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The Movement Disorders Society criteria for the diagnosis of Parkinson’s disease dementia: their usefulness and limitations in elderly patients

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Abstract

The aim of this study was to assess the performance of the Movement Disorders Society (MDS) criteria for the diagnosis of Parkinson’s disease dementia (PDD) in the elderly, and also to evaluate the relevance of applying other tests in this patient population. The MDS criteria include a first short part in checklist form, and a second part which is used as a basis for reference and consists of an in-depth neuropsychological examination. Forty consecutive PD patients presenting with cognitive complaints were enrolled. An assessment was made of the performances of the MDS checklist compared with the MDS exhaustive cognitive examination which was used as a basis for reference, and with other cognitive tests including the Mattis Dementia Rating Scale (MDRS), the French version of the Grober and Buschke test, the verbal fluency test, the Rey–Osterreith complex figure and the paced auditory serial addition test. Out of a total of 40 PD subjects (mean age: 80.5 ± 4.9 years), 20 were diagnosed with PDD according to the checklist and 31 on the basis of the exhaustive examination, i.e. with 11 more patients diagnosed via the latter. The sensitivity of the checklist for the diagnosis of PDD was 0.64, with a specificity of 1.00. The use of the MDRS for PDD diagnosis with a cut-off at ≤120 showed a sensitivity of 0.80 and a specificity of 1.00, while at ≤132 it displayed a sensitivity of 1.00 and a specificity of 0.444. The specificity of the checklist for the diagnosis of PDD in the elderly was confirmed, but it was lacking in sensitivity. It was also found that the MDRS could be helpful in the diagnosis and screening of PDD.

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Acknowledgments

We would like to thank Marilyn Schreier-Audoire for her assistance in translating and copy-editing this article.

Conflicts of interest

On behalf of all the authors, the corresponding author states that there is no conflict of interest to report.

Ethical standard

This study was approved by the ethics committee of Strasbourg University Hospital and was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Authors and Affiliations

  1. Department of Geriatrics, Robertsau Hospital, Strasbourg University Hospitals, 83 rue Himmerich, Strasbourg, 67091, France

    Michèle Kiesmann, Thomas Vogel, Laetitia Schweiger & Georges Kaltenbach

  2. Department of Neurology, Hautepierre Hospital, Strasbourg University Hospitals, Strasbourg, France

    Jean-Baptiste Chanson

  3. Department of Public Health, Biostatistics and Methodology Sector, Strasbourg University Hospitals, Strasbourg, France

    Julien Godet

  4. Department of Clinical Research, Civil Hospital, Strasbourg University Hospitals, Strasbourg, France

    Saïd Chayer

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  1. Michèle Kiesmann
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  4. Thomas Vogel
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  7. Georges Kaltenbach
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Correspondence to Michèle Kiesmann.

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Kiesmann, M., Chanson, JB., Godet, J. et al. The Movement Disorders Society criteria for the diagnosis of Parkinson’s disease dementia: their usefulness and limitations in elderly patients. J Neurol 260, 2569–2579 (2013). https://doi.org/10.1007/s00415-013-7018-8

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  • DOI: https://doi.org/10.1007/s00415-013-7018-8

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