Skip to main content

Advertisement

SpringerLink
Log in

Use of cyanoacrylate adhesives in general surgery

  • Review Article
  • Published:
Surgery Today Aims and scope Submit manuscript

Abstract

This paper presents a review of the use of cyanoacrylate adhesives (CA) in general surgery and digestive surgery, studies the mechanisms of action and interactions of CAs in adherent tissues, and compiles data on the latest experimental and clinical applications. More than seven million traumatic injuries are estimated to occur every year, and between 26 and 90 million surgical procedures using different techniques are performed to close the resulting wounds. Traditional methods not only are both useful and effective, but also have some drawbacks. This review covers a considerable number of surgical procedures for which CAs had satisfactory results. The adhesive facilitated the healing of very diverse tissues, such as solid organs, vascular tissue or the abdominal wall. In other cases, no significant differences were found when CA was compared to traditional methods, with the adhesive standing out as a simple and reliable solution. The number of procedures in which CA was detrimental was very low. This review also collects and describes these. In conclusion, the surgical fields and procedures in which CA was successfully used are highly diverse. This review will allow physicians to determine which techniques were first used experimentally, but finally settled in clinical practice as feasible alternatives to standard treatments.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Arribas JM, Castelló JR, Rodríguez N, Sánchez A, Marín M. Suturas básicas y avanzadas en cirugía menor (III). Semergen. 2002;28(1):89–100.

    Google Scholar 

  2. Jackson MR, Friedman SA, Carter AJ, Bayer V, Burge JR, MacPhee MJ, Drohan WN, et al. Hemostatic efficacy of a fibrin sealant-based topical agent in a femoral artery injury model: a randomized, blinded, placebo-controlled study. J Vasc Surg. 1997;26:274–80.

    CAS  PubMed  Google Scholar 

  3. Holcomb JB, Pusateri AE, Hess JR, Hetz SP, Harris RA, Tock BB, Drohan WN, et al. Implications of new dry fibrin sealant technology for trauma surgery. Surg Clin N Am. 1997;77:943–52.

    CAS  PubMed  Google Scholar 

  4. Quinn JV, Drzewiecki A, Li MM, Stiell IG, Sutcliffe T, Elmslie TJ, Wood WE. A randomized, controlled trial comparing a tissue adhesive with suturing in the repair of pediatric facial lacerations. Ann Emerg Med. 1993;22:1130–5.

    CAS  PubMed  Google Scholar 

  5. Singer AJ, Hollander JE, Valentine SM, Turque TW, McCuskey CF, Quinn JV. Prospective randomized controlled trial of a new tissue adhesive (2-octylcyanoacrylate) versus standard wound closure techniques for laceration repair. Acad Emerg Med. 1998;5:94–8.

    CAS  PubMed  Google Scholar 

  6. Coover HN, Joyner FB, Sheere NH. Chemistry and performance of cyanoacrylate adhesive. J Soc Plast Surg Engl. 1959;15:5–6.

    Google Scholar 

  7. Trott AT. Cyanoacrylate tissue adhesives. An advance in wound care. JAMA. 1997;277:1559–60.

    CAS  PubMed  Google Scholar 

  8. Penoff J. Skin closures using cyanoacrylate tissue adhesives. Plastic Surgery Educational Foundation DATA Committee Device and Technique Assessment. Plast Reconstr Surg. 1999;103:730–1.

    CAS  PubMed  Google Scholar 

  9. Hollander JE, Singer AJ. Laceration management. Ann Emerg Med. 1999;34:356–67.

    CAS  PubMed  Google Scholar 

  10. Schonauer F, Pereira J, La Rusca I, Harris J, Cullen K. Use of Indermil tissue adhesive for closure of superficial skin lacerations in children. Minerva Chir. 2001;56(4):427–9.

    CAS  PubMed  Google Scholar 

  11. Van den Ende ED, Vriens PW, Allema JH, Breslau PJ. Adhesive bonds or percutaneous absorbable suture for closure of surgical wounds in children. Results of a prospective randomized trial. J Pediatr Surg 2004;39(8):1249–51.

  12. Matsumoto T, Pani KC, Hardaway RM, Leonard F. N-Alkyl-alphacyanoacrylatemonomers in surgery. Speed of polymerization and method of their application. Arch Surg. 1967;94:153–6.

    CAS  PubMed  Google Scholar 

  13. Quinn JV. Tissue adhesives in clinical medicine. 2ND ed. Ontario: BC Decker; 2005.

    Google Scholar 

  14. Hollander JE, Singer AJ. Application of tissue adhesives: rapid attainment of proficiency. Stony Brook Octylcyanoacrylate Study Group. Acad Emerg Med. 1998;5:1012–7.

    CAS  PubMed  Google Scholar 

  15. Toriumi DM, Raslan WF, Friedman M, Tardy ME. Histotoxicity of cyanoacrylate tissue adhesives. A comparative study. Arch Otolaryngol Head Neck Surg. 1990;116:546–50.

    CAS  PubMed  Google Scholar 

  16. Pani KC, Gladieux G, Brandes G, Kulkarni RK, Leonard F. The degradation of n-butyl alpha-cyanoacrylate tissue adhesive. II. Surgery. 1968;63:481–9.

