Abstract
The purpose of this study was to identify seizure outcome and factors potentially predictive for seizure outcome in patients with juvenile absence epilepsy (JAE). In this case–control study all patients with JAE were recruited at the outpatient epilepsy clinic at Shiraz University of Medical Sciences from 2008 till 2012. All patients had to be under the care of the epileptologist for at least 18 months. We divided the patients into two groups: patients who were seizure free in the last 12 months of their follow-up period and those who had any seizures. During the study period, 2750 patients with epilepsy were registered at our epilepsy clinic; 641 patients (23.3 %) had idiopathic generalized epilepsy (IGE). Among patients with IGE, 81 patients (12.6 %) were diagnosed as having JAE and of these, 33 patients (20 women and 13 men) were eligible to enter into the study. Ten patients (30.3 %) were seizure free in the last 12 months of their follow-up and 23 (69.6 %) patients reported at least one seizure of any type. We could not identify any factor to be associated with seizure outcome in these patients. All studies in the literature suffer from small number of patients; so does our study. Besides, they used different methodologies. A large multicenter study is required to explore the variables that predict seizure outcome in patients with juvenile absence epilepsy. This is particularly needed to provide an appropriate counselling for patients and their families and also to formulate better individualized treatment plans for the patients.
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References
Nordi DR (2005) Idiopathic generalized epilepsies recognized by the International League Against Epilepsy. Epilepsia 46(Suppl 9):48–56
Asadi-Pooya AA, Emami M, Sperling MR (2013) A clinical study of syndromes of idiopathic (genetic) generalized epilepsy. J Neurol Sci 324(1–2):113–117
Aiguabella Macau M, Falip Centellas M, de Las Veciana, Heras M et al (2011) Long term prognosis of juvenile absence epilepsy. Neurologia 26(4):193–199
Tovia E, Goldberg-Stern H, Shahar E, Kramer U (2006) Outcome of children with juvenile absence epilepsy. J Child Neurol 21(9):766–768
Marson AG, Al-Kharusi AM, Alwaidh M (2007) The SANAD study of effectiveness of Valproate, Lamotrigine, or Topiramate for generalized and unclassifiable epilepsy: an unblinded randomized controlled trial. Lancet 369:1016–1026
Asadi-Pooya AA, Emami M, Ashjazadeh N, Nikseresht A, Shariat A, Petramfar P et al (2013) Reasons for uncontrolled seizures in adults; the impact of pseudointractability. Seizure 22(4):271–274
Trinka E, Baumgartner S, Unterberger I et al (2004) Long-term prognosis for childhood and juvenile absence epilepsy. J Neurol 251(10):1235–1241
Danhofer P, Brázdil M, Ošlejšková H, Kuba R (2014) Long-term seizure outcome in patients with juvenile absence epilepsy; a retrospective study in a tertiary referral center. Seizure 23(6):443–447
Acknowledgments
We would like to thank Neurosciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran for financially supporting this study.
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Ali A. Asadi-Pooya has received honoraria from Cobel Daru. Mohsen Farazdaghi has no conflict of interest.
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Asadi-Pooya, A.A., Farazdaghi, M. Seizure outcome in patients with juvenile absence epilepsy. Neurol Sci 37, 289–292 (2016). https://doi.org/10.1007/s10072-015-2411-y
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DOI: https://doi.org/10.1007/s10072-015-2411-y