Skip to main content

Advertisement

SpringerLink
Log in

Characteristics of age-related macular degeneration in patients with diabetic retinopathy

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

The purpose of this study was to determine the clinical characteristics of age-related macular degeneration (AMD) in patients with diabetic retinopathy (DR).

Methods

Retrospective, consecutive case series. Twenty-six eyes of 25 Japanese patients were studied. All patients were diagnosed as having exudative AMD with DR. Patients with no apparent DR, dry AMD, neovascular maculopathy associated with high myopia, and age <50 years were excluded. The clinical characteristics of AMD in patients with DR, e.g., gender, age, stage of DR, and type of AMD were evaluated.

Results

In the 26 eyes, 2 eyes (7.7%) were classified as mild nonproliferative DR (NPDR), 7 (27.0%) with moderate NPDR, 16 (61.5%) with severe NPDR and 1 eye (3.8%) with PDR. Of the 26 eyes with exudative AMD, 21 eyes (80.8%) were classified as neovascular AMD, 4 (15.4%) as polypoidal choroidal vasculopathy and 1 eye (3.8%) as a retinal angiomatous proliferation. Among the eyes with neovascular AMD, 9 eyes (42.9%) were classified as predominantly classic choroidal neovascularization (CNV).

Conclusions

There is a predominance of men, neovascular AMD and predominantly classic CNV in Japanese AMD patients with DR. The exudative AMD in patients with DR may have different clinical characteristics from those without DR.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. King H, Rewers M. Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. WHO Ad Hoc Diabetes Reporting Group. Diabetes Care. 1993;16:157–77.

    Article  CAS  PubMed  Google Scholar 

  2. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections. Diabetes Care. 1998;21:1414–31.

    Article  CAS  PubMed  Google Scholar 

  3. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047–53.

    Article  PubMed  Google Scholar 

  4. Miyazaki M, Nakamura H, Kubo M, Kiyohara Y, Oshima Y, Ishibashi T, et al. Risk factors for age related maculopathy in a Japanese population: the Hisayama study. Br J Ophthalmol. 2003;87:469–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Oshima Y, Ishibashi T, Murata T, Tahara Y, Kiyohara Y, Kubota T. Prevalence of age related maculopathy in a representative Japanese population: the Hisayama study. Br J Ophthalmol. 2001;85:1153–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Klein R, Klein BE, Tomany SC, Meuer SM, Huang GH. Ten-year incidence and progression of age-related maculopathy: the Beaver Dam eye study. Ophthalmology. 2002;109:1767–79.

    Article  PubMed  Google Scholar 

  7. Klein R, Klein BE, Jensen SC, Meuer SM. The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology. 1997;104:7–21.

    Article  CAS  PubMed  Google Scholar 

  8. Mitchell P, Wang JJ, Foran S, Smith W. Five-year incidence of age-related maculopathy lesions: the Blue Mountains Eye Study. Ophthalmology. 2002;109:1092–7.

    Article  PubMed  Google Scholar 

  9. Vingerling JR, Dielemans I, Hofman A, Grobbee DE, Hijmering M, Kramer CF, et al. The prevalence of age-related maculopathy in the Rotterdam Study. Ophthalmology. 1995;102:205–10.

    Article  CAS  PubMed  Google Scholar 

  10. Yuzawa M, Tamakoshi A, Kawamura T, Ohno Y, Uyama M, Honda T. Report on the nationwide epidemiological survey of exudative age-related macular degeneration in Japan. Int Ophthalmol. 1997;21:1–3.

    Article  CAS  PubMed  Google Scholar 

  11. Kawasaki R, Wang JJ, Ji GJ, Taylor B, Oizumi T, Daimon M, et al. Prevalence and risk factors for age-related macular degeneration in an adult Japanese population: the Funagata study. Ophthalmology. 2008;115:1376–81.

    Article  PubMed  Google Scholar 

  12. Hyman LG, Lilienfeld AM, Ferris FL 3rd, Fine SL. Senile macular degeneration: a case–control study. Am J Epidemiol. 1983;118:213–27.

    Article  CAS  PubMed  Google Scholar 

  13. Blumenkranz MS, Russell SR, Robey MG, Kott-Blumenkranz R, Penneys N. Risk factors in age-related maculopathy complicated by choroidal neovascularization. Ophthalmology. 1986;93:552–8.

    Article  CAS  PubMed  Google Scholar 

  14. Klein R, Klein BE, Moss SE. Diabetes, hyperglycemia, and age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology. 1992;99:1527–34.

