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Association between depressive symptoms and reproductive variables in a group of perimenopausal women attending a menopause clinic in México City

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Abstract

The aim of this study was to explore the association between depressive symptoms and some variables related to the reproductive life, such as history of premenstrual dysphoric disorder, antecedent of postpartum depression, previous use of hormonal contraceptives, and current hot flushes, in a group of perimenopausal women attending a menopause clinic. Perimenopausal women, 45 to 55 years old, who had not received hormonal replacement therapy and/or psychotropic medication, were invited to participate in this study. 141 perimenopausal women were included; we obtained their psychiatric and gynecological data, and we evaluated their depressive symptomatology using the CES-D scale. There were a significantly higher number of cases of previous depressive episodes, PMDD and PPD history in depressed patients compared with non-depressed women; current hot flushes prevalence was similar between depressed and non-depressed women. Patients with a PMDD history were more likely to have experienced previous depressive episodes, a PPD history, and high levels of depression. Variables associated with the level of depression were a previous history of PMDD, current hot flushes, and previous depressive episodes. The occurrence of perimenopausal depression is related to a previous history of PMDD, PPD, and depressive episodes; hot flushes only increase the severity of the depressive episode.

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References

  • Arpels JC (1996) The female brain hypoestrogenic continuum from the premenstrual syndrome to menopause: a hypothesis and review of supporting data. J Reprod Med 41:633–639

    CAS  PubMed  Google Scholar 

  • Avis NE, Brambilla D, McKinlay SM et al (1994) A longitudinal analysis of the association between menopause and depression. Results from the Massachusetts Women´s Health Study. Ann Epidemiol 4:214–220

    Article  CAS  PubMed  Google Scholar 

  • Brandon AR, Shivakumar G, Freeman M (2008) Perimenopausal depression: covering mood and vasomotor symptoms. Curr Psychiatry online 7(10). Accessed Dec 25, 2008

  • Bromberger JT, Matthews KA (1996) A longitudinal study of the effects of pessimism, trait anxiety, and life stress on depressive symptoms in middle-aged women. J Pers Soc Psychol 70:591–598

    Article  CAS  PubMed  Google Scholar 

  • Bromberger JT, Matthews KA, Schott LL et al (2007) Depressive symptoms during the menopausal transition: the Study of Women´s Health Across the Nation (SWAN). J Affect Disord 103(1–3):267–72

    Article  PubMed  Google Scholar 

  • Bromberger J, Kravitz H, Matthews K et al (2009) Predictors of first lifetime episodes of major depression in midlife women. Psychol Med 39(1):55–64

    Article  CAS  PubMed  Google Scholar 

  • Callegari C, Buttarelli M, Cromi A et al (2007) Female psychopathologic profile during menopausal transition: a preliminary study. Maturitas 56(4):447–451

    Article  PubMed  Google Scholar 

  • Cohen LS, Soares CN, Vitonis AF et al (2006) Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cycles. Arch Gen Psychiatry 63(4):385–390

    Article  PubMed  Google Scholar 

  • Critchlow DG, Bond AJ, Wingrove J (2001) Mood disorder history and personality assessment in premenstrual dysphoric disorder. J Clin Psychiatry 62(9):688–693

    CAS  PubMed  Google Scholar 

  • Daly R, Danaceau M, Rubinow D et al (2003) Concordant restoration of ovarian function and mood in perimenopausal depression. Am J Psychiatry 160:1842–1846

    Article  PubMed  Google Scholar 

  • Deecher D, Andree TH, Sloan D, Schechter LE (2008) From menarche to menopause: exploring the underlying biology of depression in women experiencing hormonal changes. Psychoneuroendocrinology 33:3–17

    Article  PubMed  Google Scholar 

  • Dooley M, Bell B (2007) Psychosocial aspects of the menopause. In: Springer (ed) Psychological challenges in Obstetrics and Gynecology: The clinical management, p. 332

  • Douma SL, Husband C, O’Donell ME et al (2005) Estrogen-related mood disorders. Reproductive life cycle factors. Adv Nursing Sci 28(4):364–375

    CAS  Google Scholar 

  • Eriksson O, Wall A, Marteinsdottir I et al (2006) Mood changes correlate to changes in brain serotonin precursor trapping in women with premenstrual dysphoria. Psychiatry Res 146:107–116

    Article  CAS  PubMed  Google Scholar 

  • Freeman EW, Sammel MD, Liu L et al (2004a) Hormones and menopausal status as predictors of depression in women in transition to menopause. Arch Gen Psychiatry 61(1):62–70

    Article  CAS  PubMed  Google Scholar 

  • Freeman EW, Sammel MD, Rinaudo PJ et al (2004b) Premenstrual syndrome as a predictor of menopausal symptoms. Obstet Gynecol 103(5 Pt 1):960–966

    CAS  PubMed  Google Scholar 

  • Freeman EW, Sammel MD, Lin H et al (2006) Associations of hormones and menopausal status with depressed mood in women with no history of depression. Arch Gen Psychiatry 63(4):375–382

    Article  CAS  PubMed  Google Scholar 

  • Frey BN, Lord C, Soares CN (2008) Depression during menopausal transition: a review of treatment strategies and pathophysiological correlates. Menopause Int 14:123–128

    Article  PubMed  Google Scholar 

  • Fugate WN, Sullivan ME (2005) Symptoms during the perimenopause: prevalence, severity, trajectory, and significance in women´s lives. Am J Med 118(12B):14S–24S

    Google Scholar 

  • Gregory R, Masand P, Yohai N (2000) Depression across the reproductive life cycle: correlations between events. Primary Care Companion J Clin Psychiatry 2:127–129

