pallone F, Guandalini S (2001) Antral nodularity identifies children infected with Helicobacter pylori with higher grades of gastric inflammation. Gastrointest Endosc 53:60–64

    Article  PubMed  CAS  Google Scholar 

  4. Zaitoun AM (1995) The prevalence of lymphoid follicles in Helicobacter pylori associated gastritis in patients with ulcers and non-ulcer dyspepsia. J Clin Pathol 4:325–329

    Article  Google Scholar 

  5. Chen XY, Liu WZ, Shi Y, Zhang DZ, Zhang DZ, Xiao SD, Tytgat GN (2002) Helicobacter pylori associated gastric diseases and lymphoid tissue hyperplasia in gastric antral mucosa. J Clin Pathol 55:133–137

    PubMed  CAS  Google Scholar 

  6. Dixon MF, Genta RM, Yardley JH, Correa P (1996) Classification and grading of gastritis. The updated sydney system. International workshop on the histopathology of gastritis, Houston 1994. Am J Surg Pathol 20:1161–1181

    Article  PubMed  CAS  Google Scholar 

  7. Ernst P (1999) Review article: the role of inflammation in the pathogenesis of gastric cancer. Aliment Pharmacol Therap 13:13–18

    Article  Google Scholar 

  8. Hatakeyama M, Brzozowski T (2006) Pathogenesis of Helicobacter pylori infection. Helicobacter 11:14–20

    Article  PubMed  CAS  Google Scholar 

  9. Ohara H, Isomoto H, Wen CY, Ejima C, Murata M, Miyazaki M, Takeshima F, Mizuta Y, Murata I, Koji T, Nagura H, Kohno S (2003) Expression of mucosal addressin cell adhesion molecule 1 on vascular endothelium of gastric mucosa in patients with nodular gastritis. World J Gastroenterol 9:2701–2705

    PubMed  CAS  Google Scholar 

  10. Luzza F, Pensabene L, Imeneo M, Mancuso M, Giancotti L, La Vecchia AM, Costa MC, Strisciuglio P, Pallone F (2002) Antral nodularity and positive CagA serology are distinct and relevant markers of severe gastric inflammation in children with Helicobacter pylori infection. Helicobacter 7:46–52

    Article  PubMed  Google Scholar 

  11. Rad R, Dossumbekova A, Neu B, Lang R, Bauer S, Saur D, Gerhard M, Prinz C (2004) Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection. Gut 53:1082–1089

    Article  PubMed  CAS  Google Scholar 

  12. Miyamoto M, Haruma K, Yoshihara M, Sumioka M, Nishisaka T, Tanaka S, Inoue K, Chayama K (2002) Five cases of nodular gastritis and gastric cancer: a possible association between nodular gastritis and gastric cancer. Dig Liver Dis 34:819–820

    Article  PubMed  CAS  Google Scholar 

  13. Ma ZQ, Tanizawa T, Nihei Z, Sugihara K, Nakamura K (2000) Follicular gastritis associated with Helicobacter pylori. J Med Dent Sci 47:39–47

    PubMed  CAS  Google Scholar 

  14. Miyamoto M, Haruma K, Hiyama T, Kamada T, Masuda H, Shimamoto F, Inoue K, Chayama K (2002) High incidence of B-cell monoclonality in follicular gastritis: a possible association between follicular gastritis and MALT lymphoma. Virchows Arch 440:376–380

    Article  PubMed  CAS  Google Scholar 

  15. Miyamoto M, Haruma K, Yoshihara M, Hiyama T, Sumioka M, Nishisaka T, Tanaka S, Chayama K (2003) Nodular gastritis in adults is caused by Helicobacter pylori infection. Dig Dis Sci 48:968–975

    Article  PubMed  Google Scholar 

  16. Genta RM, Hamner HW, Graham DY (1993) Gastric lymphoid follicles in Helicobacter pylori infection: frequency, distribution, and response to triple therapy. Hum Pathol 24:577–583

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgment

The authors would like to thank Dr. Mary Jeanne Buttrey for critical reading and correction of the manuscript.

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Mackay Memorial Hospital and Mackay Medicine, Nursing and Management College, No. 92, Sec. 2, Chung-Shan N. Road, Taipei, 104, Taiwan, Republic of China

    Ming-Jen Chen, Shou-Chuan Shih, Tsang-En Wang, Chih-Jen Chen & Wen-Hsiung Chang

  2. Department of Pathology, Mackay Memorial Hospital, No. 92, Sec. 2, Chung-Shan N. Road, Taipei, 104, Taiwan, Republic of China

    Yu-Jan Chan

Authors
  1. Ming-Jen Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shou-Chuan Shih
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tsang-En Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yu-Jan Chan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Chih-Jen Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Wen-Hsiung Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ming-Jen Chen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, MJ., Shih, SC., Wang, TE. et al. Endoscopic Patterns and Histopathological Features after Eradication Therapy in Helicobacter pylori-Associated Nodular Gastritis. Dig Dis Sci 53, 1893–1897 (2008). https://doi.org/10.1007/s10620-007-0097-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-007-0097-6

Keywords

Search

Navigation