Skip to main content

Advertisement

Log in

DSM-5 reviewed from different angles: goal attainment, rationality, use of evidence, consequences—part 1: general aspects and paradigmatic discussion of depressive disorders

  • Original Paper
  • Published:
European Archives of Psychiatry and Clinical Neuroscience Aims and scope Submit manuscript

Abstract

DSM-5 was published in 2013 after about 10 years of preparation. Part 1 of this paper discusses several more general aspects of DSM-5 and offers a detailed, paradigmatic analysis of changes made to the chapter on depressive disorders. The background for the changes is analysed on the basis of a PubMed search and review papers on the classification of mental disorders in general and on empirical knowledge about individual disorders. Contrary to the original plans, DSM-5 has not introduced a primarily dimensional diagnostic system but has widely preserved the categorical system of disorders. Also, it has not adopted a more neurobiological approach to disorders by including biological markers to increase the objectivity of psychiatric diagnoses but has maintained the primarily symptom-based, descriptive approach. The criteria for some disorders have been changed, including affective, schizophrenic and addiction disorders, and a few new disorders have been added. A minimal version of the dimensional approach was realised through the introduction of several transnosological specifiers and the option to make symptom- or syndrome-related severity and dimensional assessments. These specifiers and assessments might allow a more individualised description of a patient’s psychopathological state and more personalised treatment. However, most of the symptom- and syndrome-related assessments are not mandatory and therefore may not be used in clinical practice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Akiskal HS, Benazzi F, Perugi G, Rihmer Z (2005) Agitated “unipolar” depression re-conceptualized as a depressive mixed state: implications for the antidepressant-suicide controversy. J Affect Disord 85:245–258

    Article  PubMed  Google Scholar 

  2. American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Arlington

    Book  Google Scholar 

  3. Andrews G, Brugha T, Thase ME, Duffy FF, Rucci P, Slade T (2007) Dimensionality and the category of major depressive episode. Int J Methods Psychiatr Res 16(Suppl 1):S41–S51

    Article  PubMed  Google Scholar 

  4. Angst J, Azorin JM, Bowden CL, Perugi G, Vieta E, Gamma A, Young AH (2011) Prevalence and characteristics of undiagnosed bipolar disorders in patients with a major depressive episode: the BRIDGE study. Arch Gen Psychiatry 68:791–798

    Article  PubMed  Google Scholar 

  5. Angst J, Cui L, Swendsen J, Rothen S, Cravchik A, Kessler RC, Merikangas KR (2010) Major depressive disorder with subthreshold bipolarity in the national comorbidity survey replication. Am J Psychiatry 167:1194–1201

    Article  PubMed Central  PubMed  Google Scholar 

  6. Angst J, Gamma A, Benazzi F, Ajdacic V, Eich D, Rossler W (2003) Toward a re-definition of subthreshold bipolarity: epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania. J Affect Disord 73:133–146

    Article  PubMed  Google Scholar 

  7. Axelson D, Findling RL, Fristad MA, Kowatch RA, Youngstrom EA, Horwitz SM, Arnold LE, Frazier TW, Ryan N, Demeter C, Gill MK, Hauser-Harrington JC, Depew J, Kennedy SM, Gron BA et al (2012) Examining the proposed disruptive mood dysregulation disorder diagnosis in children in the longitudinal assessment of manic symptoms study. J Clin Psychiatry 73:1342–1350

    Article  PubMed Central  PubMed  Google Scholar 

  8. Baldessarini RJ, Faedda GL, Offidani E, Vazquez GH, Marangoni C, Serra G, Tondo L (2013) Antidepressant-associated mood-switching and transition from unipolar major depression to bipolar disorder: a review. J Affect Disord 148:129–135

    Article  CAS  PubMed  Google Scholar 

  9. Berk M (2013) The DSM-5: hyperbole, hope or hypothesis? BMC Med 11:128

    Article  PubMed Central  PubMed  Google Scholar 

  10. Blennow K, Hampel H, Weiner M, Zetterberg H (2010) Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat Rev Neurol 6:131–144

