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Prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status

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Abstract

Vitamin D deficiency is common in Southeast Asia but there are limited data in pregnant women and neonates. This study aimed to determine the prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status. A total of 94 pregnant women and their neonates were included. Clinical data and venous maternal blood for calcium, phosphate, albumin, alkaline phosphatase, magnesium, intact parathyroid hormone (iPTH), and vitamin D (25OHD) were obtained on the day of labor. Cord blood was collected following delivery to evaluate vitamin D status of newborns. Mean serum maternal and cord blood 25OHD levels were 25.42 ± 8.07 and 14.85 ± 5.13 ng/mL. The prevalence of vitamin D deficiency (25OHD < 12 ng/mL) and insufficiency (25OHD 12–20 ng/mL) in cord blood of newborns were 20.2 and 69.1%, respectively. There was a significant correlation between maternal and cord blood vitamin D levels (r = 0.86; P < 0.001). The factors associated with cord blood vitamin D deficiency were low maternal 25OHD level and no vitamin D supplement during pregnancy.

Conclusion: There is a high prevalence of vitamin D deficiency among Thai neonates. Adequate prenatal vitamin D supplementation should be implemented as routine antenatal care.

What is Known:

• Vitamin D deficiency is prevalent in Southeast Asia.

• There are widespread vitamin D deficiency among Thai populations including pregnant women.

What is New:

• There is a high prevalence of vitamin D deficiency among Thai neonates.

• The factors associated with cord blood vitamin D deficiency are low maternal vitamin D level and no vitamin D supplement during pregnancy.

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Abbreviations

25OHD:

25-Hydroxyvitamin D

iPTH:

Intact parathyroid hormone

UVB:

Ultraviolet B

VDD:

Vitamin D deficiency

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Acknowledgments

We would like to thank the patients and their families for participation in this study and Dr. Somchit Jaruratanasirikul for her constructive comments on our work and her editing of the text.

Funding

This study was supported by the Panyananthaphikkhu Chonprathan Medical Center research funding.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University, Nonthaburi, 11120, Thailand

    Kansuda Ariyawatkul

  2. Department of Obstretrics and Gynecology, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University, Nonthaburi, 11120, Thailand

    Porntita Lersbuasin

Authors
  1. Kansuda Ariyawatkul
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  2. Porntita Lersbuasin
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Contributions

KA conceived of the study, participated in its design, analysis and interpretation of data, and drafted the manuscript. PL participated in the design of study, acquisition of data and coordination of the study. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Kansuda Ariyawatkul.

Ethics declarations

All procedures were performed according to the Declaration of Helsinki and approved by the Ethics Committee, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University. Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare that they have no conflict of interest and do not have a financial relationship with the organization that sponsored the research.

Disclosure statement

The authors have nothing to disclose.

Additional information

Communicated by Peter de Winter

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Ariyawatkul, K., Lersbuasin, P. Prevalence of vitamin D deficiency in cord blood of newborns and the association with maternal vitamin D status. Eur J Pediatr 177, 1541–1545 (2018). https://doi.org/10.1007/s00431-018-3210-2

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  • DOI: https://doi.org/10.1007/s00431-018-3210-2

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