Zusammenfassung
Die Endometriose zählt zu den häufigsten gutartigen Erkrankungen der geschlechtsreifen Frau. Trotz des charakteristischen Symptoms der Dysmenorrhö – häufig in Kombination mit Begleitsymptomen wie chronischen Unterbauchschmerzen, Dyschezie, Dysurie und Dyspareunie – dauert es immer noch zu lange, bis die Diagnose gestellt wird. Einfache Methoden der rektovaginalen Untersuchung sind hinweisend. Die Laparoskopie sollte zur Diagnosesicherung frühzeitig angestrebt werden. Eine postoperative Rezidivprophylaxe kann – bei fehlendem Kinderwunsch – sinnvoll sein. In der Rezidivsituation gilt es, individuell und im Konsens mit der Patientin das optimale Behandlungskonzept zu finden. Neben Rezidivoperationen kommen medikamentöse Maßnahmen zum Einsatz: neben Schmerzmedikamenten Gestagene, orale Kontrazeptiva im Langzyklus sowie Gonadotropin-releasing-Hormon(GnRH)-Analoga.
Abstract
Endometriosis is one of the most common benign diseases of the mature woman. In spite of characteristic symptoms like dysmenorrhea—often in combination with accompanying symptoms such as chronic pelvic pain, dyschezia, dysuria and dyspareunia—it still takes too long for the correct diagnosis to be made. Simple methods like rectovaginal exam are indicative. Laparoscopy to confirm the diagnosis should be sought at an early stage. Postoperative recurrence prevention can—if there is no desire for children—make sense. In recurrent endometriosis, therapy must be individually made in consensus with the patient to find the optimal treatment plan. Besides recurrence operations, pharmacological treatment is often used. In addition to pain medications, progestins, oral contraceptives in long-cycle and gonadotropin-releasing hormone (GnRH) analogues are used.
Literatur
Knapp VJ (1999) How old is endometriosis? Late 17th- and 18th-century European descriptions of the disease. Fertil Steril 72:10–14
Kiple K (1993) The Cambridge world history of human disease. Cambridge University Press, Cambridge
McGrew R (1985) Encyclopedia of medical history. McGraw-Hill, New York
Rousset-Jablonski C et al (2011) Catamenial pneumothorax and endometriosis-related pneumothorax: clinical features and risk factors. Hum Reprod 26:2322–2329
Mahmood TA, Templeton A (1991) Prevalence and genesis of endometriosis. Hum Reprod 6:544–549
Moen MH, Schei B (1997) Epidemiology of endometriosis in a Norwegian county. Acta Obstet Gynecol Scand 76:559–562
Vigano P et al (2004) Endometriosis: epidemiology and aetiological factors. Best Pract Res Clin Obstet Gynaecol 18:177–200
Renner SP et al (2006) Endometriose. Geburts Frauenheilk 66:R61–R88
Meyer R (1919) Über den Stand der Frage der Adenomyositis, Adenomyome im Allgemeinen und insbesondere über Adenomyositis seroepithelialis und Adenomyometritis sarcomatosa. Zentralbl Gynakol 43:745–750
Sampson JA (1927) Metastatic or embolic endometriosis, due to the menstrual dissemination of endometrial tissue into the venous circulation. Am J Pathol 3:93–110.43
D’Hooghe TM (1997) Clinical relevance of the baboon as a model for the study of endometriosis. Fertil Steril 68:613–625
Dehoux JP et al (2011) Is the baboon model appropriate for endometriosis studies? Fertil Steril 96:728–733.e3
Burghaus SKP, Fasching PA, Engel A et al (2011) Risk factors for endometriosis in a German case-control study. Geburtshilfe Frauenheilkunde 71:1073–1079
Leslie C et al (2013) Is the detection of endometrial nerve fibers useful in the diagnosis of endometriosis? Int J Gynecol Pathol 32:149–155
Aghaey Meibody F et al (2011) Diagnosis of endometrial nerve fibers in women with endometriosis. Arch Gynecol Obstet 284:1157–1162
Xu L, Pfaltz CR, Arnold W (1993) Human leukocyte antigens in patients with inner ear diseases of unknown etiology. ORL J Otorhinolaryngol Relat Spec 55:125–134
Xu H et al (2013) Vascular endothelial growth factor C is increased in endometrium and promotes endothelial functions, vascular permeability and angiogenesis and growth of endometriosis. Angiogenesis (im Druck)
Al-Jefout M et al (2009) Diagnosis of endometriosis by detection of nerve fibres in an endometrial biopsy: a double blind study. Hum Reprod 24:3019–3024
Cahill DJ (2002) What is the optimal medical management of infertility and minor endometriosis? Analysis and future prospects. Hum Reprod 17:1135–1140
Hassa H et al (2009) Cytokine and immune cell levels in peritoneal fluid and peripheral blood of women with early- and late-staged endometriosis. Arch Gynecol Obstet 279:891–895
Sokolov DI et al (2005) Study of cytokine profile and angiogenic potential of peritoneal fluid in patients with external genital endometriosis. Bull Exp Biol Med 140:541–544
Khorram O et al (1993) Peritoneal fluid concentrations of the cytokine RANTES correlate with the severity of endometriosis. Am J Obstet Gynecol 169:1545–1549
Leyendecker G et al (2004) Uterine peristaltic activity and the development of endometriosis. Ann N Y Acad Sci 1034:338–355
Leyendecker G et al (2002) Endometriosis results from the dislocation of basal endometrium. Hum Reprod 17:2725–2736
Kunz G et al (2000) Structural abnormalities of the uterine wall in women with endometriosis and infertility visualized by vaginal sonography and magnetic resonance imaging. Hum Reprod 15:76–82
Leyendecker G et al (1998) Endometriosis: a dysfunction and disease of the archimetra. Hum Reprod Update 4:752–762
Leyendecker G et al (1996) Uterine hyperperistalsis and dysperistalsis as dysfunctions of the mechanism of rapid sperm transport in patients with endometriosis and infertility. Hum Reprod 11:1542–1551
Ulrich U et al (2010) Interdisziplinäre S1-Leitlinie: Diagnostik und Therapie der Endometriose. AWMF-Leitlinie Nr. 015/045
Kennedy S et al (2005) ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod 20:2698–2704
Alborzi S et al (2004) A prospective, randomized study comparing laparoscopic ovarian cystectomy versus fenestration and coagulation in patients with endometriomas. Fertil Steril 82:1633–1637
Alhamdan D et al (2010) Mirena intra-uterine system: does it improve long term symptoms in women with chronic pelvic pain and/or endometriosis after laparoscopy? A multicentre randomized controlled trial. Rev Recent Clin Trials 5:143–146
Chapron C et al (2011) Oral contraceptives and endometriosis: the past use of oral contraceptives for treating severe primary dysmenorrhea is associated with endometriosis, especially deep infiltrating endometriosis. Hum Reprod 26:2028–2035
Interessenkonflikt
Der korrespondierende Autor gibt für sich und seine Koautoren an, dass kein Interessenkonflikt besteht.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Renner, S., Burghaus, S., Hackl, J. et al. Endometriose. Gynäkologische Endokrinologie 11, 115–128 (2013). https://doi.org/10.1007/s10304-013-0556-4
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10304-013-0556-4
Schlüsselwörter
- Dysmenorrhö
- Chronische Unterbauchschmerzen
- Laparoskopie
- Tief infiltrierende Endometriose
- Gonadotropin-releasing-Hormon