    Article  CAS  PubMed  Google Scholar 

  11. Brown TA, Di Nardo PA, Lehman CL, Campbell LA (2001) Reliability of DSM-IV anxiety and mood disorders: implications for the classification of emotional disorders. J Abnorm Psychol 110:49–58

    Article  CAS  PubMed  Google Scholar 

  12. Carroll BJ (2013) Biomarkers in DSM-5: lost in translation. Aust N Z J Psychiatry 47:676–678

    Article  PubMed  Google Scholar 

  13. Carroll BJ (2012) Bringing back melancholia. Bipolar Disord 14:1–5

    Article  PubMed  Google Scholar 

  14. Clarke DE, Narrow WE, Regier DA, Kuramoto SJ, Kupfer DJ, Kuhl EA, Greiner L, Kraemer HC (2013) DSM-5 field trials in the United States and Canada, part I: study design, sampling strategy, implementation, and analytic approaches. Am J Psychiatry 170:43–58

    Article  PubMed  Google Scholar 

  15. Copeland WE, Angold A, Costello EJ, Egger H (2013) Prevalence, comorbidity, and correlates of DSM-5 proposed disruptive mood dysregulation disorder. Am J Psychiatry 170:173–179

    Article  PubMed Central  PubMed  Google Scholar 

  16. Copeland WE, Shanahan L, Egger H, Angold A, Costello EJ (2014) Adult diagnostic and functional outcomes of DSM-5 disruptive mood dysregulation disorder. Am J Psychiatry 171:668–674

    Article  PubMed  Google Scholar 

  17. Coryell W, Fiedorowicz JG, Solomon D, Leon AC, Rice JP, Keller MB (2012) Effects of anxiety on the long-term course of depressive disorders. Br J Psychiatry 200:210–215

    Article  PubMed Central  PubMed  Google Scholar 

  18. Cuthbert BN (2014) The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology. World Psychiatry 13:28–35

    Article  PubMed Central  PubMed  Google Scholar 

  19. Cuthbert BN, Insel TR (2013) Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Med 11:126

    Article  PubMed Central  PubMed  Google Scholar 

  20. Dimsdale JE (2013) Somatic symptom disorders: a new approach in DSM-5. Die Psychiatrie 10:30–32

    Google Scholar 

  21. Dunner DL (2003) Clinical consequences of under-recognized bipolar spectrum disorder. Bipolar Disord 5:456–463

    Article  PubMed  Google Scholar 

  22. Egli S, Riedel M, Moller HJ, Strauss A, Lage D (2009) Creating a map of psychiatric patients based on psychopathological symptom profiles. Eur Arch Psychiatry Clin Neurosci 259:164–171

    Article  PubMed  Google Scholar 

  23. Epperson CN, Steiner M, Hartlage SA, Eriksson E, Schmidt PJ, Jones I, Yonkers KA (2012) Premenstrual dysphoric disorder: evidence for a new category for DSM-5. Am J Psychiatry 169:465–475

    Article  PubMed Central  PubMed  Google Scholar 

  24. Ewers M, Sperling RA, Klunk WE, Weiner MW, Hampel H (2011) Neuroimaging markers for the prediction and early diagnosis of Alzheimer’s disease dementia. Trends Neurosci 34:430–442

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  25. Fawcett J (2010) An overview of mood disorders in the DSM-5. Curr Psychiatry Rep 12:531–538

    Article  PubMed  Google Scholar 

  26. First MB (2014) Preserving the clinician–researcher interface in the age of RDoC: the continuing need for DSM-5/ICD-11 characterization of study populations. World Psychiatry 13:53–54

    Article  PubMed Central  PubMed  Google Scholar 

  27. Flint J, Kendler KS (2014) The genetics of major depression. Neuron 81:484–503

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  28. Goldberg D (2008) Towards DSM-V: the relationship between generalized anxiety disorder and major depressive episode. Psychol Med 38:1671–1675

    Article  CAS  PubMed  Google Scholar 

  29. Goldberg DP (2010) Diagnostic issues in depression and generalized anxiety disorder. Refining the research agenda for DSM-V. American Psychiatric Association, Arlington

    Google Scholar 

  30. Goldberg DP, Wittchen HU, Beesdo-Baum K, Zimmermann P, Pfister H (2013) Anxious and non-anxious forms of major depression: familial, personality and symptom characteristics. Psychol Med 1–12

