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Experimental research on the therapeutic effect of MMR vaccine to juvenile-onset recurrent respiratory papillomatosis

  • Laryngology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Objective

To evaluate the efficacy of MMR vaccine in the treatment of juvenile-onset recurrent respiratory papillomatosis as adjuvant therapy by experimental research.

Methods

Thirty-one children with RRP were enrolled and assigned randomly to intervention group or control group. Fifteen subjects in intervention group were treated with local application MMR vaccine on the lesion after surgery; sixteen subjects in the control group were treated with surgical excision alone. The quantity of virus of positive specimens was measured by fluorescence quantitative polymerase chain reaction.

Results

After treatment with MMR vaccine, viral load of intervention group was (9.56 ± 11.03) × 108  copies/ml, that of control group was (22.01 ± 17.78) × 108 copies/ml, and there was significant difference between the two groups (P = 0.040).

Conclusions

Local application MMR vaccine as adjuvant therapy can reduce HPV viral load significantly. It is suggested that the MMR vaccine may inhibit replication of HPV DNA, but the curative effect needs further confirmation.

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Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 665000, China

    Yu Wang

  2. Research Center, Eye and ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China

    Pei-Dong Dai

  3. Department of Otorhinolaryngology, Eye and ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China

    Tian-Yu Zhang

Authors
  1. Yu Wang
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  2. Pei-Dong Dai
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  3. Tian-Yu Zhang
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Corresponding author

Correspondence to Yu Wang.

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Ethical approval

This study was approved by the Ethics Committee of EYE & ENT Hospital of Fudan University. Before entering the clinical trial, parents of these JORRP patients signed informed consent (see appendix for details at the end of the article) and volunteered to join the research. Therefore, the data and materials related to this study are available. There is no funding for this study, and there is no conflict of interest between researchers and between each researcher and institution. All the authors have no competing interests to declare. The study was registered in the Chinese Clinical Trial Registry. Details are as follows: Registration number: ChiCTR-TRC-11001370. Date of Registration: May 27, 2011 (Retrospective registration).

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Wang, Y., Dai, PD. & Zhang, TY. Experimental research on the therapeutic effect of MMR vaccine to juvenile-onset recurrent respiratory papillomatosis. Eur Arch Otorhinolaryngol 276, 801–803 (2019). https://doi.org/10.1007/s00405-019-05351-6

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  • DOI: https://doi.org/10.1007/s00405-019-05351-6

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