    CAS  PubMed  Google Scholar 

  17. Woodward SC, Herrman JB, Cameron JL, Brandes G, Pulaski EJ, Leonard F. Histotoxicity of cyanoacrylate tissue adhesive in the rat. Ann Surg. 1965;162:113.

    CAS  PubMed Central  PubMed  Google Scholar 

  18. Ousterhout DK, Gladieux GV, Leonard F. Cutaneous absorption of n-alkyl alpha-cyanoacrylate. J Biomed Mater Res. 1968;2:157–63.

    CAS  PubMed  Google Scholar 

  19. Wang AA, Martin CH. Full-thickness skin necrosis of the fingertip after application of superglue. J Hand Surg. 2003;28:696–8.

    CAS  Google Scholar 

  20. Papatheofanis FJ. Prothrombotic cytotoxicity of cyanoacrylate tissue adhesive. J Surg Res. 1989;47(4):309–12.

    CAS  PubMed  Google Scholar 

  21. Ciapetti G, Stea S, Cenni E, Sudanese A, Marraro D, Toni A, Pizzoferrato A, et al. Cytotoxicity testing cyanoacrylates using direct contact assay on cell cultures. Biomaterials. 1994;15(1):63–7.

    CAS  PubMed  Google Scholar 

  22. Singer AJ, Quinn JV, Hollander JE. The cyanoacrylate topical skin adhesives. Am J Emerg Med. 2008;26(4):490–6.

    PubMed  Google Scholar 

  23. Batista CA, Colleoni Neto R, de Lopes Filho JG. Comparative study of the healing process of the aponeurosis of the anterior abdominal wall of rats after wound closure using 3-0 nylon suture and N-butil-2-cyanoacrylate tissue adhesive. Acta Cir Bras. 2008;23(4):352–63.

    PubMed  Google Scholar 

  24. Fontes CER, Taha MO, Fagundes DJ, Ferreira MV, Prado OR, Mardegan MJ. Estudo comparativo do uso de cola de fibrina e cianoacrilato em ferimento de fígado de rato. Acta Cir Bras. 2004;19(1):37–42.

    Google Scholar 

  25. Fotiadis C, Leventis I, Adamis S, Gorgoulis V, Domeyer P, Zografos G, Sechas M, Skalkeas G. The use of isobutyl cyanoacrylate as a tissue adhesive in abdominal surgery. Acta Chir Belg. 2005;105(4):392–6.

    CAS  PubMed  Google Scholar 

  26. Dávila F, Islas HG, Carbonell JM, Hernández LM, Sánchez DJ, Rivera JM. Uso del 2 cianoacrilato de N-butilo en lareparación primaria de heridas penetrantes en hígado, bazo e intestino delgado: modelo experimental en perros. Rev Sanid Milit Mex. 2009;63(4):182–8.

    Google Scholar 

  27. Kumar M, Mansour P, Vesey SG. Reducing laparoscopic radical prostatectomy false-positive margin rates using cyanoacrylate tissue glue. Eur Urol. 2009;56(4):651–8.

    PubMed  Google Scholar 

  28. Rojas D, Hernández AD, Sánchez RA. Cianoacrilato: hemostático en trauma hepático. Estudio experimental en modelo animal. Cir. Gen. 2010;32(3):170–4.

    Google Scholar 

  29. Lämsä T, Jin HT, Sand J, Nordback I. Tissue adhesives and the pancreas: biocompatibility and adhesive properties of 6 preparations. Pancreas. 2008;36(3):261–6.

    PubMed  Google Scholar 

  30. Bigolin S, Fagundes DJ, Rivoire HC, Fagundes AT, Fagundes AL. Transcervical hysteroscopic sterilization using cyanoacrylate: a long-term experimental study on sheep. J Obstet Gynaecol Res. 2009;35(6):1012–8.

    CAS  PubMed  Google Scholar 

  31. Ellman PI, Reece TB, Maxey TS, Tache-Leon C, Taylor JL, Spinosa DJ, Pineros-Fernandez AC, et al. Evaluation of an absorbable cyanoacrylate adhesive as a suture line sealant. J Surg Res. 2005;125(2):161–7.

    CAS  PubMed  Google Scholar 

  32. Wei W, Zhu Y, Wang J, Li Y, Li J. Cyanoacrylate-assisted arterial anastomosis in rat small bowel transplantation. Langenbecks Arch Surg. 2010;395(6):727–35.

    PubMed  Google Scholar 

  33. Zhu Y, Wei W, Li Y. 2-Octylcyanoacrylate-assisted microvascular anastomosis in rat orthotopic small bowel transplantation. J Reconstr Microsurg. 2011;27(3):151–6.

    PubMed  Google Scholar 

  34. Ersoy OF, Kayaoğlu HA, Celik A, Ozkan N, Lortlar N, Omeroğlu S. Comparison of cyanoacrylate-assisted arteriotomy closure with conventional closure technique. Ulus Travma Acil Cerrahi Derg. 2009;15(6):535–40.

    PubMed  Google Scholar 

  35. Rolland PH, Vidal V, Mekkaoui C, Bertrand MF, Levrier O, Bartoli JM. Embolization-driven occlusion of the abdominal aortic aneurismal sac as the basis of prevention of endoleaks in a new swine model. Eur J Endovasc Surg. 2006;31:28–35.

