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A rare malignancy of the parotid gland in a 13-year-old Taiwanese boy: case report of a mammary analogue secretory carcinoma of the salivary gland with molecular study

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Abstract

Mammary analogue secretory carcinoma (MASC) is a recently described malignancy of the salivary glands characterized by an ETV6-NTRK3 (EN) fusion gene. Morphologically, MASC is sometimes difficult to distinguish from acinic cell carcinoma. Consequently, identifying the chromosomal translocation is essential for diagnosis. We present a case of parotid gland MASC in a 13-year-old boy. To the best of our knowledge, this is the youngest case reported in the literature. Histologic evaluation showed a tumor composed of microcysts, tubular structures, solid nests, or papillary architecture, with secretions within the lumens of the cysts or tubules. Immunohistochemically, tumor cells showed diffuse positive staining of S-100 protein, cytokeratin 19, and vimentin. ETV6 rearrangement was detected by fluorescence in situ hybridization and EN fusion transcripts were verified by reverse transcription (RT-PCR) assay.

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Acknowledgments

We thank Dr. Ying-Tai Jin (Taiwan Adventist Hospital, Taiwan) and Dr. Hsuan-Ying Huang (Kaohsiung Chang Gung Memorial Hospital, Taiwan) for their expert pathological assistance and discussion.

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Authors and Affiliations

  1. Department of Surgical Pathology, Changhua Christian Hospital, 135 Nanxiao Street, Changhua, Taiwan, ROC

    Michael J. Hwang, Pei Ru Wu, Chia-Yu Chen & Chih-Jung Chen

  2. Department of Otorhinolaryngology, Head and Neck Surgery, Changhua Christian Hospital, Changhua, Taiwan

    Chih-Ming Chen

  3. Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan

    Chih-Jung Chen

  4. School of Medicine, Chung Shan Medical University, Taichuang, Taiwan

    Chih-Jung Chen

Authors
  1. Michael J. Hwang
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  2. Pei Ru Wu
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  3. Chih-Ming Chen
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  4. Chia-Yu Chen
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  5. Chih-Jung Chen
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Corresponding author

Correspondence to Chih-Jung Chen.

Additional information

M. J. Hwang and P. R. Wu two have contributed equally.

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Hwang, M.J., Wu, P.R., Chen, CM. et al. A rare malignancy of the parotid gland in a 13-year-old Taiwanese boy: case report of a mammary analogue secretory carcinoma of the salivary gland with molecular study. Med Mol Morphol 47, 57–61 (2014). https://doi.org/10.1007/s00795-013-0051-y

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  • DOI: https://doi.org/10.1007/s00795-013-0051-y

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