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Concurrent epithelioid hemangioma and diffuse cavernous hemangioma in the rectum clinically mimicking a malignant tumor: a case report

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Abstract

Epithelioid hemangioma is a rare benign vascular tumor that consists of capillary-sized vessels lined by epithelioid endothelial cells. Diffuse cavernous hemangioma is a congenital benign vascular neoplasm consisting of increased dilated vessels. We report a case of epithelioid hemangioma and diffuse cavernous hemangioma that co-occurred in the rectum. To our knowledge, this is the first report in which two rare vascular lesions coexisted. Because both epithelioid hemangioma and diffuse cavernous hemangioma are often clinically confounded by malignant tumors, differentiating these benign lesions from other possible malignant tumors is significant.

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Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

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Authors and Affiliations

  1. Department of Pathology, Graduate School of Medicine, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan

    Mariko Yasui, Yoshinao Kikuchi, Satoe Numakura, Shiori Watabe & Hiroshi Uozaki

  2. Department of Pathology, Teikyo University Hospital, Tokyo, Japan

    Mutsuo Fujikura

  3. Department of Pathology, Mitsui Memorial Hospital, Tokyo, Japan

    Shigeki Morita

  4. Department of Surgery, Graduate School of Medicine, Teikyo University, Tokyo, Japan

    Keijiro Nozawa, Keiji Matsuda & Yojiro Hashiguchi

  5. Department of Diagnostic Pathology, National Hospital Organization, Saitama Hospital, Saitama, Japan

    Tsuyoshi Ishida

Authors
  1. Mariko Yasui
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  2. Yoshinao Kikuchi
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  3. Mutsuo Fujikura
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  4. Shigeki Morita
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  5. Satoe Numakura
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  6. Shiori Watabe
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  7. Keijiro Nozawa
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  8. Keiji Matsuda
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  9. Yojiro Hashiguchi
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  10. Tsuyoshi Ishida
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  11. Hiroshi Uozaki
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Contributions

All authors contributed to the study conception and design. Material preparation and data collection and analysis were performed by Mariko Yasui, Yoshinao Kikuchi, Mutsuo Fujikura, Shigeki Morita, Shiori Watabe, and Tsuyoshi Ishida. Keijiro Nozawa, Keiji Matsuda, and Yojiro Hashiguchi gave the patient’s clinical information. The first draft of the manuscript was written by Mariko Yasui. Satoe Numakura and Hiroshi Uozaki commented on previous versions of the manuscript and provided a critical review. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Yoshinao Kikuchi.

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Written informed consent was obtained from the patient for publication of the case report.

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Written informed consent was obtained from the patient for publication of the case report.

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Written informed consent was obtained from the patient for publication of the case report.

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The authors declare no conflict of interest.

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This article is part of the Topical Collection on Quality in Pathology

Supplementary information

ESM 1

Immunohistochemical analysis for FOS-B. a Focal and weak FOS-B expression in the epithelioid hemangioma. Bar, 50 μm. b Focal and weak expression in the diffuse cavernous hemangioma. Bar, 50 μm. c Hematoxylin and eosin (H&E) staining of pseudomyogenic hemangioendothelioma as a positive control. Bar, 50 μm. d Diffuse and strong FOS-B expression in the pseudomyogenic hemangioendothelioma. Bar, 50 μm (PDF 979 kb)

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Yasui, M., Kikuchi, Y., Fujikura, M. et al. Concurrent epithelioid hemangioma and diffuse cavernous hemangioma in the rectum clinically mimicking a malignant tumor: a case report. Virchows Arch 479, 847–851 (2021). https://doi.org/10.1007/s00428-021-03035-3

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  • DOI: https://doi.org/10.1007/s00428-021-03035-3

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