    CAS  Google Scholar 

  36. De Baere T, Denys A, Paradis V. Comparison of four embolic materials for portal vein embolization: experimental study in pigs. Eur Radiol. 2009;19(6):1435–42.

    PubMed  Google Scholar 

  37. Belletrutti PJ, Romagnuolo J, Hilsden RJ, Chen F, Kaplan B, Love J, Beck PL. Endoscopic management of gastric varices: efficacy and outcomes of gluing with N-butyl-2-cyanoacrylate in a North American patient population. Can J Gastroenterol. 2008;22(11):931–6.

    CAS  PubMed Central  PubMed  Google Scholar 

  38. Ikoma A, Kawai N, Sato M, Sonomura T, Minamiguchi H, Nakai M, Takasaka I, et al. Ischemic effects of transcatheter arterial embolization with N-butyl cyanoacrylate-lipiodol on the colon in a Swine model. Cardiovasc Interv Radiol. 2010;33(5):1009–15.

    Google Scholar 

  39. Singh A, Brisson BA, O’Sullivan ML, Solomon JA, Malek S, Nykamp S, Thomason JJ. Feasibility of percutaneous catheterization and embolization of the thoracic duct in dogs. Am J Vet Res. 2011;72(11):1527–34.

    PubMed  Google Scholar 

  40. Johnson WK, Kelel KM, Hollenbeck BK, Daignault S, Wolf JS Jr. Acute integrity of closure for partial nephrectomy: comparison of 7 agents in a hypertensive porcine model. J Urol. 2006;175(6):2307–11.

    Google Scholar 

  41. Bertleff MJ, Liem RS, Bartels HL, Robinson PH, Van der Werff JF, Bonjer HJ, Lange JF. The “stamp method”: a new treatment for perforated peptic ulcer? Surg Endosc. 2006;20(5):791–3.

    CAS  PubMed  Google Scholar 

  42. Fortelny RH, Petter-Puchner AH, Walder N, Mittermayr R, Ohlinger W, Heinze A, Redl H. Cyanoacrylate tissue sealant impairs tissue integration of macroporous mesh in experimental hernia repair. Surg Endosc. 2007;21(10):1781–5.

    CAS  PubMed  Google Scholar 

  43. Ladurner R, Drosses I, Seitz S, Plitz W, Barbaryka G, Siebeck M, Bürklein D, et al. Tissue attachment strength and adhesion formation of Intraabdominal fixed meshes with cyanoacrylate glues. Eur J Med Res. 2008;13:1–7.

    Google Scholar 

  44. Dilege E, Deveci U, Erbil Y, Dinççağ A, Seven R, Ozarmagan S, Mercan S, et al. N-butyl cyanoacrylate versus conventional suturing for fixation of meshes in an incisional hernia model. J Invest Surg. 2010;23(5):262–6.

    PubMed  Google Scholar 

  45. Losi P, Burchielli S, Spiller D, Finotti V, Kull S, Briganti E, Soldani G. Cyanoacrylate surgical glue as an alternative to suture threads for mesh fixation in hernia repair. J Surg Res. 2010;163(2):53–8.

    Google Scholar 

  46. Kukleta JF, Freytag C, Weber M. Efficiency and safety of mesh fixation in laparoscopic inguinal hernia repair using n-butyl cyanoacrylate: long-term biocompatibility in over 1,300 mesh fixations. Hernia. 2012;16(2):153–62.

    CAS  PubMed Central  PubMed  Google Scholar 

  47. Ladurner R, Drosse I, Bürklein D, Plitz W, Barbaryka G, Kirchhoff C, Kirchhoff S, et al. Cyanoacrylate glue for intra-abdominal mesh fixation of polypropylene-polyvinylidene fluoride meshes in a rabbit model. J Surg Res. 2011;167(2):157–62.

    Google Scholar 

  48. Ozmen MM, Ozalp N, Zulfikaroglu B, Abbasoglu L, Kacar A, Seckin S, Koc M. Histoacryl blue versus sutured left colonic anastomosis: experimental study. ANZ J Surg. 2004;74(12):1107.

    PubMed  Google Scholar 

  49. Nursal TZ, Anarat R, Bircan S, Yildirim S, Tarim A, Haberal M. The effect of tissue adhesive, octyl-cyanoacrylate, on the healing of experimental high-risk and normal colonic anastomoses. Am J Surg. 2004;187(1):28–32.

    CAS  PubMed  Google Scholar 

  50. Farías-Llamas OA, Orozco-Mosqueda A, Portilla-del Buen E, Leal-Cortés CA, Ruiz-Chávez IE, González-Ojeda A. Bursting pressure in normal and ischemic colonic anastomoses in rats; using biological and synthetic adhesives. Cir Cir. 2005;73(1):31–42.

    PubMed  Google Scholar 

  51. Saygun O, Topaloglu S, Avsar FM, Ozel H, Hucumenoglu S, Sahin M, Hengirmen S. Reinforcement of the suture line with an ePTFE graft attached with histoacryl glue in duodenal trauma. Can J Surg. 2006;49(2):107–12.

    PubMed Central  PubMed  Google Scholar 

  52. Escalante O, García G, Rocío A, Reyes L, Flores M, Rivera JM. Adhesivo tisular 2-octil cianoacrilato en el cierre de enterotomía comparado con sutura manual tradicional en dos capas. Modelo en perros. Cir Ciruj. 2009;77:121–5.

