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Chief cell proliferation of the gastric mucosa mimicking early gastric cancer: an unusual variant of fundic gland polyp

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Abstract

We describe a hitherto unknown lesion of gastric chief cell proliferation mimicking structurally mucosal gastric cancer. The unremarkable cytology of the cells, their very low Ki-67 index, the inclusion of occasional parietal cells and especially ultrastructural evidence of chief cell differentiation proved helpful in the differentiation from early gastric cancer. The exact classification of the alteration remains unresolved. The presence of microcysts suggests that the lesion is a variant of fundic gland polyp formation.

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Acknowledgements

The authors thanks Prof. M. Stolte, Institute of Pathology, Klinikum Bayreuth, for valuable comments. The authors are indebted to Ms. Brigitte Schult and Ms. Maria Wittmeier for carefully preparing the manuscript and to Ms. Sabine Schäfer for valuable technical assistance.

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Authors and Affiliations

  1. Pathologisches Institut, Ludwig-Maximilians-Universität, Thalkirchner Strasse 36, 80337, Munich, Germany

    J. Müller-Höcker

  2. Medizinische Klinik II, Klinikum Großhadern, Ludwig-Maximilians-Universität, Munich, Germany

    P. Rellecke

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  1. J. Müller-Höcker
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  2. P. Rellecke
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Correspondence to J. Müller-Höcker.

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Müller-Höcker, J., Rellecke, P. Chief cell proliferation of the gastric mucosa mimicking early gastric cancer: an unusual variant of fundic gland polyp. Virchows Arch 442, 496–500 (2003). https://doi.org/10.1007/s00428-003-0780-8

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  • DOI: https://doi.org/10.1007/s00428-003-0780-8

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