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A New Phenolic Glycoside from Viburnum Melanocarpum Fruits and its α-Glucosidase Inhibitory Activity

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Chemistry of Natural Compounds Aims and scope

A new phenolic glycoside 1, together with its enantiomer (2), was isolated from the ethanolic extract of Viburnum melanocarpum P. S. Hsu fruits by repeated column chromatography. Its structure was identified as (7R,8S)-guaiacylglycerol 4-O-β-D-(6-O-vanilloyl)glucopyranoside (1) by spectroscopic data (1H NMR, 13C NMR, HSQC, HMBC, and ORD) and chemical methods. In the intestinal α-glucosidase inhibitory activity test, compound 1 exhibited potent inhibitory activity with IC50 value of 10.04 μM in comparison with the positive control acarbose (IC50 16.37 μM).

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Acknowledgment

This work was supported by the National Natural Science Foundation of China (No. 31201563) and the Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (PPZY2015C212). We are also grateful to Prof. Huyin Huai, College of Bioscience and Biotechnology, Yangzhou University, for identification of the plant.

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Authors and Affiliations

  1. Jiangsu Key Laboratory of Crop Genetics and Physiology/Co-Innovation Center for Modern Production Technology of Grain Crops, Yangzhou University, 225009, Yangzhou, P. R. China

    Zi-Yang Zhao, Jia Chen, Jie Shen, Jian-Hua Shao, Xu-Hua Huang & Chun-Chao Zhao

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  1. Zi-Yang Zhao
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  2. Jia Chen
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  3. Jie Shen
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  4. Jian-Hua Shao
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  5. Xu-Hua Huang
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  6. Chun-Chao Zhao
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Corresponding author

Correspondence to Chun-Chao Zhao.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2020, pp. 216–217.

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Zhao, ZY., Chen, J., Shen, J. et al. A New Phenolic Glycoside from Viburnum Melanocarpum Fruits and its α-Glucosidase Inhibitory Activity. Chem Nat Compd 56, 246–248 (2020). https://doi.org/10.1007/s10600-020-02998-0

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  • DOI: https://doi.org/10.1007/s10600-020-02998-0

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