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The prognostic impact of bowel perforation following self-expanding metal stent as a bridge to surgery in colorectal cancer obstruction

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Abstract

Background

Self-expanding metallic stent (SEMS) as a bridge to surgery for obstructive colorectal cancer may cause perforation of the tumor and thereby induce tumor spread and increase risk of recurrence, and eventually death. Evidence of the prognostic impact of SEMS-related perforation is, however, sparse. We conducted a long-term follow-up study to compare characteristics, overall survival, and recurrence rates between patients with and without SEMS-related bowel perforation.

Method

This long-term follow-up study included obstructive colorectal cancer patients treated with SEMS as a bridge to surgery during a 10-year period at two primary and tertiary referral centers. The primary outcome was overall survival, and the secondary outcome was recurrence. We compared mortality and recurrence in patients with and without SEMS-related perforations by Cox proportion hazard regression, adjusting for age, comorbidity, and disease stage. The recurrence risk was examined for patients undergoing curative resection and computed treating death as a competing risk.

Results

From January 2004 to December 2013, 123 patients were treated with SEMS as a bridge to surgery. Of these patients, 15 (12%) had SEMS-related perforations. Median follow-up was 4.8 years (range 0.0–10.9 years). The overall 5-year survival was 58% for the entire cohort, but 37 and 61% for patients with and without perforations, respectively, corresponding to an adjusted hazard ratio of 1.6 (95% CI 0.8–3.3) in favor of patient without perforation. The overall 5-year recurrence rate was 34%, but 45 and 33% for patients with and without perforation, respectively, corresponding to an adjusted hazard ratio of 1.4 (95% CI 0.5–3.7) in disfavor of patients with perforation.

Conclusion

SEMS-related perforations are common and may be associated with decreased survival and increased recurrence, although estimates in this study were imprecise.

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Authors and Affiliations

  1. Department of Surgery, Section of Coloproctology, Aarhus University Hospital, Tage-Hansens Gade 2, 8000, Aarhus, Denmark

    Tue Højslev Avlund, Rune Erichsen, Sissel Ravn, Søren Laurberg & Lene H. Iversen

  2. Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark

    Rune Erichsen

  3. Department of Surgery A, Aalborg University Hospital, Aalborg, Denmark

    Zydrunas Ciplys & Jens Christian Andersen

Authors
  1. Tue Højslev Avlund
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  2. Rune Erichsen
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  3. Sissel Ravn
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  4. Zydrunas Ciplys
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  5. Jens Christian Andersen
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  6. Søren Laurberg
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  7. Lene H. Iversen
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Correspondence to Tue Højslev Avlund.

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Disclosure

Tue Højslev Avlund, Rune Erichsen, Sissel Ravn, Zydrunas Ciplys, Jens Christian Andersen, Søren Laurberg, and Lene H. Iversen have no conflicts of interest or financial ties to disclose.

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Avlund, T.H., Erichsen, R., Ravn, S. et al. The prognostic impact of bowel perforation following self-expanding metal stent as a bridge to surgery in colorectal cancer obstruction. Surg Endosc 32, 328–336 (2018). https://doi.org/10.1007/s00464-017-5680-0

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  • DOI: https://doi.org/10.1007/s00464-017-5680-0

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