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A new prognostic score for the survival of patients with esophageal squamous cell carcinoma

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Abstract

Purpose

Recent studies have shown that the modified Glasgow Prognostic Score (mGPS), which is an inflammation-based prognostic score, is useful as a prognostic index for some cancer cases. The purpose of this study was to create a prognostic scoring system for patients with esophageal squamous cell carcinoma (ESCC) that was more independent and sensitive than the mGPS.

Methods

One hundred sixty-eight patients who had undergone esophagectomy for ESCC were included in the study. The new mGPS (NmGPS) was calculated based on the following cutoff values: CRP >0.75 mg/dL indicated NmGPS 1 or 2, depending on the absence or presence of hypoalbuminemia (<3.5 g/dL); and CRP ≤0.75 mg/dL indicated NmGPS 0. We also performed an analysis based on cutoff values of 0.5 and 0.25 mg/dL for CRP.

Results

Only the NmGPS with a cutoff CRP value of 0.5 mg/dL was able to divide into three independent patient groups in the survival curves. In the multivariate analyses, a NmGPS (CRP cutoff; 0.5 mg/dL) of 2 was a more significant independent prognostic factor (HR 4.437, 95 % CI 2.000–9.844, p = 0.0002) than a mGPS of 2 (HR 2.726, 95 % CI 1.021–7.112, p = 0.0449).

Conclusions

The new prognostic score NmGPS (CRP cutoff; 0.5 mg/dL) was more independent and sensitive than the mGPS for patients with ESCC.

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Abbreviations

GPS:

Glasgow Prognostic Score

mGPS:

Modified Glasgow Prognostic Score

NmGPS:

New modified Glasgow Prognostic Score

CRP:

C-reactive protein

ESCC:

Esophageal squamous cell carcinoma

AIC:

Akaike information criterion

HR:

Hazard ratio

CI:

Confidence interval

SIR:

Systemic inflammatory response

IL-6:

Interleukin-6

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Conflict of interest

M. Nakamura and the co-authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Second Department of Surgery, School of Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8510, Japan

    Masaki Nakamura, Makoto Iwahashi, Mikihito Nakamori, Toshiyasu Ojima, Masahiro Katsuda, Takeshi Iida, Keiji Hayata, Tomoya Kato & Hiroki Yamaue

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  1. Masaki Nakamura
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  2. Makoto Iwahashi
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  3. Mikihito Nakamori
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  4. Toshiyasu Ojima
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  5. Masahiro Katsuda
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  6. Takeshi Iida
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  7. Keiji Hayata
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  8. Tomoya Kato
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  9. Hiroki Yamaue
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Corresponding author

Correspondence to Hiroki Yamaue.

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Nakamura, M., Iwahashi, M., Nakamori, M. et al. A new prognostic score for the survival of patients with esophageal squamous cell carcinoma. Surg Today 44, 875–883 (2014). https://doi.org/10.1007/s00595-013-0628-z

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  • DOI: https://doi.org/10.1007/s00595-013-0628-z

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