Abstract
Perioperative ischemic stroke occurs in approximately 0.08–0.7% of patients after non-cardiovascular surgery and confers a significant risk of morbidity and mortality. The mortality rate of this major complication is similar in non-cardiovascular and cardiovascular surgery. Its incidence appears to be similar in Japan, Europe, and the United States. Perioperative physicians should be aware of the pathophysiology and predictors of ischemic stroke, and the anti-thrombotic strategies to prevent it. The main causes of perioperative ischemic stroke include cerebral atherothrombosis; lacuna stroke; cardiac thrombi due to atrial fibrillation; dehydration; hypotension; and perioperative systemic hypercoagulability. Perioperative management includes detailed informed consent regarding potential stroke risks, counseling, careful surgical treatment decisions, and identification of the high-risk patient for perioperative antithrombotic strategies. The 2009 Japanese guidelines for the management of stroke recommend using the appropriate intravenous infusions to avoid dehydration and consideration of anticoagulation in the patients who are at high risk for thrombosis and embolism while antithrombotic agents are discontinued. Understanding how to prevent perioperative ischemic stroke remains a challenge. In this article, we review the incidence, timing of the occurrence, mortality, risk factors, and pathophysiology of perioperative ischemic stroke in the non-cardiovascular surgery patient.
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References
Selim M. Perioperative stroke. N Engl J Med. 2007;356:706–13.
Grocott HP, Yoshitani K. Neuroprotection during cardiac surgery. J Anesth. 2007;21:367–77.
Baba T, Goto T, Maekawa K, Ito A, Yoshitake A, Koshiji T. Early neuropsychological dysfunction in elderly high-risk patients after on-pump and off-pump coronary bypass surgery. J Anesth. 2007;21:452–8.
Bucerius J, Gummert JF, Borger MA, Walther T, Doll N, Onnasch JF, Metz S, Falk V, Mohr FW. Stroke after cardiac surgery: a risk factor analysis of 16,184 consecutive adult patients. Ann Thorac Surg. 2003;75:472–8.
Parikh S, Cohen JR. Perioperative stroke after general surgical procedures. N Y State J Med. 1993;93:162–5.
Limburg M, Wijdicks EF, Li H. Ischemic stroke after surgical procedures: clinical features, neuroimaging, and risk factors. Neurology. 1998;50:895–901.
Bateman BT, Schumacher HC, Wang S, Shaefi S, Berman MF. Perioperative acute ischemic stroke in noncardiac and nonvascular surgery: incidence, risk factors, and outcomes. Anesthesiology. 2009;110:231–8.
Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study. Lancet. 1997;349:1498–504.
Steg PG, Bhatt DL, Wilson PW, D’Agostino R Sr, Ohman EM, Rother J, Liau CS, Hirsch AT, Mas JL, Ikeda Y, Pencina MJ, Goto S. One-year cardiovascular event rates in outpatients with atherothrombosis. JAMA. 2007;297:1197–206.
Kikura M, Oikawa F, Yamamoto K, Iwamoto T, Tanaka KA, Sato S, Landesberg G. Myocardial infarction and cerebrovascular accident following non-cardiac surgery: differences in postoperative temporal distribution and risk factors. J Thromb Haemost. 2008;6:742–8.
Larsen SF, Zaric D, Boysen G. Postoperative cerebrovascular accidents in general surgery. Acta Anaesthesiol Scand. 1988;32:698–701.
Wong GY, Warner DO, Schroeder DR, Offord KP, Warner MA, Maxson PM, Whisnant JP. Risk of surgery and anesthesia for ischemic stroke. Anesthesiology. 2000;92:425–32.
Landercasper J, Merz BJ, Cogbill TH, Strutt PJ, Cochrane RH, Olson RA, Hutter RD. Perioperative stroke risk in 173 consecutive patients with a past history of stroke. Arch Surg. 1990;125:986–9.
