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An orphan PRD class homeobox gene expressed in mouse brain and limb development

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Abstract.

We report the cDNA sequence and expression of a mouse homeobox gene, Dmbx1, from the PRD class and comparison to its human orthologue. The gene defines a new homeobox gene family, Dmbx, phylogenetically distinct from the Ptx, Alx, Prx Otx, Gsc, Otp and Pax gene families. The Dmbx1 gene is expressed in the developing mouse diencephalon, midbrain and hindbrain, and has dynamic expression during forelimb and hindlimb development. Unusually for homeobox genes, there is no orthologue in the Drosophila or Caenorhabditis genomes; we argue this reflects secondary loss.

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Authors and Affiliations

  1. School of Animal and Microbial Science, The University of Reading, Whiteknights, Reading, RG6 6AJ, UK, , , , ,

    Tokiharu Takahashi, Peter W. Holland & Martin J. Cohn

  2. Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7–3-1 Hongo, Bunkyo-ku, Tokyo 113–8655, Japan, , , , ,

    Mineo Kurokawa

  3. Pharmaceutical Division, Pharmaceutical Research Laboratories, Kirin Brewery Co. Ltd., Miyahara 3 Takasaki, Gunma 370–1295, Japan, , , , ,

    Kiyoshi Shimizu

  4. Department of Cell Therapy and Transplantation Medicine, Graduate School of Medicine, University of Tokyo, 7–3-1 Hongo, Bunkyo-ku, Tokyo 113–8655, Japan, , , , ,

    Hisamaru Hirai

Authors
  1. Tokiharu Takahashi
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  2. Peter W. Holland
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  3. Martin J. Cohn
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  4. Kiyoshi Shimizu
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  5. Mineo Kurokawa
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  6. Hisamaru Hirai
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Takahashi, T., Holland, P.W., Cohn, M.J. et al. An orphan PRD class homeobox gene expressed in mouse brain and limb development. Dev Genes Evol 212, 293–297 (2002). https://doi.org/10.1007/s00427-002-0244-1

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  • DOI: https://doi.org/10.1007/s00427-002-0244-1

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