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Evaluation of myocardial infarction size with three-dimensional speckle tracking echocardiography: a comparison with single photon emission computed tomography

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Abstract

To assess whether global and regional myocardial strains from three-dimensional speckle tracking echocardiography (3D-STE) correlate with myocardial infarction size (MIS) detected by single photon emission computed tomography (SPECT). Fifty-seven patients with a history of ST-segment elevation myocardial infarction (MI) within 3–6 months were enrolled, alongside 24 healthy volunteers. Left ventricular (LV) global area strain, global longitudinal strain (GLS), global radial strain, global circumferential strain, left ventricular ejection fraction (LVEF) and wall motion score index (WMSI) were measured and compared with the corresponding SPECT-detected MISs. Patients were sub-grouped into massive MIS group (MIS ≥ 12 %) and small MIS group (MIS < 12 %). Myocardial strains of all the LV segments were compared with the corresponding MIS. Global myocardial strain parameters, LVEF and WMSI of the patients were significantly different from the control group (all P < 0.05) and correlated well with MISs, most significantly for GLS (r = 0.728, P < 0.01). Significant differences in myocardial strain parameters were found between the massive and small MIS groups (all P < 0.05). Receiver operating characteristic curve analysis indicated that GLS had a highest diagnostic value and when the cutoff was −13.8 %, the area under the curve was 0.84, with the 70.6 % sensitivity and 87.5 % specificity. Significant differences of myocardial strain parameters were observed between segments with and without transmural MIs (P < 0.01). 3D-STE myocardial strain parameters evaluated LV global MIS, 3D GLS had the highest diagnostic value. It also preliminarily gauged the degree of ischemia and necrosis of regional myocardial segments.

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    Authors and Affiliations

    1. Department of Cardiology, First Affiliated Hospital of Chinese PLA General Hospital, Beijing, 100048, China

      Qiushuang Wang, Chunhong Zhang, Dangsheng Huang, Liwei Zhang, Feifei Yang, Xiuzhi An, Shuhua Wang, Jiarui Guo & Dongdong Ji

    2. Department of Nuclear Medicine, First Affiliated Hospital of Chinese PLA General Hospital, Beijing, 100048, China

      Qiaohong Ouyang & Meiqing Zhang

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    1. Qiushuang Wang
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    2. Chunhong Zhang
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    Correspondence to Dangsheng Huang or Liwei Zhang.

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    All procedures performed in studies involving human participants were in accordance with the ethical standards of the Ethics Committee of the First Affiliated Hospital of People’s Liberation Army General Hospital and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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    Qiushuang Wang and Chunhong Zhang have contributed equally to this study.

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    Wang, Q., Zhang, C., Huang, D. et al. Evaluation of myocardial infarction size with three-dimensional speckle tracking echocardiography: a comparison with single photon emission computed tomography. Int J Cardiovasc Imaging 31, 1571–1581 (2015). https://doi.org/10.1007/s10554-015-0745-4

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