Abstract
Purpose
To describe the clinical features and surgical outcomes of macular dragging or tractional retinal detachment that occurred as a result of fibrovascular tissue (FT) progression toward the posterior retina in eyes with familial exudative vitreoretinopathy (FEVR).
Methods
The medical records of 4 patients (2 girls, 2 boys) with FEVR were reviewed retrospectively.
Results
All 4 patients had retinal dragging or radial retinal folds with FT in the peripheral retina in at least 1 eye at the initial visit. During the follow-up period, all the patients had FT that progressed toward the posterior pole and developed from the peripheral FT, resulting in macular dragging or posterior tractional retinal detachment. Vitrectomy with or without scleral buckling and laser photocoagulation were performed in all 4 cases, with removal of the FT in the posterior pole and segmentation of the FT between the posterior and peripheral FT. The traction resolved postoperatively and the retina extended in all 4 cases.
Conclusions
In 4 cases with FEVR, the FT developed from the peripheral FT, progressed toward the posterior retina, and generated traction. Vitrectomy with focal removal and segmentation of the FT in the posterior pole might be a good surgical option in such eyes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Criswick VG, Schepens CL. Familial exudative vitreoretinopathy. Am J Ophthalmol. 1969;68:578–94.
Pendergast SD, Trese MT. Familial exudative vitreoretinopathy: results of surgical management. Ophthalmology. 1998;105:1015–23.
Nishimura M, Yamana T, Sugino M, Kohno T, Yamana Y, Minei M, et al. Falciform retinal fold as sign of familial exudative vitreoretinopathy. Jpn J Ophthalmol. 1983;27:40–53.
Ranchod TM, Ho LY, Drenser KA, Capone A Jr, Trese MT. Clinical presentation of familial exudative vitreoretinopathy. Ophthalmology. 2011;118:2070–5.
Yamane T, Yokoi T, Nakayama Y, Nishina S, Azuma N. Surgical outcomes of progressive tractional retinal detachment associated with familial exudative vitreoretinopathy. Am J Ophthalmol. 2014;158:1049–55.
Kashani AH, Brown KT, Chang E, Drenser KA, Capone A, Trese MT. Diversity of retinal vascular anomalies in patients with familial exudative vitreoretinopathy. Ophthalmology. 2014;121:2220–7.
Yonekawa Y, Thomas BJ, Drenser KA, Trese MT, Capone A Jr. Familial exudative vitreoretinopathy: spectral-domain optical coherence tomography of the vitreoretinal interface, retina, and choroid. Ophthalmology. 2015;122:2270–7.
Shimouchi A, Takahashi A, Nagaoka T, Ishibazawa A, Yoshida A. Vitreomacular interface in patients with familial exudative vitreoretinopathy. Int Ophthalmol. 2013;33:711–5.
Gotzaridis EV, Lit ES, D’Amico DJ. Progress in vitreoretinal surgery for proliferative diabetic retinopathy. Semin Ophthalmol. 2001;16:31–40.
Kita T, Hata Y, Arita R, Kawahara S, Miura M, Nakao S, et al. Role of TGF-beta in proliferative vitreoretinal diseases and ROCK as a therapeutic target. Proc Natl Acad Sci USA. 2008;105:17504–9.
Durham JT, Dulmovits BM, Cronk SM, Sheets AR, Herman IM. Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy? Invest Ophthalmol Vis Sci. 2015;56:3441–59.
Chow DR, Ferrone PJ, Trese MT. Refractive changes associated with scleral buckling and division in retinopathy of prematurity. Arch Ophthalmol. 1998;116:1446–8.
He S, Chen Y, Khankan R, Barron E, Burton R, Zhu D, et al. Connective tissue growth factor as a mediator of intraocular fibrosis. Invest Ophthalmol Vis Sci. 2008;49:4078–88.
Kubota T, Kurihara K, Ishibashi T, Inomata H. Proliferative vitreoretinopathy in Coats’ disease: clinicohistopathological case report. Ophthalmologica. 1995;209:44–6.
Suzuki T, Joko T, Akao N, Ohashi Y. Following the migration of a Toxocara larva in the retina by optical coherence tomography and fluorescein angiography. Jpn J Ophthalmol. 2005;49:159–61.
Gandorfer A, Putz E, Welge-Lussen U, Gruterich M, Ulbig M, Kampik A. Ultrastructure of the vitreoretinal interface following plasmin assisted vitrectomy. Br J Ophthalmol. 2001;85:6–10.
Furino C, Micelli Ferrari T, Boscia F, Cardascia N, Recchimurzo N, Sborgia C. Triamcinolone-assisted pars plana vitrectomy for proliferative vitreoretinopathy. Retina. 2003;23:771–6.
Ikeda T, Fujikado T, Tano Y, Tsujikawa K, Koizumi K, Sawa H, et al. Vitrectomy for rhegmatogenous or tractional retinal detachment with familial exudative vitreoretinopathy. Ophthalmology. 1999;106:1081–5.
Boldrey EE, Egbert P, Gass JD, Friberg T. The histopathology of familial exudative vitreoretinopathy: a report of two cases. Arch Ophthalmol. 1985;103:238–41.
Acknowledgements
We thank the patients for participating in this study. This work was supported by grants from the Ministry of Health, Labour, and Welfare (H24-Nanchi-Ippan-031) and the National Center for Child Health and Development 25-7.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflicts of interest
M. Takahashi, None; T. Yokoi, None; S. Katagiri, None; T. Y. -Uemura, None; S. Nishina, None; N. Azuma, None.
About this article
Cite this article
Takahashi, M., Yokoi, T., Katagiri, S. et al. Surgical treatments for fibrous tissue extending to the posterior retina in eyes with familial exudative vitreoretinopathy. Jpn J Ophthalmol 62, 63–67 (2018). https://doi.org/10.1007/s10384-017-0547-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10384-017-0547-4