  31. Hampel H, Frank R, Broich K, Teipel SJ, Katz RG, Hardy J, Herholz K, Bokde AL, Jessen F, Hoessler YC, Sanhai WR, Zetterberg H, Woodcock J, Blennow K (2010) Biomarkers for Alzheimer’s disease: academic, industry and regulatory perspectives. Nat Rev Drug Discov 9:560–574

    Article  CAS  PubMed  Google Scholar 

  32. Hartlage SA, Breaux CA, Yonkers KA (2014) Addressing concerns about the inclusion of premenstrual dysphoric disorder in DSM-5. J Clin Psychiatry 75:70–76

    Article  PubMed  Google Scholar 

  33. Hollander E (2011) Obsessive–compulsive spectrum disorders: refining the research agenda for DSM-V. American Psychiatric Association, Arlington

    Google Scholar 

  34. Hyman SE (2008) Can neuroscience be integrated into the DSM-V? Nat Rev Neurosci 8:725–732

    Article  Google Scholar 

  35. Insel T (2013) Director’s Blog: Transforming Diagnosis. National Institute of Mental Health. http://www.nimh.nih.gov/about/director/2013/transforming-diagnosis.shtml. Accessed 13 Dec 2013

  36. Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS, Quinn K, Sanislow C, Wang P (2010) Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry 167:748–751

    Article  PubMed  Google Scholar 

  37. Kendler K (2008) Book review: the loss of sadness: how psychiatry transformed normal sorrow into depressive disorder, by Horwitz AB, Wakefield JC. Psychol Med 39:1935–1941

    Article  Google Scholar 

  38. Kendler KS (2009) An historical framework for psychiatric nosology. Psychol Med 39:1935–1941

    Article  PubMed Central  PubMed  Google Scholar 

  39. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ (1992) Major depression and generalized anxiety disorder. Same genes, (partly) different environments? Arch Gen Psychiatry 49:716–722

    Article  CAS  PubMed  Google Scholar 

  40. Kleinman A (2012) Culture, bereavement, and psychiatry. Lancet 379:608–609

    Article  PubMed  Google Scholar 

  41. Koutsouleris N, Borgwardt S, Meisenzahl EM, Bottlender R, Moller HJ, Riecher-Rossler A (2012) Disease prediction in the at-risk mental state for psychosis using neuroanatomical biomarkers: results from the FePsy study. Schizophr Bull 38:1234–1246

    Article  PubMed Central  PubMed  Google Scholar 

  42. Koutsouleris N, Davatzikos C, Borgwardt S, Gaser C, Bottlender R, Frodl T, Falkai P, Riecher-Rossler A, Moller HJ, Reiser M, Pantelis C, Meisenzahl E (2013) Accelerated brain aging in schizophrenia and beyond: a neuroanatomical marker of psychiatric disorders. Schizophr Bull. doi:10.1093/schbul/sbt142

    PubMed Central  Google Scholar 

  43. Kupfer DJ, Frank E, Phillips ML (2012) Major depressive disorder: new clinical, neurobiological, and treatment perspectives. Lancet 379:1045–1055

    Article  PubMed Central  PubMed  Google Scholar 

  44. Kupfer DJ, Regier DA (2011) Neuroscience, clinical evidence, and the future of psychiatric classification in DSM-5. Am J Psychiatry 168:672–674

    Article  PubMed  Google Scholar 

  45. Lage D, Egli S, Riedel M, Moller HJ (2012) Exploring the structure of psychopathological symptoms: a re-analysis of AMDP data by robust nonmetric multidimensional scaling. Eur Arch Psychiatry Clin Neurosci 262:227–238

    Article  PubMed  Google Scholar 

  46. Lage D, Egli S, Riedel M, Strauss A, Moller HJ (2011) Combining the categorical and the dimensional perspective in a diagnostic map of psychotic disorders. Eur Arch Psychiatry Clin Neurosci 261:3–10

    Article  PubMed  Google Scholar 

  47. Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA et al (2013) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 45:984–994

