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Nicolau syndrome induced by intramuscular vitamin K in a premature newborn

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Abstract

Introduction

Nicolau syndrome (NS), also known as livedo-like dermatitis or embolia cutis medicamentosa, is a very rare complication of intramuscular and intraarticular injection of various drugs.

Case report

We herein report a case of NS developing approximately 2 h after the intramuscular administration of vitamin K1 in an extremely low birth weight premature newborn. To our knowledge, this patient is the youngest case suffering from such a livedoid skin necrosis and the first case of neonatal NS developing due to intramuscular administration of vitamin K1.

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References

  1. Bourrat E, Moraillon I, Vignon-Pennamen MD et al (1996) Scleroderma-like patch on the thigh in infants after vitamin K injection at birth: six observations. Ann Dermatol Venereol 123:634–638

    CAS  PubMed  Google Scholar 

  2. Erkek E, Tuncez F, Sanli C et al (2006) Nicolau's syndrome in a newborn caused by triple DTP (diphtheria-tetanus-pertussis) vaccination. J Am Acad Dermatol 54:S241–S242. doi:10.1016/j.jaad.2005.09.046

    Article  PubMed  Google Scholar 

  3. Guidetti MS, Vincenzi C, Papi M, Tosti A (1994) Sclerodermatous skin reaction after vitamin K1 injections. Contact Dermatitis 31:45–46. doi:10.1111/j.1600-0536.1994.tb01905.x

    Article  CAS  PubMed  Google Scholar 

  4. Kienast AK, Mentze D, Hoeger PH (2008) Nicolau’s syndrome induced by intramuscular vaccinations in children: report of seven patients and review of the literature. Clin Exp Dermatol 33:555–558. doi:10.1111/j.1365-2230.2008.02861.x

    Article  CAS  PubMed  Google Scholar 

  5. Luton K, Garcia C, Poletti E, Koester G (2006) Nicolau Syndrome: three cases and review. Int J Dermatol 45:1326–1328. doi:10.1111/j.1365-4632.2006.02674.x

    Article  PubMed  Google Scholar 

  6. Wilkins K, DeKoven J, Assaad D (2000) Cutaneous reactions associated with vitamin K1. J Cutan Med Surg 4:164–168

    CAS  PubMed  Google Scholar 

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Miscellaneous

We (the authors) did not have any financial relationship with any organization; furthermore, there have been no organization that sponsored the research.

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Correspondence to Esad Koklu.

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Koklu, E., Sarici, S.U., Altun, D. et al. Nicolau syndrome induced by intramuscular vitamin K in a premature newborn. Eur J Pediatr 168, 1541–1542 (2009). https://doi.org/10.1007/s00431-009-0964-6

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  • DOI: https://doi.org/10.1007/s00431-009-0964-6

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