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A New Austalide from Penicillium sp. SO01

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Chemistry of Natural Compounds Aims and scope

Five austalide meroterpenoids, including a new one named 13-deoxyaustalide Q acid methyl ester, were isolated from the ethyl acetate extract of the fungus Penicillium sp. SO01. The structure of the new compound was determined on the basis of IR, UV, HR-ESI-MS NMR spectra and CD data. The cytotoxicities of compound 1 against three human tumor cell lines were also tested, with IC50 values of 27.66 μM (SW-1990 cell line), 28.77 μM (Hep3B cell line), and 39.93 μM (HepG2 cell line).

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References

  1. J. Peng, X. Zhang, W. Wang, T. Zhu, Q. Gu, and D. Li, Mar. Drugs, 14, 131 (2016).

    Article  Google Scholar 

  2. M. P. Sobolevskaya, O. I. Zhuravleva, E. V. Leshchenko, A. M. Zakharenko, V. A. Denisenko, N. N. Kirichuk, R. S. Popov, D. V. Berdyshev, E. A. Pislyagin, M. V. Pivkin, and S. S. Afiyatullov, Phytochem. Lett., 15, 7 (2016).

    Article  CAS  Google Scholar 

  3. O. I. Zhuravleva, M. P. Sobolevskaya, E. V. Leshchenko, N. N. Kirichuk, V. A. Denisenko, P. S. Dmitrenok, S. A. Dyshlovoy, A. M. Zakharenko, N. Y. Kim, and S. Afiyatullov, J. Nat. Prod., 77, 1390 (2014).

    Article  CAS  Google Scholar 

  4. Y. Zhou, A. Debbab, V. Wray, W. Lin, B. Schulz, R. Trepos, C. Pile, C. Hellio, P. Proksch, and A. H. Aly, Tetrahedron Lett., 55, 2789 (2014).

    Article  CAS  Google Scholar 

  5. W. G. Shan, Z. Y. Wu, W. W. Pang, L. F. Ma, Y. M. Ying, and Z. J. Zhan, Chem. Biodiv., 47, 1718 (2016).

    Google Scholar 

  6. Y. Zhou, A. Mandi, A. Debbab, V. Wray, B. Schulz, W. E. G. Muller, W. Lin, P. Proksch, T. Kurtan, and A. H. Aly, Eur. J. Org. Chem., 2011, 6009 (2011).

    Article  CAS  Google Scholar 

  7. R. M. Horak, P. S. Steyn, R. Vleggaar, and C. J. Rabie, J. Chem. Soc., Perkin Trans. 1, 2, 363 (1985).

  8. R. M. Horak, P. S. Steyn, R. Vleggaar, and C. J. Rabie, Cheminform, 2, 345 (1985).

    Google Scholar 

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Authors and Affiliations

  1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy of Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, P. R. China

    Jia Wang, Yining Sang, Siqi Tang & Peng Zhang

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  1. Jia Wang
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  2. Yining Sang
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  3. Siqi Tang
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  4. Peng Zhang
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Correspondence to Peng Zhang.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2020, pp. 580–582.

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Wang, J., Sang, Y., Tang, S. et al. A New Austalide from Penicillium sp. SO01. Chem Nat Compd 56, 670–673 (2020). https://doi.org/10.1007/s10600-020-03117-9

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  • DOI: https://doi.org/10.1007/s10600-020-03117-9

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