    Article  CAS  PubMed  Google Scholar 

  48. Leibenluft E (2011) Severe mood dysregulation, irritability, and the diagnostic boundaries of bipolar disorder in youths. Am J Psychiatry 168:129–142

    Article  PubMed Central  PubMed  Google Scholar 

  49. Maier W, Zobel A, Wagner M (2006) Schizophrenia and bipolar disorder: differences and overlaps. Curr Opin Psychiatry 19:165–170

    Article  PubMed  Google Scholar 

  50. Maj M (2012) Bereavement-related depression in the DSM-5 and ICD-11. World Psychiatry 11:1–2

    Article  PubMed Central  PubMed  Google Scholar 

  51. Maj M (2013) “Clinical judgment” and the DSM-5 diagnosis of major depression. World Psychiatry 12:89–91

    Article  PubMed Central  PubMed  Google Scholar 

  52. Maj M (2013) Mood disorders in ICD-11 and DSM-5. Die Psychiatrie 10:24–29

    Google Scholar 

  53. Maj M, Pirozzi R, Magliano L, Fiorillo A, Bartoli L (2007) Phenomenology and prognostic significance of delusions in major depressive disorder: a 10-year prospective follow-up study. J Clin Psychiatry 68:1411–1417

    Article  PubMed  Google Scholar 

  54. Malhi GS (2013) Diagnosis of bipolar disorder: who is in a mixed state? Lancet 381:1599–1600

    Article  PubMed  Google Scholar 

  55. Moller HJ (in press) The consequences of DSM-5 for psychiatric diagnosis and psychopharmacotherapy. Int J Psychiatry Clin Pract

  56. Moller HJ (2009) Development of DSM-V and ICD-11: tendencies and potential of new classifications in psychiatry at the current state of knowledge. Psychiatry Clin Neurosci 63:595–612

    Article  PubMed  Google Scholar 

  57. Moller HJ (in press) Dichotomy versus spectrum concept in approaching psychotic disorders: are we ready to make the final decision?. In: Soldatos C, Ruiz P, Dikeos D, Riba M (eds) Proceedings of the WPA thematic conference on intersectional collaboration 4th European congress of INA and the 1st interdisciplinary congress of HSAPRS, Athens, Greece, Nov 29 to Dec 2, 2012. Medimond s.r.l., Pianoro, Italy

  58. Moller HJ (2008) The forthcoming revision of the diagnostic and classificatory system: perspectives based on the European psychiatric tradition. Eur Arch Psychiatry Clin Neurosci 258(Suppl 5):7–17

    Article  PubMed  Google Scholar 

  59. Moller HJ (2008) Is there a need for a new psychiatric classification at the current state of knowledge? World J Biol Psychiatry 9:82–85

    Article  PubMed  Google Scholar 

  60. Moller HJ (2005) Problems associated with the classification and diagnosis of psychiatric disorders. World J Biol Psychiatry 6:45–56

    Article  PubMed  Google Scholar 

  61. Moller HJ (2009) Standardised rating scales in psychiatry: methodological basis, their possibilities and limitations and descriptions of important rating scales. World J Biol Psychiatry 10:6–26

    Article  PubMed  Google Scholar 

  62. Moller HJ (2008) Systematic of psychiatric disorders between categorical and dimensional approaches: Kraepelin’s dichotomy and beyond. Eur Arch Psychiatry Clin Neurosci 258(Suppl 2):48–73

    Article  PubMed  Google Scholar 

  63. Moller HJ, Jager M, Riedel M, Obermeier M, Strauss A, Bottlender R (2011) The Munich 15-year follow-up study (MUFUSSAD) on first-hospitalized patients with schizophrenic or affective disorders: assessing courses, types and time stability of diagnostic classification. Eur Psychiatry 26:231–243

    Article  CAS  PubMed  Google Scholar 

  64. Narrow WE, Clarke DE, Kuramoto SJ, Kraemer HC, Kupfer DJ, Greiner L, Regier DA (2013) DSM-5 field trials in the United States and Canada, part III: development and reliability testing of a cross-cutting symptom assessment for DSM-5. Am J Psychiatry 170:71–82

