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History of diabetes mellitus and the risk of prostate cancer: the Ohsaki Cohort Study

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Abstract

Objective

The association between diabetes mellitus and the risk of prostate cancer has been tested in previous prospective cohort studies in western populations. However, no evidence from cohort studies is available for Asian populations, whose lifestyle is very different from that of westerners.

Methods

The authors examined the relationship between diabetes mellitus and the risk of prostate cancer in the Ohsaki cohort followed from 1995 to 2003, in which 230 new cases of prostate cancer were identified among 22,458 Japanese men. Baseline information including diabetes mellitus status was collected using a self-administered questionnaire. The Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

Although a history of diabetes mellitus was not associated with the risk of total prostate cancer in this population, after stratification based on the clinical stage of prostate cancer, patients with diabetes mellitus showed a higher risk of advanced prostate cancer with a multivariate adjusted HR = 1.89 (95% CI: 1.02–3.50). The relationship remained robust when we excluded from the analysis cases arising in the first 2 years.

Conclusion

This population-based prospective cohort study indicates that a history of diabetes mellitus is associated with an increased incidence of advanced prostate cancer.

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Abbreviations

BMI:

Body mass index.

CI:

Confidence interval.

HR:

Hazard ratio

NHI:

National health insurance

PSA:

Prostate specific antigen

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Acknowledgments

This study was supported by Grant-in-Aid for Cancer Research and for the Third Term Comprehensive Ten-Year Strategy for Cancer Control (H18-3jigan-ippan-001, h21-3jigan-ippan-003), Ministry of Health, Labour and Welfare, Japan. The funding body has no role in study design; in the data collection, analysis, and interpretation; in the writing of the report; and in the decision to submit the paper for publication. We thank Takeda Science Foundation offering scholarship to Q. L. to conduct this research in Japan.

Conflict of interest

None declared.

Author information

Authors and Affiliations

  1. Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo-Machi, Aoba-Ku, Sendai, Miyagi, 980-8575, Japan

    Qiang Li, Shinichi Kuriyama, Masako Kakizaki, Toshimasa Sone, Masato Nagai, Yumi Sugawara, Kaori Ohmori-Matsuda, Atsushi Hozawa & Ichiro Tsuji

  2. Division of Epidemiology and Biostatistics, Department of Public Health, Xi’an Jiaotong University School of Medicine, 710061, Xi’an, China

    Qiang Li & Hong Yan

  3. Division of Epidemiology, Miyagi Cancer Center Research Institute, Natori, Japan

    Yoshikazu Nishino

Authors
  1. Qiang Li
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  2. Shinichi Kuriyama
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  3. Masako Kakizaki
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  4. Hong Yan
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  5. Toshimasa Sone
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  6. Masato Nagai
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  8. Kaori Ohmori-Matsuda
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  9. Atsushi Hozawa
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  10. Yoshikazu Nishino
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  11. Ichiro Tsuji
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Corresponding author

Correspondence to Qiang Li.

Additional information

Novelty: The relationship between diabetes mellitus and the risk of prostate cancer has been first tested in Asian population and stratified by stage.

Impact: A significant positive association between history of diabetes mellitus and the risk of advanced prostate cancer was found.

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Li, Q., Kuriyama, S., Kakizaki, M. et al. History of diabetes mellitus and the risk of prostate cancer: the Ohsaki Cohort Study. Cancer Causes Control 21, 1025–1032 (2010). https://doi.org/10.1007/s10552-010-9530-9

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  • DOI: https://doi.org/10.1007/s10552-010-9530-9

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