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The effect of oral and IV ramosetron on postoperative nausea and vomiting in patients undergoing gynecological laparoscopy with total intravenous anesthesia

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Abstract

Purpose

Ramosetron can be administered orally as well as intravenously. We investigated the effect of oral ramosetron on postoperative nausea and vomiting (PONV) in patients undergoing gynecological laparoscopy.

Methods

One hundred and twenty women were allocated randomly to one of three groups (n = 40 in each) to receive saline (control), 0.1 mg oral ramosetron (PO), or 0.3 mg IV ramosetron (IV). Total intravenous anesthesia (TIVA) with propofol and remifentanil was used in all patients.

Results

The incidence of complete response (no PONV, no rescue) in the control, IV, and PO groups was: 65%, 90%, and 87.5%, respectively, during the first 1 h; and 67.5%, 87.5%, and 80%, respectively, during 1 to 24 h.

Conclusion

The effect of oral ramosetron 0.1 mg was comparable to that of IV ramosetron 0.3 mg on the prevention of PONV in women undergoing gynecological laparoscopy with TIVA. Both the oral and IV forms were effective at preventing PONV during the first 1 h after surgery.

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Authors and Affiliations

  1. Department of Anesthesiology and Pain Medicine, Gil Medical Center, Gachon University of Medicine and Science, 1198 Guwol-dong, Namdong-gu, Incheon, 405-760, Korea

    Dongchul Lee, Yeon Soo Park & Hyun Jeong Kwak

  2. Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea

    Ji Young Kim

  3. Department of Obstetrics and Gynecology, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea

    Jin Woo Shin & Chun Hoe Ku

Authors
  1. Dongchul Lee
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  2. Ji Young Kim
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  3. Jin Woo Shin
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  4. Chun Hoe Ku
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  5. Yeon Soo Park
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  6. Hyun Jeong Kwak
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Lee, D., Kim, J.Y., Shin, J.W. et al. The effect of oral and IV ramosetron on postoperative nausea and vomiting in patients undergoing gynecological laparoscopy with total intravenous anesthesia. J Anesth 23, 46–50 (2009). https://doi.org/10.1007/s00540-008-0693-4

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  • DOI: https://doi.org/10.1007/s00540-008-0693-4

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