    Google Scholar 

  53. Faion AG, Diogo Filho A, de Alcantara TM, Ferreira TF. Ethyl-2-cyanoacrylate as a sealant after partial cecum resection in rattus norvegicus albinus. Rev Col Bras Cir. 2011;38(1):45–53.

    PubMed  Google Scholar 

  54. Elemen L, Sarimurat N, Ayik B, Aydin S, Uzun H. Is the use of cyanoacrylate in intestinal anastomosis a good and reliable alternative? J Pediatr Surg. 2009;44(3):581–6.

    PubMed  Google Scholar 

  55. Gómez JMA, Luna J, Soto BA, Hernández MC. Valoración de la cicatrización temprana en anastomosis intestinales con uso de adhesivo tisular (n-butil 2-octilcianoacrilato) versus técnica convencional. Acta Médica Grupo Ángeles. 2009;7(3):137–42.

    Google Scholar 

  56. Irkorucu O, Ucan BH, Cakmak GK, Tascilar O, Emre AU, Ofluoglu E, Bahadir B, et al. Effect of 2-octyl-cyanoacrylate on ischemic anastomosis of the left colon. J Invest Surg. 2009;22(3):188–94.

    PubMed  Google Scholar 

  57. Kayaoglu HA, Ersoy O, Ozkan N, Celik A, Onuk N. Effect of n-butyl-2-cyanoacrylate on high-risk colonic anastomoses. Med Sci. 2009;25:177–83.

    CAS  Google Scholar 

  58. Soares Júnior C, Souza C. The use of 2-octyl cyanoacrylate in colonic anastomosis: experimental study in Wistar rats. Rev Col Bras Cir 2010;37(2):128–34.

  59. Bae KB, Kim SH, Jung SJ, Hong KH. Cyanoacrylate for colonic anastomosis; is it safe? Int J Colorectal Dis. 2010;25(5):601–6.

    PubMed  Google Scholar 

  60. Paral J, Subrt Z, Lochman P, Klein L, Hadzi-Nikolov D, Turek Z, Vejbera M. Suture-free anastomosis of the colon experimental comparison of two cyanoacrylate adhesives. J Surg Gastrointest. 2011;15(3):451–9.

    Google Scholar 

  61. Ensari CO, Genc V, Cakmak A, Erkek B, Karayalcin K. Effects of N-butyl-2-cyanoacrylate on high-level jejunojejunostomy. Eur Surg Res. 2010;44(1):13–6.

    CAS  PubMed  Google Scholar 

  62. Repici A, Ferrari A, De Angelis C, Caronna S, Barletti C, Paganin S, Musso A, et al. Adrenalina plus cyanoacrylate injection for treatment of bleeding peptic ulcers alter failure of conventional endoscopic haemostasis. Dig Liver Dis. 2002;24(5):349–55.

    Google Scholar 

  63. Seewald S, Sriram PVJ, Naga M, Fennerty MB, Boyer J, Oberti F, Soehendra N. Cyanoacrylate glue in gastric variceal bleeding. Endoscopy. 2002;34(119):926–32.

    CAS  PubMed  Google Scholar 

  64. Esposito C, Damiano R, Settimi A, De Marco M, Maglio P, Centone A. Experience with the use of tissue adhesives in pediatric endoscopy surgery. Surg Endosc. 2004;18:290–2.

    CAS  PubMed  Google Scholar 

  65. Al-Fraij AK, Dhar PM, Al-Khalejy A, Abu Najem F. Massive hemorrhage from spontaneous ruptured hepatocellular carcinoma controlled by isoamyl 2-cyanoacrylate: a case report. Med Princ Pract. 2011;20(3):297–9.

    PubMed  Google Scholar 

  66. Borley NR, Mortensen NJ. Topical adhesive as a wound dressing for elective abdominal surgery. Ann R Coll Surg Engl. 2001;83(4):285–6.

    CAS  PubMed Central  PubMed  Google Scholar 

  67. Cuschieri A. Tissue adhesives in endosurgery. Semin Laparosc Surg. 2001;8(1):63–8.

    CAS  PubMed  Google Scholar 

  68. Jaibaji M. Topical adhesive as a wound dressing for elective abdominal surgery. Ann R Coll Surg Engl. 2002;84(3):221.

    PubMed Central  PubMed  Google Scholar 

  69. Ong J, Ho KS, Chew MH, Eu KW. Prospective randomised study to evaluate the use of DERMABOND ProPen (2-octylcyanoacrylate) in the closure of abdominal wounds versus closure with skin staples in patients undergoing elective colectomy. Int J Colorectal Dis. 2010;25(7):899–905.

    PubMed  Google Scholar 

  70. Ferlise VJ, Ankem MK, Barone JG. Use of cyanoacrylate tissue adhesive under a diaper. BJU Int. 2001;87(7):672–3.

    CAS  PubMed  Google Scholar 

  71. Esposito C. L’utilisasion d’une Nouvelle Colle Chirurgicale en Chirurgie Laparoscopique: quels advantages? J Coel Chirur 1997;23:66–8.

  72. Mitolo CI, Vincenti L, Stabile-Ianora AA, Prete F. Total cyst excision by laparoscopic splenic resection. Surg Endosc 2001;15(2):219.

