Skip to main content

Advertisement

SpringerLink
Log in

Mantle cell lymphoma with a unique pattern of CD5 expression: a case report with review of the literatures

  • Case Report
  • Published:
Medical Molecular Morphology Aims and scope Submit manuscript

Abstract

Mantle cell lymphoma (MCL) is a unique subtype of B-cell non-Hodgkin’s lymphoma characterized by chromosomal translocation t(11;14)(q13;q32), positive CD5, and nuclear cyclin D1 overexpression with unfavorable prognosis. We report herein a case of MCL in a 73-year-old male diagnosed with diffuse large B-cell lymphoma (ileal tumor) at another hospital, who subsequently relapsed with CD5-negative MCL. At the 1st relapse, he developed neck lymph node swelling, of which biopsy showed proliferation of atypical large pleomorphic cells with CD5-negativity by both immunohistochemistry and flow cytometry. At the 2nd relapse, he again developed an ileal tumor, of which biopsy showed positivity for CD5, CD20, and cyclin D1. In MCL, CD5-negative expression has sometimes been reported as having pleomorphic and blastoid variants. The present case was also histologically the pleomorphic type, but the CD5 expression changed from negative at the onset and the 1st relapse to positive at the 2nd relapse. This is a rare and interesting case because of the different expression of CD5 at all stage. This phenomenon made the diagnosis of MCL difficult.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Lai R, Medeiros LJ (2000) Pathologic diagnosis of mantle cell lymphoma. Clin Lymphoma 1:197–206

    Article  PubMed  CAS  Google Scholar 

  2. Swerdlow SH, Williams ME (2002) From centrocytic to mantle cell lymphoma: a clinicopathologic and molecular review of 3 decades. Hum Pathol 33:7–20

    Article  PubMed  CAS  Google Scholar 

  3. Camacho Fl, Garcia JF, Cigudosa JC, Mollejo M, Algara P, Ruíz-Ballesteros E, Gonzalvo P, Martín P, Pérez-Seoane C, Sánchez-García J, Piris MA (2004) Aberrant Bcl6 protein expression in mantle cell lymphoma. Am J Surg Pathol 23:1051–1056

    Article  Google Scholar 

  4. Morice WG, Hodnefield JM, Kurtin PJ, Hanson CA (2004) An unusual case of leukemic mantle cell lymphoma with a blastoid component showing loss of CD5 and aberrant expression of CD10. Am J Clin Pathol 122:122–127

    Article  PubMed  Google Scholar 

  5. Looi A, Gascoyne RD, Chhanabhai M, Connors JM, Rootman J, White VA (2005) Mantle cell lymphoma in the ocular adnexal region. Ophthalmology 112:114–119

    Article  PubMed  Google Scholar 

  6. van Dongen JJ, Langerak AW, Brüggemann M, Evans PA, Hummel M, Lavender FL, Delabesse E, Davi F, Schuuring E, García-Sanz R, van Krieken JH, Droese J, González D, Bastard C, White HE, Spaargaren M, González M, Parreira A, Smith JL, Morgan GJ, Kneba M, Macintyre EA (2003) Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 concerted action BMH4-CT98-3936. Leukemia 17:2257–2317

    Article  PubMed  Google Scholar 

  7. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri S, Stein H, Thiele J (2008) WHO classification of tumours of haematopoietic and lymphoid tissues, vol 2, 4th edn. (IARC WHO Classification of Tumours). IARC Press, Lyon

  8. Banks PM, Chan J, Cleary ML, Delsol G, De Wolf-Peeters C, Gatter K, Grogan TM, Harris NL, Isaacson PG, Jaffe ES (1992) Mantle cell lymphoma. A proposal for unification of morphologic, immunologic, and molecular data. Am J Surg Pathol 16:637–640

    Article  PubMed  CAS  Google Scholar 

  9. Yin CC, Medeiros LJ, Cromwell CC, Mehta AP, Lin P, Luthra R, Abruzzo LV (2007) Sequence analysis proves clonal identity in five patients with typical and blastoid mantle cell lymphoma. Mod Pathol 20:1–7

    Article  PubMed  CAS  Google Scholar 

  10. Argatoff LH, Connors JM, Klasa RJ, Horsman DE, Gascoyne RD (1997) Mantle cell lymphoma: a clinicopathologic study of 80 cases. Blood 89:2067–2078

    PubMed  CAS  Google Scholar 

  11. Lardelli P, Bookman MA, Sundeen J, Longo DL, Jaffe ES (1990) Lymphocytic lymphoma of intermediate differentiation. Morphologic and immunophenotypic spectrum and clinical correlations. Am J Surg Pathol 14:752–763

    Article  PubMed  CAS  Google Scholar 

  12. Norton AJ, Matthews J, Pappa V, Shamash J, Love S, Rohatiner AZ, Lister TA (1995) Mantle cell lymphoma: natural history defined in a serially biopsied population over a 20-year period. Ann Oncol 6:249–256

    PubMed  CAS  Google Scholar 

  13. Swerdlow SH, Habeshaw JA, Murray LJ, Dhaliwal HS, Lister TA, Stansfeld AG (1983) Centrocytic lymphoma: a distinct clinicopathologic and immunologic entity. A multiparameter study of 18 cases at diagnosis and relapse. Am J Pathol 113:181–197

    PubMed  CAS  PubMed Central  Google Scholar 

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of Hematology, Gifu Prefectural General Medical Center, Gifu, Japan

    Toshiki Yamada

  2. First Department of Internal Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan

    Naoe Goto, Hisashi Tsurumi & Hisataka Moriwaki

  3. Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu, Japan

    Naoe Goto, Yusuke Kito & Tamotsu Takeuchi

  4. Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Katsuyoshi Takata, Yasuharu Sato & Tadashi Yoshino

  5. Department of Pathology, Gifu Prefecture General Medical Center, Gifu, Japan

    Hitoshi Iwata

Authors
  1. Toshiki Yamada
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Naoe Goto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hisashi Tsurumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Katsuyoshi Takata
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yasuharu Sato
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tadashi Yoshino
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hisataka Moriwaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yusuke Kito
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Tamotsu Takeuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Hitoshi Iwata
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hisashi Tsurumi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yamada, T., Goto, N., Tsurumi, H. et al. Mantle cell lymphoma with a unique pattern of CD5 expression: a case report with review of the literatures. Med Mol Morphol 47, 169–175 (2014). https://doi.org/10.1007/s00795-013-0060-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00795-013-0060-x

Keywords

Search

Navigation