    Article  PubMed  Google Scholar 

  65. Papakostas GI, Shelton RC, Kinrys G, Henry ME, Bakow BR, Lipkin SH, Pi B, Thurmond L, Bilello JA (2013) Assessment of a multi-assay, serum-based biological diagnostic test for major depressive disorder: a pilot and replication study. Mol Psychiatry 18:332–339

    Article  CAS  PubMed  Google Scholar 

  66. Patkar A, Gilmer W, Pae CU, Vohringer PA, Ziffra M, Pirok E, Mulligan M, Filkowski MM, Whitham EA, Holtzman NS, Thommi SB, Logvinenko T, Loebel A, Masand P, Ghaemi SN (2012) A 6 week randomized double-blind placebo-controlled trial of ziprasidone for the acute depressive mixed state. PLoS One 7:e34757

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  67. Perlis RH, Cusin C, Fava M (2012) Proposed DSM-5 mixed features are associated with greater likelihood of remission in out-patients with major depressive disorder. Psychol Med 1–7

  68. Phillips KA, Stein DJ, Rauch SL, Hollander E, Fallon BA, Barsky A, Fineberg N, Mataix-Cols D, Ferrao YA, Saxena S, Wilhelm S, Kelly MM, Clark LA, Pinto A, Bienvenu OJ et al (2010) Should an obsessive-compulsive spectrum grouping of disorders be included in DSM-V? Depress Anxiety 27:528–555

    Article  PubMed Central  PubMed  Google Scholar 

  69. Phillips ML, Kupfer DJ (2013) Bipolar disorder diagnosis: challenges and future directions. Lancet 381:1663–1671

    Article  PubMed  Google Scholar 

  70. Regier DA, Kuhl EA, Kupfer DJ (2013) The DSM-5: classification and criteria changes. World Psychiatry 12:92–98

    Article  PubMed Central  PubMed  Google Scholar 

  71. Regier DA, Narrow WE, Clarke DE, Kraemer HC, Kuramoto SJ, Kuhl EA, Kupfer DJ (2013) DSM-5 field trials in the United States and Canada, part II: test–retest reliability of selected categorical diagnoses. Am J Psychiatry 170:59–70

    Article  PubMed  Google Scholar 

  72. Seemuller F, Riedel M, Obermeier M, Schennach-Wolff R, Spellmann I, Meyer S, Bauer M, Adli M, Kronmuller K, Ising M, Brieger P, Laux G, Bender W, Heuser I, Zeiler J et al (2012) The validity of self-rated psychotic symptoms in depressed in patients. Eur Psychiatry 27:547–552

    Article  CAS  PubMed  Google Scholar 

  73. Sparks GM, Axelson DA, Yu H, Ha W, Ballester J, Diler RS, Goldstein B, Goldstein T, Hickey MB, Ladouceur CD, Monk K, Sakolsky D, Birmaher B (2014) Disruptive mood dysregulation disorder and chronic irritability in youth at familial risk for bipolar disorder. J Am Acad Child Adolesc Psychiatry 53:408–416

    Article  PubMed  Google Scholar 

  74. Stahl SM (2013) The last diagnostic and statistical manual (DSM): replacing our symptom-based diagnoses with a brain circuit-based classification of mental illnesses. CNS Spectr 18:65–68

    Article  PubMed  Google Scholar 

  75. Starcevic V, Portman ME (2013) The status quo as a good outcome: how the DSM-5 diagnostic criteria for generalized anxiety disorder remained unchanged from the DSM-IV criteria. Aust N Z J Psychiatry 47:995–997

    Article  PubMed  Google Scholar 

  76. Steinmeyer EM, Klosterkotter J, Moller HJ, Sass H, Herpertz S, Czernik A, Marcea JT, Matakas F, Mehne J, Bottlander H, Hesse W, Steinbring I, Pukrop R (2002) Personality and personality disorders I. Universality and sensitivity of dimensional personality models as diagnostic systems for personality disorders. Fortschr Neurol Psychiatr 70:630–640

