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Methionine synthase A2756G polymorphism and breast cancer risk: a meta-analysis involving 18,953 subjects

  • Epidemiology
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Abstract

The A2756G polymorphism in the methionine synthase (MTR) gene has been implicated in breast cancer risk. However, the published findings are inconsistent. We therefore performed a meta-analysis to investigate this relationship. Eleven published case–control studies, including 8,438 breast cancer cases and 10,515 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. Overall, no significant associations between the MTR A2756G polymorphism and breast cancer risk were found for GG versus AA (OR = 0.98, 95% CI: 0.84–1.15), AG versus AA (OR = 0.95, 95% CI: 0.89–1.01), GG/AG versus AA (OR = 0.95, 95% CI = 0.89–1.01), and GG versus AG/AA (OR = 1.00, 95% CI: 0.86–1.17). However, in the stratified analysis, significantly decreased breast cancer risks were found among Europeans (AG versus AA, OR = 0.90, 95% CI = 0.83–0.98; GG/AG versus AA, OR = 0.90, 95% CI = 0.82–0.97) and studies with population-based controls (AG versus AA, OR = 0.93, 95% CI = 0.86–1.00; GG/AG versus AA, OR = 0.93, 95% CI = 0.86–1.00). When stratifying by the menopausal status, no significant result was observed in all genetic models. Taken together, the results suggest that the MTR A2756G polymorphism may contribute to susceptibility to breast cancer among Europeans.

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The authors are fully responsible for all content and editorial decisions and did not receive financial support or other form of compensation related to the development of the manuscript.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China

    Meiping Lu

  2. Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, People’s Republic of China

    Feng Wang

  3. Department of Oncology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People’s Republic of China

    Jinrong Qiu

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  1. Meiping Lu
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Correspondence to Jinrong Qiu.

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Meiping Lu and Feng Wang have contributed equally to this work.

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Lu, M., Wang, F. & Qiu, J. Methionine synthase A2756G polymorphism and breast cancer risk: a meta-analysis involving 18,953 subjects. Breast Cancer Res Treat 123, 213–217 (2010). https://doi.org/10.1007/s10549-010-0755-9

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  • DOI: https://doi.org/10.1007/s10549-010-0755-9

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