    Article  CAS  PubMed  Google Scholar 

  15. Borrone R, Saravia M, Bar D. Age related maculopathy and diabetes. Eur J Ophthalmol. 2008;18:949–54.

    Article  CAS  PubMed  Google Scholar 

  16. Proctor B, Ambati J. Age-related macular degeneration and diabetic retinopathy: is diabetic retinopathy protective against ARMD? ARVO. 2007;2149 (Suppl).

  17. Zylbermann R, Landau D, Rozenman Y, Abrahami S, Pollack A. Exudative age-related macular degeneration in patients with diabetic retinopathy and its relation to retinal laser photocoagulation. Eye. 1997;11:872–5.

    Article  PubMed  Google Scholar 

  18. Wilkinson CP, Ferris FL 3rd, Klein RE, Lee PP, Agardh CD, Davis M, et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology. 2003;110:1677–82.

    Article  CAS  PubMed  Google Scholar 

  19. Takahashi K, Ishibashi T, Ogura Y, Yuzawa M. Classification and diagnostic criteria of age-related macular degeneration. Nippon Ganka Gakkai Zasshi. 2008;112:1076–84. (in Japanese).

    PubMed  Google Scholar 

  20. Yannuzzi LA, Sorenson J, Spaide RF, Lipson B. Idiopathic polypoidal choroidal vasculopathy (IPCV). Retina. 1990;10:1–8.

    Article  CAS  PubMed  Google Scholar 

  21. Yannuzzi LA, Negrão S, Iida T, Carvalho C, Rodriguez-Coleman H, et al. Retinal angiomatous proliferation in age-related macular degeneration. Retina. 2001;21:416–34.

    Article  CAS  PubMed  Google Scholar 

  22. Barbazetto I, Burdan A, Bressler NM, Bressler SB, Haynes L, Kapetanios AD, et al. Photodynamic therapy of subfoveal choroidal neovascularization with verteporfin: fluorescein angiographic guidelines for evaluation and treatment-TAP and VIP report No. 2. Arch Ophthalmol. 2003;121:1253–68.

    Article  CAS  PubMed  Google Scholar 

  23. Treatment of Age-Related Macular Degeneration With Photodynamic Therapy (TAP) Study Group. Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials-TAP report. Arch Ophthalmol. 1999;117:1329–45.

    Article  Google Scholar 

  24. Yannuzzi LA, Wong DW, Sforzolini BS, Goldbaum M, Tang KC, Spaide RF, et al. Polypoidal choroidal vasculopathy and neovascularized age-related macular degeneration. Arch Ophthalmol. 1999;117:1503–10.

    Article  CAS  PubMed  Google Scholar 

  25. Maruko I, Iida T, Saito M, Nagayama D, Saito K. Clinical characteristics of exudative age-related macular degeneration in Japanese patients. Am J Ophthalmol. 2007;144:15–22.

    Article  PubMed  Google Scholar 

  26. Yoshimura N. Polypoidal choroidal vasculopathy. Folia Ophthalmol Jpn. 2004;55:155–72. (in Japanese).

    Google Scholar 

  27. Ahuja RM, Stanga PE, Vingerling JR, Reck AC, Bird AC. Polypoidal choroidal vasculopathy in exudative and haemorrhagic pigment epithelial detachments. Br J Ophthalmol. 2000;84:479–84.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Ladas ID, Rouvas AA, Moschos MM, Synodinos EE, Karagiannis DA, Koutsandrea CN. Polypoidal choroidal vasculopathy and exudative age-related macular degeneration in Greek population. Eye. 2004;18:455–9.

    Article  CAS  PubMed  Google Scholar 

  29. Sho K, Takahashi K, Yamada H, Wada M, Nagai Y, Otsuji T, et al. Polypoidal choroidal vasculopathy: incidence, demographic features, and clinical characteristics. Arch Ophthalmol. 2003;121:1392–6.

    Article  PubMed  Google Scholar 

  30. Varma R, Macias GL, Torres M, Klein R, Pena FY, Azen SP. Biologic risk factors associated with diabetic retinopathy: the Los Angeles Latino Eye Study. Ophthalmology. 2007;114:1332–40.

    Article  PubMed  Google Scholar 

  31. Xie XW, Xu L, Wang YX, Jonas JB. Prevalence and associated factors of diabetic retinopathy. The Beijing Eye Study 2006. Graefes Arch Clin Exp Ophthalmol. 2008;246:1519–6.

