Abstract
In Bangladesh there are several published papers on superficial mycoses. Deep mycoses are also recognized as an important emerging problem. Here, we estimate the annual incidence and prevalence of serious fungal infections in Bangladesh. Demographic data were obtained from world population reports and the data on TB and HIV extracted from the online publications on tuberculosis in Bangladesh and Asia Pacific research statistical data information resources AIDS Data HUB. All the published papers on fungal infections in Bangladesh were identified through extensive search of literature. We estimated the number of affected people from populations at risk and local epidemiological data. Bangladesh has a population of ∼162.6 million, 31% children and only 6% over the age of 60 years. The pulmonary TB caseload reported in 2014 was 119,520, and we estimate a prevalence of 30,178 people with chronic pulmonary aspergillosis, 80% attributable to TB. An anticipated 90,262 and 119,146 patients have allergic bronchopulmonary aspergillosis or severe asthma with fungal sensitization. Only 8,000 people are estimated to be HIV-infected, of whom 2900 are not on ART with a CD4 count <350 μL, Pneumocystis pneumonia and cryptococcal meningitis being rare. Superficial mycoses are very common with Trichophyton rubrum as the predominant etiological agent (80.6%). Numerous cases of mycotic keratitis have been reported from several parts of Bangladesh. Candida bloodstream infection was estimated based on a 5 per 100,000 rate (8100 cases) and invasive aspergillosis based primarily on leukemia and COPD rates, at 5166 cases. Histoplasmosis was documented in 16 cases mostly with disseminated disease and presumed in 21 with HIV infection. This study constitutes the first attempt to estimate the burden of several types of serious fungal infections in Bangladesh.
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References
Rahim R, Saleh AA (2012) Pattern of dermatophytosis in Bangabandhu Sheikh Mujib Medical University. Bangladesh J Med Microbiol 6(2):11–14
Rehman MH, Hadiuzzaman M, Bhuiyan MKJ, Islam N, Ansari NP, Mumu SA, Chowudhary IJ (2011) Prevalence of superficial fungal infections in the rural areas of Bangladesh. Iran J Dermatol 14(3):86–91
Dunlop AA, Wright ED, Howlader SA, Nazrul I, Husain R, McClellan K, Billson FA (1994) Suppurative corneal ulceration in Bangladesh: a study of 142 cases examining the microbiological diagnosis, clinical and epidemiological features of bacterial and fungal keratitis. Aust NZ J Ophthalmol 22(2):105–110
Parvin R, Amin R, Mahbub MS, Hasnain M, Arif KM, Miah MT, Gupta RD, Alam MB, Ahasan HAMN (2010) Deep fungal infection—an emerging problem in Bangladesh. J Med 11(2):170–175. doi:10.3329/jom.v11i2.5466
Mahbub MS, Ahasan HAMN, Miah MT, Alam MB, Gupta RD, Arif KM, Hasnain M (2010) Disseminated histoplasmosis. J Med 11(1):70–73. doi:10.3329/jom.v11i1.4278
Sadat SMA, Rita SN, Kahhar MA (2012) Oral histoplasmosis: report of two cases. J Bangladesh Coll Phys Surg 30(4):229–233
Chowdhary M, Memud T, Sarker ZM, Huda S, Ahmed S, Jahan F, Rafiquddin AKM (2004) Rhino-cerebral mucormycosis—a case report. J Bangladesh Coll Phys Surg 22(3):111–115
Habib R, Islam R, Rahman A, Bhowmik NB, Haque A (2012) Rhino-orbito-cerebral mucormycosis with osteomyelitis in a patient with diabetes mellitus. A case report and literature review. Birdem Med J 2(2):124–127. doi:10.3329/birdem.v2i2.12331
Haq JA, Khan MAM, Afroz N, Haq T (2007) Localized primary renal aspergillosis in a diabetic patient following lithotripsy- a case report. BMC Infect Dis 7:58. doi:10.1186/1471-2334-7-58
Hossain A, Islam QT, Sidiqqui MMR (2009) Pulmonary aspergilloma. J Med 10(2):149–151
Islam S, Das A, Islam N (2010) Cryptococcosis in organ transplantation. Mymensingh Med J 19(1):142–143
Worldometers (2016) Bangladesh population (Live). Available online at: http://www.worldometers.info/world-population/bangladesh-population/. Accessed in May 2016
Zaman K, Hossein H (2007) Tuberculosis in Bangladesh. Available online at: http://www.maptb.org.my/files/iuatld2007/Tuberculosis in Bangladesh.pdf. Accessed in July 2016