Kikura M, Takada T, Sato S. Preexisting morbidity as an independent risk factor for perioperative acute thromboembolism syndrome. Arch Surg. 2005;140:1210–7 (discussion 8).
Hoffman M, Monroe DM 3rd. A cell-based model of hemostasis. Thromb Haemost. 2001;85:958–65.
Dahl OE. Mechanisms of hypercoagulability. Thromb Haemost. 1999;82:902–6.
McEver RP. Adhesive interactions of leukocytes, platelets, and the vessel wall during hemostasis and inflammation. Thromb Haemost. 2001;86:746–56.
Goel MS, Diamond SL. Neutrophil enhancement of fibrin deposition under flow through platelet-dependent and -independent mechanisms. Arterioscler Thromb Vasc Biol. 2001;21:2093–8.
Kikura M, Takada T, Sato S. Age- and sex-specific incidence, risk, and latency period of a perioperative acute thromboembolism syndrome (PATS). Thromb Haemost. 2004;91:725–32.
Kikura M, Ishiguro Y. Perioperative management of hemostasis and thrombosis in cardiovascular anesthesia (in Japanese with English Abstract). Nihon Rinsho Masui Gakkaishi (J Jpn Soc Clin Anesth). 2009;29:809–14.
Shinohara Y, The Joint Committee on Guidelines for the Management of Stroke. Japanese guidelines for the management of stroke 2009. Tokyo: Kyowa Kikaku (Corp.); 2009. p. 103–9.
Douketis JD, Berger PB, Dunn AS, Jaffer AK, Spyropoulos AC, Becker RC, Ansell J. The perioperative management of antithrombotic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133:299S–339S.
Sibon I, Orgogozo JM. Antiplatelet drug discontinuation is a risk factor for ischemic stroke. Neurology. 2004;62:1187–9.
Neilipovitz DT, Bryson GL, Nichol G. The effect of perioperative aspirin therapy in peripheral vascular surgery: a decision analysis. Anesth Analg. 2001;93:573–80.
Bode RH Jr, Lewis KP, Zarich SW, Pierce ET, Roberts M, Kowalchuk GJ, Satwicz PR, Gibbons GW, Hunter JA, Espanola CC. Cardiac outcome after peripheral vascular surgery. Comparison of general and regional anesthesia. Anesthesiology. 1996;84:3–13.
Rodgers A, Walker N, Schug S, McKee A, Kehlet H, van Zundert A, Sage D, Futter M, Saville G, Clark T, MacMahon S. Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials. BMJ. 2000;321:1493.
Iwamoto T, Itagaki T, Oikawa F, Kikura M, Hirano K, Sato S. The effect of general anesthesia on regional cerebral oxygen saturation and volume of hemoglobin in elderly patients. J Anesth. 2007;21(suppl):O57-07.
Iwamoto T, Oikawa H, Kume Y, Ishida C, Kikura M. Changes under anesthesia in cerebral hemoglobin density and oxygen saturation in elderly patients. Anesthesiology. 2008;109:A241.
Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA, Stiles RA, Dittus RS, Bernard GR, Ely EW. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007;298:2644–53.
Riker RR, Shehabi Y, Bokesch PM, Ceraso D, Wisemandle W, Koura F, Whitten P, Margolis BD, Byrne DW, Ely EW, Rocha MG. Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial. JAMA. 2009;301:489–99.
Acknowledgments
The authors are thankful to Dr. Kuniyoshi Tanaka (Department of Cardiothoracic and Vascular surgery, Hamamatsu Medical Center, Hamamatsu, Japan) for his thoughtful critiques and comments on this review article.
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Kikura, M., Bateman, B.T. & Tanaka, K.A. Perioperative ischemic stroke in non-cardiovascular surgery patients. J Anesth 24, 733–738 (2010). https://doi.org/10.1007/s00540-010-0969-3
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DOI: https://doi.org/10.1007/s00540-010-0969-3