    Article  CAS  PubMed  Google Scholar 

  77. Steinmeyer EM, Klosterkotter J, Moller HJ, Sass H, Herpertz S, Czernik A, Marcea JT, Matakas F, Mehne J, Bottlander H, Hesse W, Steinbring I, Pukrop R (2002) Personality and personality disorders II. The Specificity of the DAPP-model as a diagnostic system for personality disorders. Fortschr Neurol Psychiatr 70:641–646

    Article  CAS  PubMed  Google Scholar 

  78. Stringaris A, Cohen P, Pine DS, Leibenluft E (2009) Adult outcomes of youth irritability: a 20-year prospective community-based study. Am J Psychiatry 166:1048–1054

    Article  PubMed Central  PubMed  Google Scholar 

  79. Sunderland T, Association American Psychiatric (2007) Diagnostic issues in dementia: advancing the research agenda for DSM-V. American Psychiatric Association, Arlington

    Google Scholar 

  80. Tamminga CA (2010) Deconstructing psychosis: refining the research agenda for DSM-V. American Psychiatric Association, Arlington

    Google Scholar 

  81. Tohen M, Strakowski SM, Zarate C Jr, Hennen J, Stoll AL, Suppes T, Faedda GL, Cohen BM, Gebre-Medhin P, Baldessarini RJ (2000) The McLean-Harvard first-episode project: 6-month symptomatic and functional outcome in affective and nonaffective psychosis. Biol Psychiatry 48:467–476

    Article  CAS  PubMed  Google Scholar 

  82. Trivedi MH, Rush AJ, Wisniewski SR, Nierenberg AA, Warden D, Ritz L, Norquist G, Howland RH, Lebowitz B, McGrath PJ, Shores-Wilson K, Biggs MM, Balasubramani GK, Fava M (2006) Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatry 163:28–40

    Article  PubMed  Google Scholar 

  83. Uher R, Farmer A, Maier W, Rietschel M, Hauser J, Marusic A, Mors O, Elkin A, Williamson RJ, Schmael C, Henigsberg N, Perez J, Mendlewicz J, Janzing JG, Zobel A et al (2008) Measuring depression: comparison and integration of three scales in the GENDEP study. Psychol Med 38:289–300

    CAS  PubMed  Google Scholar 

  84. Uher R, Payne JL, Pavlova B, Perlis RH (2013) Major depressive disorder in DSM-5: implications for clinical practice and research of changes from DSM-IV. Depress Anxiety

  85. van Os J, Delespaul P, Wigman J, Myin-Germeys I, Wichers M (2013) Beyond DSM and ICD: introducing “precision diagnosis” for psychiatry using momentary assessment technology. World Psychiatry 12:113–117

    Article  PubMed Central  PubMed  Google Scholar 

  86. Vieta E, Valenti M (2013) Mixed states in DSM-5: implications for clinical care, education, and research. J Affect Disord 148:28–36

    Article  PubMed  Google Scholar 

  87. World Health Organization (2010) International Classification of Diseases, 10th Revision (ICD-10). In: World Health Organization, Geneva

  88. Zielasek J, Gaebel W (2008) Modern modularity and the road towards a modular psychiatry. Eur Arch Psychiatry Clin Neurosci 258(Suppl 5):60–65

    Article  PubMed  Google Scholar 

  89. Zimmermann P, Bruckl T, Nocon A, Pfister H, Lieb R, Wittchen HU, Holsboer F, Angst J (2009) Heterogeneity of DSM-IV major depressive disorder as a consequence of subthreshold bipolarity. Arch Gen Psychiatry 66:1341–1352

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The authors thank Jacquie Klesing, Board-certified Editor in the Life Sciences (ELS), for editing assistance with the manuscript.

Conflict of interest

H.H. is supported by the AXA Research Fund (AXA RF) and the Fondation pour la Recherche sur Alzheimer (FRA), Paris, France. All other authors have no conflict of interest to declare.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hans-Jürgen Möller.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Möller, HJ., Bandelow, B., Bauer, M. et al. DSM-5 reviewed from different angles: goal attainment, rationality, use of evidence, consequences—part 1: general aspects and paradigmatic discussion of depressive disorders. Eur Arch Psychiatry Clin Neurosci 265, 5–18 (2015). https://doi.org/10.1007/s00406-014-0520-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00406-014-0520-x

Keywords

Navigation