  73. Rosin D, Rosenthal RJ, Kuriansky J, Brasesco O, Shabtai M, Ayalon A. Closure of laparoscopic trocar site wounds with cyanoacrylate tissue glue: a simple technical solution. J Laparoendosc Adv Surg Tech A. 2001;11(3):157–9.

    CAS  PubMed  Google Scholar 

  74. Barto W. Randomized study of the effectiveness of closing laparoscopic trocar wounds with octylcyanoacrylate, adhesive papertape or poliglecaprone. Br J Surg. 2002;89:1370–5.

    Google Scholar 

  75. Dowson CC, Gilliam AD, Speake WJ, Lobo DN, Beckingham IJ. A prospective, randomized controlled trial comparing n-butyl cyanoacrylate tissue adhesive (LiquiBand) with sutures for skin closure after laparoscopic general surgical procedures. Surg Endosc Laparosc Percutaneous Tech. 2006;16(3):146–50.

    Google Scholar 

  76. Maartense S, Bemelman WA, Dunker MS, De Lint C, Pierik EGJM, Busch ORC, Gouma DJ. Randomized study of the effectiveness of closing laparoscopic trocar wounds with octylcyanoacrylate, adhesive papertape or poliglecaprone. Br J Surg. 2002;89:1370–5.

    CAS  PubMed  Google Scholar 

  77. Helbling C, Schlumpf R. Sutureless Lichtenstein: first results of a prospective randomized clinical trial. Hernia. 2003;7(2):80–4.

    PubMed  Google Scholar 

  78. Sebesta MJ, Bishoff JT. Octylcyanoacrylate skin closure in laparoscopy. J Endourol. 2003;17(10):899–903.

    PubMed  Google Scholar 

  79. Switzer EF, Dinsmore RC, North JH Jr. Subcuticular closure versus dermabond: a prospective randomized trial. Am Surg. 2003;69(5):434–6.

    PubMed  Google Scholar 

  80. Jallali N, Haji A, Watson CJ. A prospective randomized trial comparing 2-octyl cyanoacrylate to conventional suturing in closure of laparoscopic cholecystectomy incisions. J Laparoendosc Adv Surg Tech A. 2004;14(4):209–11.

    PubMed  Google Scholar 

  81. Sajid MS, Siddiqui MR, Khan MA, Baig MK. Meta-analysis of skin adhesives versus sutures in closure of laparoscopic port-site wounds. Clin Endosc. 2009;23(6):1191–7.

    Google Scholar 

  82. Nowobilski W, Dobosz M, Wojciechowicz T, Mionskowska L. Lichtenstein inguinal hernioplasty using butyl-2-cyanoacrylate versus sutures. Preliminary experience of a prospective randomized trial. Eur Surg Res. 2004;36(6):367–70.

    CAS  PubMed  Google Scholar 

  83. Sebesta MJ, Bishoff JT, Jay MD. Octylcyanoacrylate skin closure in laparoscopy. JSLS. 2004;8(1):9–14.

    PubMed Central  PubMed  Google Scholar 

  84. Chen K, Klapper AS, Voige H, Del Priore G. A randomized, controlled study comparing two standardized closure methods of laparoscopic port sites. JSLS. 2010;14(3):391–4.

    PubMed Central  PubMed  Google Scholar 

  85. Matin SF. Prospective randomized trial of skin adhesive versus sutures for closure of 217 laparoscopic port-site incisions. J Am Coll Surg. 2003;196(6):845–53.

    PubMed  Google Scholar 

  86. Harold KL, Goldstein SL, Nelms CD, Matthews BD, Sing RF, Kercher KW, Lincourt A, et al. Optimal closure method of five-millimeter trocar sites. Am J Surg. 2004;187(1):24–7.

    PubMed  Google Scholar 

  87. Nordkild P, Hjortrup A, Kjaergaard J. Tissue adhesives and intestinal anastomosis. Ann Chir Gynaecol. 1986;75(4):205–8.

    CAS  PubMed  Google Scholar 

  88. Roque R, García A, Guerra RM, Leal A, Mursulí A, Zambrana FR, Cruz A. Utilización del Tisuacryl® en la anastomosis del esófago con otros segmentos del tubo digestivo. Rev Cubana Cir. 2006;45:2.

    Google Scholar 

  89. Ortiz De Zarate J, Calderon AJ, Ruiz P, Diaz AB, Cabezudo P, Polo F, Marcé L, et al. Uso de pegamento y clips metalicos para el sellado endoscopico de perforacion gastrica yatrogena. Gastroenterol Hepatol. 2006;29(2):107–11.

    PubMed  Google Scholar 

  90. Drury AE, Grundy A. Management of oesophageal fistula by radiologically-guided instillation of tissue adhesive. Clin Radiol. 1995;50(5):335–7.

    CAS  PubMed  Google Scholar 

  91. Rotondano G, Viola M, Orsini L, Cipolletta F, Bianco MA, Garofano ML, Cipolleta L. Uncommon cause of early postoperative colonic fistula successfully treated with endoscopic acrylate glue injection. Gastrointest Endosc. 2008;67(1):183–6.

    PubMed  Google Scholar 

  92. Bae JH, Kim GC, Ryeom HK, Jang YJ. Percutaneous embolization of persistent biliary and enteric fistulas with Histoacryl. J Vasc Interv Radiol. 2011;22(6):879–83.

