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The relationship between renal volume and renal function in autosomal dominant polycystic kidney disease

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Abstract

Background

In patients with autosomal dominant polycystic kidney disease (ADPKD), renal cysts grow exponentially. Since remaining renal parenchyma has a capacity to compensate for the loss of glomerular filtration, the glomerular filtration rate (GFR) may be sustained until the disease progresses. The purpose of this study was to determine if renal volumetric indices and clinical parameters are associated with renal function in Japanese patients with ADPKD.

Methods

In 73 ADPKD patients (28 men, 45 women), the associations of mean systolic blood pressure, mean diastolic blood pressure, estimated GFR (eGFR), the amount of proteinuria and albuminuria, body mass index (BMI), brachial-ankle pulse wave velocity (baPWV), ankle-brachial index, and total kidney volume (TKV) were retrospectively analyzed.

Results

Multivariate linear regression analysis showed that eGFR was significantly and independently inversely correlated with patients’ age and BMI. The median change in eGFR per year (ΔeGFR/y) was −2.8 ml/min/1.73 m2/year. Multiple linear regression analysis showed that ΔeGFR/y was significantly and independently inversely correlated with the change in TKV per year (ΔTKV/y). Multiple linear regression analysis showed that ΔTKV/y was significantly related to initial TKV and the change in albuminuria per year.

Conclusions

This study demonstrated a significant relationship between the change in renal function and the change in renal volume in Japanese ADPKD patients without renal insufficiency. It is possible that the volume measurements can be used as useful markers for disease progression in Japanese ADPKD patients.

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Acknowledgments

This work was supported in part by a grant for the Progressive Renal Diseases Research Project from the Ministry of Health, Labour and Welfare of Japan.

Conflict of interest

The authors have declared that no conflict of interest exists.

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Authors and Affiliations

  1. Department of Urology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan

    Shino Tokiwa, Satoru Muto, Toshiyuki China & Shigeo Horie

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  1. Shino Tokiwa
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  2. Satoru Muto
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  3. Toshiyuki China
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  4. Shigeo Horie
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Corresponding author

Correspondence to Shigeo Horie.

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Tokiwa, S., Muto, S., China, T. et al. The relationship between renal volume and renal function in autosomal dominant polycystic kidney disease. Clin Exp Nephrol 15, 539–545 (2011). https://doi.org/10.1007/s10157-011-0428-y

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  • DOI: https://doi.org/10.1007/s10157-011-0428-y

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