    Article  PubMed  Google Scholar 

  • Halbreich U, Tworek H (1993) Altered serotonergic activity in women with dysphoric premenstrual syndromes. Int J Psychiatry Med 23:1–27

    CAS  PubMed  Google Scholar 

  • Harlow BL, Cohen LS, Otto MW (1999) Prevalence and predictors of depressed symptoms in older premenopausal women: the Harvard study of moods and cycles. Arch Gen Psychiatry 56(5):418–424

    Article  CAS  PubMed  Google Scholar 

  • Hsiao MC, Liu CY, Chen KC et al (2002) Characteristics of women seeking treatment for premenstrual syndrome in Taiwan. Acta Psychiatr Scand 106:150–155

    Article  PubMed  Google Scholar 

  • Joffe H, Hall JE, Soares CN et al (2002) Vasomotor symptoms are associated with depression in perimenopausal women seeking primary care. Menopause 9(6):392–398

    Article  PubMed  Google Scholar 

  • Joffe H, Cohen LS, Harlow BL (2003) Impact of oral contraceptive pill use on premenstrual mood: predictors of improvement and deterioration. Am J Obstet Gynecol 189:1523–1528

    Article  CAS  PubMed  Google Scholar 

  • Kaufert PA, Gilbert P, Tate R (1992) The Manitoba project: a re-examination of the link between menopause and depression. Maturitas 14:143–155

    Article  CAS  PubMed  Google Scholar 

  • Kurshan N, Neill Epperson C (2006) Oral contraceptives and mood in women with and without premenstrual dysphoria: a theoretical model. ArchWomens Ment Health 9(1):1–14

    Article  CAS  Google Scholar 

  • Maartens LW, Knottnerus JA, Pop VJ (2002) Menopausal transition and increased depressive symptomatology: a community based prospective study. Maturitas 42(3):195–200

    Article  CAS  PubMed  Google Scholar 

  • Menkes DB, Coates DC, Fawcett JP (1994) Acute tryptophan depletion aggravates premenstrual syndrome. J Affect Disord 32:37–44

    Article  CAS  PubMed  Google Scholar 

  • Moreno FA, McGahuey CA, Freeman MP et al (2006) Sex differences in depressive response during monoamine depletions in remitted depressive subjects. J Clin Psychiatry 67:1618–1623

    Article  CAS  PubMed  Google Scholar 

  • Novaes C, Almeida OP, de Melo NR (1998) Mental health among perimenopausal women attending a menopause clinic: possible association with premenstrual syndrome? Climacteric 1:264–270

    Article  CAS  PubMed  Google Scholar 

  • Oinonen KA, Masmanian D (2002) To what extent do oral contraceptives influence mood and affect? J Affect Disord 70:229–240

    Article  CAS  PubMed  Google Scholar 

  • Oztürk O, Eraslan D, Mete HE et al (2006) The risk factors and symptomatology of perimenopausal depression. Maturitas 55(2):180–186

    Article  PubMed  Google Scholar 

  • Richards M, Dr R, Daly RC et al (2006) Premenstrual symptoms and perimenopausal depression. Am J Psychiatry 163:133–137

    Article  PubMed  Google Scholar 

  • Robertson Blackmore E, Craddock N, Walters J et al (2008) Is the perimenopause a time of increased risk of recurrence in women with a history of bipolar affective postpartum psychosis? A case series. Arch Women Ment Health 11:75–78

    Article  CAS  Google Scholar 

  • Rybaczyk LA, Bashaw M, Pathak DR et al (2005) An overlooked connection: serotonergic mediation of estrogen-related physiology and pathology. BMC Women´s Health 5:12

    Article  PubMed  CAS  Google Scholar 

  • Schmidt PJ, Murphy JH, Haq N et al (2004) Stressful life events, personal loses, and perimenopause-related depression. Arch Womens Ment Health 7(1):19–26

    Article  CAS  PubMed  Google Scholar 

  • Soares CN, Zytek B (2008) Reproductive hormone sensitivity and risk for depression across the female cycle: a continuum of vulnerability? J Psychiatry Neurosci 33(4):331–343

    PubMed  Google Scholar 

  • Soules MR, Sherman Sh, Parrot E et al (2001) Executive summary: stages of reproductive aging workshop (STRAW). Fertil Steril 76(5):874–878

    Article  CAS  PubMed  Google Scholar 

  • Steinberg EM, Rubinow DR, Bartko JJ et al (2008) A cross-sectional evaluation of perimenopausal depression. J Clin Psychiatry 69(6):973–80

    Article  PubMed  Google Scholar 

  • Stewart DE, Boydel KM (1993) Psychologic distress during menopause: associations across the reproductive cycle. Int J Psychiatry Med 23:157–162

    CAS  PubMed  Google Scholar 

  • World Health Oganization (1981) Report of a WHO Scientific group: Research on the menopause. World Health Organization, Geneva 1981. WHO Technical Report Series, No. 866

    Google Scholar 

  • Yonkers KA (1997) The association between premenstrual dysphoric disorder and other mood disorders. J Clin Psychiatry 58(15):19–25

    PubMed  Google Scholar 

  • Young E, Kornstein S, Harvey A et al (2007) Influences of hormone-based contraception on depressive symptoms in perimenopausal women with major depression. Psychoneuroendocrinology 32(7):843–853

    Article  CAS  PubMed  Google Scholar 

Download references

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Correspondence to Mónica Flores-Ramos.

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Flores-Ramos, M., Heinze, G. & Silvestri-Tomassoni, R. Association between depressive symptoms and reproductive variables in a group of perimenopausal women attending a menopause clinic in México City. Arch Womens Ment Health 13, 99–105 (2010). https://doi.org/10.1007/s00737-009-0107-0

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  • DOI: https://doi.org/10.1007/s00737-009-0107-0

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