    PubMed  Google Scholar 

  93. Labas P, Ohrádka B, Cambal M, Fillo J. Pancreatic duct occlusion with acrylic glue. Przegl Lek. 2003;60(12):789–91.

    PubMed  Google Scholar 

  94. Alfieri S, Di Miceli D, Pericoli M, Ridolfini F, Rotondi A, Di GiorgioG B. Occlusione del dotto pancreatico dopo duodeno-cefalopancreasectomia. Doglietto Osp Ital Chir. 2006;12:1.

    Google Scholar 

  95. Capaldi M, Alessandroni L, Barreca M, Campanelli A, De Siena T, Ricci G, Sorgi G, et al. Trattamento del moncone pancreatico residuo con cianoacrilato dopo duodeno-cefalopancreasectomia. Osp Ital Chir. 2006;12:1.

    Google Scholar 

  96. Sofuni A, Itoi T, Tsuchiya T, Itokawa F, Kurihara T, Moriyasu F, Kawai T. Endoscopic sealing of a pancreatic fistula using ethyl-2-cyanoacrylate. Endoscopy. 2006;38(2):71–2.

    Google Scholar 

  97. Romano A, Spaggiari M, Masetti R, Sassatelli F, Di Benedetto N, De Ruvo R, Montalti R, et al. A new endoscopic treatment for pancreatic fistula after distal pancreatectomy: case report and review of the literature. Congresso Eur Surg 2008;40:61–183.

  98. Labori KJ, Trondsen E, Buanes T, Hauge T. Endoscopic sealing of pancreatic fistulas: four case reports and review of the literature. Scand J Gastroenterol. 2009;44(12):1491–6.

    PubMed  Google Scholar 

  99. Farouk R, Drew PJ, Qureshi A, Roberts AC, Duthie GS, Monson JR. Preliminary experience with butyl-2-cyanoacrylate adhesive in tension-free inguinal hernia repair. Br J Surg. 1996;83(8):1100.

    CAS  PubMed  Google Scholar 

  100. Jourdan IC, Bailey ME. Initial experience with the use of N-butyl 2-cyanoacrylate glue for the fixation of polypropylene mesh in laparoscopic hernia repair. Surg Laparosc Endosc. 1998;8(4):291–3.

    CAS  PubMed  Google Scholar 

  101. Agresta F, Baldazzi GA, Ciardo LF, Trentin G, Sansonetti G, Ferrante F, Bedin N. Lightweight partially absorbable monofilament mesh (polypropylene/poliglecaprone 25) for TAPP inguinal hernia repair: initial experience. Surg Laparosc Endosc Percutaneous Tech. 2007;17(2):91–4.

    Google Scholar 

  102. Rocha M. Hernioplastia inguinal con malla sin tensión. Experiencia con adhesivo N-butil. Rev Chil Cir. 2008;60(2):98–102.

    Google Scholar 

  103. Paajanen H, Kössi J, Silvasti S, Hulmi T, Hakala T. Randomized clinical trial of tissue glue versus absorbable sutures for mesh fixation in local anaesthetic Lichtenstein hernia repair. Br J Surg. 2011;98(9):1245–51.

    CAS  PubMed  Google Scholar 

  104. Shen YM, Sun WB, Chen J, Liu SJ, Wang MG. NBCA medical adhesive (n-butyl-2-cyanoacrylate) versus suture for patch fixation in Lichtenstein inguinal herniorrhaphy: a randomized controlled trial. Surgery. 2012;151(4):550–5.

    PubMed  Google Scholar 

  105. Testini M, Lissidini G, Poli E, Gurrado A, Lardo D, Piccinni G. A single-surgeon randomize trial comparing sutures, N-butyl-2-cyanoacrylate and human fibrin glue for mesh fixation during primary inguinal hernia repair. Can J Surg. 2010;53(3):155–60.

    PubMed Central  PubMed  Google Scholar 

  106. Domingo C, Alberola A, Peiró F, Bertelli J, de la Morena E. Reparación por vía laparoscopia de una hernia intercostal abdominal. Cir Esp. 2008;84(2):101–11.

    Google Scholar 

  107. Battaglia G, Morbin T, Patarnello E, Carta A, Coppa F, Ancona A. Diagnostic et traitement endoscopique des varices gastriques. Acta Endoscopica. 1999;29(2):97–107.

    Google Scholar 

  108. Rollán A. Várices gástricas: Fisiopatología, clínica y tratamiento. Gastr Latinoam. 2007;18(1):81–8.

    Google Scholar 

  109. Serpa H, Figueroa R. Manejo del sangrado agudo por varices esófago gástricas. Rev Gastroenterol Peru. 1998;18(1):38–43.

    PubMed  Google Scholar 

  110. Seewald S, Seitz U, Yang AM. Variceal bleeding and portal hypertensions: still a therapeutic challenge? Endoscopy. 2001;33(2):126–39.

    CAS  PubMed  Google Scholar 

  111. Mahadeva S, Bellamy MC, Kessel D, Davies MH, Millson CE. Cost-effectiveness of N-butyl-2-cyanoacrylate (histoacryl) glue injections versus transjugular intrahepatic portosystemic shunt in the management of acute gastric variceal bleeding. Am J Gastroenterol. 2003;98(12):2688–93.