    Article  PubMed  Google Scholar 

  32. Kawasaki R, Wang JJ, Rochtchina E, Taylor B, Wong TY, Tominaga M, et al. Cardiovascular risk factors and retinal microvascular signs in an adult Japanese population: the Funagata Study. Ophthalmology. 2006;113:1378–84.

    Article  PubMed  Google Scholar 

  33. Tahara Y, Takada Y, Fujiawa K, Ishibashi T, Inomata H, Kiyohara Y, et al. Prevalence of diabetic retinopathy in one community: the Hisayama study. Rinsho Ganka. 2000;54:573–5. (in Japanese).

    Google Scholar 

  34. Yannuzzi LA, Ciardella A, Spaide RF, Rabb M, Freund KB, Orlock DA. The expanding clinical spectrum of idiopathic polypoidal choroidal vasculopathy. Arch Ophthalmol. 1997;115:478–85.

    Article  CAS  PubMed  Google Scholar 

  35. Uyama M, Matsubara T, Fukushima I, Matsunaga H, Iwashita K, Nagai Y, et al. Idiopathic polypoidal choroidal vasculopathy in Japanese patients. Arch Ophthalmol. 1999;117:1035–42.

    Article  CAS  PubMed  Google Scholar 

  36. Zawinka C, Ergun E, Stur M. Prevalence of patients presenting with neovascular age-related macular degeneration in an urban population. Retina. 2005;25:324–31.

    Article  PubMed  Google Scholar 

  37. Cohen SY, Creuzot-Garcher C, Darmon J, Desmettre T, Korobelnik JF, Levrat F, et al. Types of choroidal neovascularisation in newly diagnosed exudative age-related macular degeneration. Br J Ophthalmol. 2007;91:1173–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Hidayat AA, Fine BS. Diabetic choroidopathy. Light and electron microscopic observations of seven cases. Ophthalmology. 1985;92:512–22.

    Article  CAS  PubMed  Google Scholar 

  39. Vinores SA, Campochiaro PA, May EE, Blaydes SH. Progressive ultrastructural damage and thickening of the basement membrane of the retinal pigment epithelium in spontaneously diabetic BB rats. Exp Eye Res. 1988;46:545–58.

    Article  CAS  PubMed  Google Scholar 

  40. Fukushima I, McLeod DS, Lutty GA. Intrachoroidal microvascular abnormality: a previously unrecognized form of choroidal neovascularization. Am J Ophthalmol. 1997;124:473–87.

    Article  CAS  PubMed  Google Scholar 

  41. Cao J, McLeod S, Merges CA, Lutty GA. Choriocapillaris degeneration and related pathologic changes in human diabetic eyes. Arch Ophthalmol. 1998;116:589–97.

    Article  CAS  PubMed  Google Scholar 

  42. Bhutto IA, McLeod DS, Hasegawa T, Kim SY, Merges C, Tong P, et al. Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration. Exp Eye Res. 2006;82:99–110.

    Article  CAS  PubMed  Google Scholar 

  43. Nagaoka T, Kitaya N, Sugawara R, Yokota H, Mori F, Hikichi T, et al. Alteration of choroidal circulation in the foveal region in patients with type 2 diabetes. Br J Ophthalmol. 2004;88:1060–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Miyajima H, Takeda M, Imaizumi H, Okushiba U, Furusho F, Miyabe Y, et al. Clinical features of diabetic retinopathy with choroidal neovascularization. Folia Ophthalmol Jpn. 2001;52:498–504. (in Japanese).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Kansai Medical University, Takii Hospital, Osaka, Japan

    Tadanobu Yoshikawa, Mitsumasa Wada & Tsuyoshi Otsuji

  2. Department of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan

    Nahoko Ogata

  3. Department of Ophthalmology, Kansai Medical University, Hirakata Hospital, Osaka, Japan

    Kanji Takahashi

Authors
  1. Tadanobu Yoshikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nahoko Ogata
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mitsumasa Wada
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tsuyoshi Otsuji
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kanji Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nahoko Ogata.

About this article

Cite this article

Yoshikawa, T., Ogata, N., Wada, M. et al. Characteristics of age-related macular degeneration in patients with diabetic retinopathy. Jpn J Ophthalmol 55, 235–240 (2011). https://doi.org/10.1007/s10384-011-0010-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10384-011-0010-x

Keywords

Search

Navigation