HIV AIDS Asia Pacific Research Statistical Data Information resources AIDS Data HUB (2016) Bangladesh Key Facts on HIV Available online at:http://www.aidsdatahub.org/Country-Profiles/Bangladesh/. Accessed in June 2016
Alam DS, Chowdhury MA, Siddiquee AT, Ahmed S, Clemens J (2015) Prevalence and determinants of obstructive pulmonary disease (COPD) in Bangladesh. COPD 12(6):658–667
Chowdhury MA, Kabir ARML, Alam MM (2008) Allergic rhinitis, asthma and atopic diseases: Bangladesh perspective. Bangladesh J Otorhinolaryngol 14(2):66–70
Ali M (2012) Organ transplantation in Bangladesh-challenges and opportunities (Editorial). Ibrahim Med Coll J 6(1):i–ii
Ali M, Gupta S, Zafar SMA, Rashid M, Husain MM, Rabbi H et al (2014) Initiation of liver transplantation in Bangladesh: report on the first two successful Cases. J Health Popul Nutr 32(4):696–700
Huq F, Moazzam MG, Shaharuzzaman (1978) Candida infection in human. Bangladesh Med Res Counc Bull 4(1):28–31
Aktar T, Towhid ST, Islam KMS, Fatema K, Islam S, Majumder P, Datta S (2015) Bacterial skin and soft tissue infections in Dhaka, Bangladesh. IOSR J Pharm & Biolog Sci 10(2):20–26. doi:10.9790/3008-10232026
Yusuf MA, Chowdhury MAK, Sattar ANI, Rahman MM (2007) Evaluation of the effect of contraceptives on the prevalence of Candida species on vaginal candidiasis in Dhaka, Bangladesh. Bangladesh J Med Microbiol 1(2):61–66
Denning DW, Pleuvry A, Cole DC (2011) Global burden of chronic pulmonary aspergillosis as sequel to tuberculosis. Bull WHO 89:864–872
Zaman K, Takeuchi H, Md Y, El Arifeen S, Chowdhury HR, Baqui AH, Wakai S, Iwata T (2007) Asthma in rural Bangladeshi children. Indian J Pediatr 74(6):539–543
Aggarwal R, Denning DW, Chakrabarti A (2014) Estimation of the burden of chronic and allergic pulmonary aspergillosis in India. PLoS One 9:e114745
Hassan M, Khan MH, Ahmed AU, Morshed MM, Chakraborty MR, Ahmed K (2011) Maxillary sinusitis and fungal infection. Mymensingh J Med 20(3):459–462
Chakrabarti A, Rudramurhty SM, Panda N, Das A, Singh A (2015) Epidemiology of chronic fungal rhinosinusitis in rural India. Mycoses 58(3):294–302
Denning DW, Gugnani HC (2015) Burden of serious fungal infections in Trinidad and Tobago. Mycoses 58(Suppl S5):80–84
Matin N, Shahrin L, Pervez MM, Banu S, Ahmed D, Khatun M, Pietroni M (2011) Clinical profile of hospitalized HIV/AIDS-infected patients admitted to a new specialist unit in Dhaka, Bangladesh-A low prevalence country for HIV. J Health Popul Nutr 29(1):14–19
Shahrin L, Leung DT, Matin N, Pervez MM, Bardhan PK, Azim T, Heffelfinger JD, Chisti MJ (2014) Characteristics and predictors of death among hospitalized HIV-infected patients in a low HIV prevalence country: Bangladesh. PLoS One 9(12):e113095. doi:10.1371/journal.pone.0113095
Islam N, Islam M, Muazzam MG (1962) A histoplasmosis survey in East Pakistan. Trans Roy Trop Med Hyg 56:246–249
Islam N, Sobhan MA (1971) Sensitivity to histoplasmin, coccidioidin, blastomycin and tuberculin in East Pakistan. Am J Trop Med Hyg 20(4):621–624
Antinor S (2014) Histoplasma capsulatum: More widespread than previously thought. Am J Trop Med Hyg 90(6):982–983. doi:10.4269/ajtmh.14-0175
Biswas SS, Al-Amin Z, Razib FA, Mahbub S (2013) Acute fungal rhinosinusitis: our experience in immunocompromised host. Mymensingh J Med 22(4):814–819
Williams G, Husun R, Alam S, Howlader A, Islam N, McClellan K (1987) Microbial diagnosis of supportive keratitis in Bangladesh. Br J Ophthalmol 71:315–321. doi:10.1136/bjo.71.4.315
Rahman MR, Johnson GJ, Husain R, Howladar SA, Minassian DC (1998) Randomized trial of 0.2% chlorohexidine gluconate and 2.5% natamycin for fungal keratitis in Bangladesh. Br J Ophthalmol 82:919–925. doi:10.1136/bjo.82.8.919
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Gugnani, H.C., Denning, D.W., Rahim, R. et al. Burden of serious fungal infections in Bangladesh. Eur J Clin Microbiol Infect Dis 36, 993–997 (2017). https://doi.org/10.1007/s10096-017-2921-z
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DOI: https://doi.org/10.1007/s10096-017-2921-z