    CAS  PubMed  Google Scholar 

  112. Noophun P, Kongkam P, Gonlachanvit S, Rerknimitr R. Bleeding gastric varices: results of endoscopic injection with cyanoacrylate at King Chulalongkorn Memorial Hospital. World J Gastroenterol. 2005;11(47):7531–5.

    PubMed  Google Scholar 

  113. Ryu SH, Jeong D, Moon S, Kim II, Kim YS, Lee JH. Endoscopic injection sclerotherapy with N-butyl-2-cyanoacrylate in a patient with massive rectal variceal bleeding: a case report. Gastrointest Endosc. 2005;62(4):632–5.

    PubMed  Google Scholar 

  114. Mumtaz K, Majid S, Shah H, Hameed K, Ahmed A, Hamid S, Jafri W. Prevalence of gastric varices and results of sclerotherapy with N-butyl 2 cyanoacrylate for controlling acute gastric variceal bleeding. World J Gastroenterol. 2007;13(8):1247–51.

    CAS  PubMed Central  PubMed  Google Scholar 

  115. Onozato Y, Kakizakib S, Iizukaa H, Moria K, Takizawaa D, Ohyamaa T, Arakawa K, et al. Ectopic varices rupture in the gastroduodenal anastomosis successfully treated with N-butyl-2-cyanoacrylate injection. Acta Med Okayama. 2007;61(6):361–5.

    PubMed  Google Scholar 

  116. Suhimoto N, Watanabe K, Watanabe K, Ogata S, Shimoda R, Sakata H, Equchi Y, et al. Endoscopic hemostasis for bleeding gastric varices treated by combination of varicela ligation and sclerotherapy with N-butyl-2-cyanoacrylate. J Gastroenterol. 2007;42:528–32.

    Google Scholar 

  117. Zumaeta E. Várices esofagogástricas. Acta Med Per. 2007;24(1):47–52.

    Google Scholar 

  118. Maruyama H, Okabe S, Ishihara T, Tsuyuguchi T, Yoshikawa M, Matsutani S, Yokosuka O. Long-term effect of endoscopic injection therapy with combined cyanoacrylate and ethanol for gastric fundal varices in relation to portal hemodynamics. Abdom Imaging. 2010;35(1):8–14.

    PubMed  Google Scholar 

  119. Wahl P, Lammer F, Conen D, Schlumpf R, Bock A. Septic complications after injection of N-butyl-2-cyanoacrylate: report of two cases and review. Gastrointest Endosc. 2004;59(7):911–6.

    PubMed  Google Scholar 

  120. Neumann H, Scheidbach H, Mönkemüller K, Pech M, Malfertheiner P. Multiple cyanoacrylate (Histoacryl) emboli after injection therapy of cardia varices. Gastrointest Endosc. 2009;70(5):1025–6.

    PubMed  Google Scholar 

  121. Galperine T, Flateau C, Venon MD, Lescure FX, Béraud G, Said Ibrahim T, Delisle F, et al. Recurrent bacteremia: a complication of cyanoacrylate injection for variceal bleeding: report of two cases and review of the literature. Case Rep Med 2009;2009:1–3.

  122. Cheng LF, Wang ZQ, Li CZ, Cai FCh, Huang QY, Linghu EG, Li W, et al. Treatment of gastric varices by endoscopic sclerotherapy using butyl cyanoacrylate: 10 years’ experience of 635 cases. Chin Med J. 2007;120(23):2081–5.

    PubMed  Google Scholar 

  123. Cheng LF, Wang ZQ, Li CZ, Lin W, Yeo AE, Jin B. Low incidence of complications from endoscopic gastric variceal obturation with butyl cyanoacrylate. Clin Gastroenterol Hepatol. 2010;8(9):760–6.

    CAS  PubMed  Google Scholar 

  124. Cantasdemir M, Adaletli I, Cebi D, Kantarci F, Selcuk ND, Numan F. Emergency endovascular embolization of traumatic intrarenal arterial pseudoaneurysms with N-butyl cyanoacrylate. Clin Radiol. 2003;58:560–5.

    CAS  PubMed  Google Scholar 

  125. Kim BS, Do HM, Razavi M. N-Butyl cyanoacrylate glue embolization of splenic arteryaneurysms. J Vasc Interv Radiol. 2004;15(1):91–4.

    PubMed  Google Scholar 

  126. Laganà D, Carrafiello G, Mangini M, Fontana F, Dizonno M, Castelli P, Fugazzola C. Endovascular treatment of splenic artery aneurysms. Radiol Med. 2005;110(1–2):77–87.

    PubMed  Google Scholar 

  127. Ishikawa M, Kakizawa H, Yamasaki W, Date S, Hieda M, Kajiwara K, Awai K. Recanalization after successful occlusion by transcatheter arterial embolization with N-butyl cyanoacrylate for traumatic splenic artery injury. Hiroshima J Med Sci. 2011;60(4):87–90.

    CAS  PubMed  Google Scholar 

  128. Núñez MH, Calerob H, Velicia R, García F, Sánchez G, Caro A. Fístula arterioportal sintomática resuelta mediante tratamiento conservador. Gastroenterol Hepatol. 2006;29(4):237–9.

    Google Scholar 

  129. Yoshimatsu R, Takeuchi Y, Morishita H, Iida N, Okabe H, Yamagami T, Nishimura T. Successful embolisation of intrahepatic portosystemic venous shunt using coils and n-butyl cyanoacrylate through two approach routes. Br J Radiol. 2006;79(947):162–5.

    Google Scholar 

  130. Park SW, Choe WH, Lee CH, Lee MW, Kim YJ, Kwon SY, Jeon HJ. Transcatheter embolization of a pseudoaneurysm of the inferior epigastric artery with N-butyl cyanoacrylate. Br J Radiol. 2008;81:64–7.

    Google Scholar 

  131. Yamagami T, Kanda K, Kato T, Hirota T, Nishida K, Yoshimatsu R, Matsumoto T, et al. Embolisation of proximal anastomotic pseudoaneurysm developing after surgical repair of abdominal aortic aneurysm with a bifurcated graft with n-butyl cyanoacrylate. Br J Radiol. 2006;79:193–5.

    Google Scholar 

  132. Rusius VC, Davies RS, Hopkins JD, Duddy MJ, Smith SR. Successful glue embolization of a late type 1A endoleak causing abdominal aortic aneurysm rupture. Vasc Endovasc Surg. 2011;45(2):198–201.

    Google Scholar 

  133. Peynircioğlu B, Türkbey B, Ozkan M, Cil BE. Use of glue and microcoils for transarterial catheter embolization of a type 1 endoleak. Diagn Interv Radiol. 2008;14(2):111–5.

    Google Scholar 

  134. Gorlitzer M, Mertikian G, Trnka H, Froeschl A, Meinhart J, Weiss G, Grabenwoeger M, et al. Translumbar treatment of type II endoleaks after endovascular repair of abdominal aortic aneurysm. Interact Cardiovasc Thorac Surg. 2008;7:781–4.

    PubMed  Google Scholar 

  135. Buckenham T, McKewen M, Laing A, Roake J, Lewis D, Gordon MK. Cyanoacrylate embolization of endoleaks after abdominal aortic aneurysm repair. ANZ J Surg. 2009;79:841–3.

    PubMed  Google Scholar 

  136. Park SJ, Kwon SW, Oh JH, Park HC. Glue embolization of a ruptured celiac trunk aneurysm. Vascular. 2009;17(2):112–5.

    PubMed  Google Scholar 

  137. Chandra J, Anthony S, Uberoi R. Embolization of the internal iliac artery with Glubran 2 acrylic glue: initial experience with an adjunctive outflow occlusive agent. J Vasc Interv Radiol. 2010;21(7):1109–14.

    PubMed  Google Scholar 

  138. Park SW, Chang SH, Yun IJ, Lee HW. Deep circumflex iliac artery-related hemoperitoneum formation after surgical drain placement: successful transcatheter embolization. Cardiovasc Interv Radiol. 2010;33(2):402–5.

    Google Scholar 

  139. Kim SH, Kim SH, Cho JY. Cyst ablation using a mixture of N-butyl cyanoacrylate and iodized oil in patients with autosomal dominant polycystic kidney disease: the long-term results. Korean J Radiol. 2009;10(4):377–83.

    PubMed Central  PubMed  Google Scholar 

  140. Lauterio A, Slim A, Aseni P, Giacomoni A, Di Sandro S, Corso R, Mangoni I, et al. Percutaneous transhepatic bile duct ablation with n-butyl cyanoacrylate in the treatment of a biliary complication after split liver transplantation. J Transplant. 2009;2009:1–3.

  141. Weng SS, Wang YL. Leak-proof extracorporeal drainage for management of large ovarian tumors. Arch Gynecol Obstet. 2012;285(4):1079–82.

    PubMed  Google Scholar 

  142. Quinn JV, Ramotar K, Osmond MH. The antimicrobial effects of a new tissue adhesive. Acad Emerg Med. 1996;3:536–7.

    Google Scholar 

  143. Riskin DJ, Longaker MT, Gertner M, Krummel TM. Innovation in surgery: a historical perspective. Ann Surg. 2006;244(5):686–93.

    PubMed Central  PubMed  Google Scholar 

  144. Stirrat GM, Farrow SC, Farndon J, Dwyer N. The challenge of evaluating surgical procedures. Ann R Coll Surg Engl. 1992;74:80–4.

    CAS  PubMed Central  PubMed  Google Scholar 

Download references

Conflict of interest

David García Cerdá and the other co-authors have no conflicts of interest.

Author information

Authors and Affiliations

  1. Experimental Surgery, Universidad Católica de Valencia, C/Quevedo 2, 46001, Valencia, Spain

    David García Cerdá, Antonio Martín Ballester, Alicia Aliena-Valero, Anna Carabén-Redaño & José M. Lloris

  2. Department of Surgery, University of Valencia, Valencia, Spain

    José M. Lloris

Authors
  1. David García Cerdá
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Antonio Martín Ballester
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Alicia Aliena-Valero
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anna Carabén-Redaño
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. José M. Lloris
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to David García Cerdá.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

García Cerdá, D., Ballester, A.M., Aliena-Valero, A. et al. Use of cyanoacrylate adhesives in general surgery. Surg Today 45, 939–956 (2015). https://doi.org/10.1007/s00595-014-1056-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00595-014-1056-4

Keywords

Search

Navigation