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Detection of cisplatin-induced ototoxicity with transient evoked otoacoustic emission test before pure tone audiometer

  • Otology
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Our aim was to investigate cisplatin ototoxicity with transient evoked otoacoustic emission (TEOAE) test before it is seen with pure tone audiometer. In our study, we compared the hearing of the patients who are receiving 100 mg/m2 4-cycle cisplatin for lung cancer, with pure tone audiometer and transient evoked otoacoustic emission test in 1,000, 2,000 and 4,000 Hz. We found 55% hearing decrease with pure tone audiometer in patients that are receiving 100 mg/m2 4-cycle cisplatin for lung cancer. We also established emission amplitude decrease with TEOAE test in 85% of the patients. When we compare the patients’ pure tone audiometer in 1,000, 2,000 and 4,000 Hz and TEOAE amplitude changes we did not find statistically significant results (P > 0.05), but when we compare the patients’ TEOAE amplitude changes in 1,000, 2,000 and 4,000 Hz with control group we found statistically significant results (P < 0.05). Our results show that cisplatin ototoxicity could be find out with TEOAE test before it is seen with pure tone audiometer.

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References

  1. Kemp DT (1978) Stimulated acoustic emissions from within the human auditory system. J Acoust Soc Am 64:1386–1391

    Article  CAS  PubMed  Google Scholar 

  2. Lopez Gonzales MA, Guerrero JM, Rojas F, Delgado F (2000) Ototoxicity caused by cisplatin is ameliorated by melatonin and other antioxidants. J Pineal Res 28:73–80

    Article  Google Scholar 

  3. Güneri EA, Şerbetçioğlu B, İkiz AÖ, Güneri A, Ceryan K (2001) TEOAE monitoring of cisplatin induced ototoxicity in guinea pigs: the protective effect of vitamin B treatment. Aur Nas Larynx 28:9–14

    Article  Google Scholar 

  4. Zhuravskii SG, Lopotko AI, Tomson VV, Ivanov AG, Chomskii AN, Nurskii KV (2002) Protective effect of calcium channel blocker verapamil on morphological and functional state of hair cells of the organ of corti in experimental kanamycin induced ototoxicity. Bull Exp Biol Med 133:466–469

    Article  Google Scholar 

  5. Merrin C (1978) Treatment of advanced bladder cancer with cisplatinum. J Urol 119:493–495

    CAS  PubMed  Google Scholar 

  6. Helson L, Okonkwo E, Anton L, Critkovic E (1978) Cisplatinum ototoxicity. Clin Toxicol 13:493–495

    Article  Google Scholar 

  7. Stadnicki SW, Fleishman RW, Schaeppi U et al (1975) Cisplatinum: hearing loss and other toxic effects in Rhesus monkeys. Cancer Chemother Rep 59:467–480

    PubMed  Google Scholar 

  8. Estrem SA, Babin RW, Ryan JH et al (1981) Cisplatinum ototoxicity in the guine pig. Otolaryngol Head Neck Surg 89:638–645

    CAS  PubMed  Google Scholar 

  9. Laurell G, Engström B (1989) The ototoxic effect of cisplatin on guinea pigs in relation to dosage. Hear Res 38:27–38

    Article  CAS  PubMed  Google Scholar 

  10. Fleishman RW, Stadnicki SW, Ethier ME, Schaeppi U (1975) Ototoxicity of cisplatinum in the guine pig. Toxicol Appl Pharmacol 33:320–332

    Article  Google Scholar 

  11. Anniko M, Sobin A (1986) Cisplatin: evaluation of its ototoxic potential. Am J Otorhinolaryngol 7:276–293

    CAS  Google Scholar 

  12. Aggarwal SK, Nioroomand-Rad I (1983) Effect of cisplatin on the plasma membrane phosphatase activities in ascites sarcoma-180 cells. J Histochem Cytochem 31:307–317

    CAS  PubMed  Google Scholar 

  13. Koch T, Gloddeck B (1991) İnhibition of the adenylate cyclase coupled G protein complex by ototoxic diuretics and cisplatinum in the inner ear of the guinea pig. Eur Arch Otorhinolaryngol 248:459–464

    Article  CAS  PubMed  Google Scholar 

  14. McAlpine D, Johnstone BM (1990) The ototoxic mechanism of cisplatin. Hear Res 47:191–204

    Article  CAS  PubMed  Google Scholar 

  15. Probst R (1990) Otoacoustic emissions: an overview. Adv Otolaryngol 44:1–91

    CAS  Google Scholar 

  16. Brown AM, McDowell B, Forge A (1989) Acoustic distortion products can be used to monitor the effects of chronic gentamicin treatment. Hear Res 42:143–156

    Article  CAS  PubMed  Google Scholar 

  17. Plinkert PK, Kröber S (1991) Früherkennung einer Cisplatin Ototoxizitat durch evozierte otoakustiche emissionen. Laryngorhinootologie 70:457–462

    Article  CAS  PubMed  Google Scholar 

  18. Beck A, Maurer J, Welkoborski H-J, Mann W (1992) Veraenderungen transitorisch evozierter otoakustischer Emissionen unter Chemotherapie mit Cisplatin und 5 FU. HNO 40:123–127

    CAS  PubMed  Google Scholar 

  19. Stavroulaki P, Apostolopoulos N, Dinopoulou D et al (1999) Otoacoustic emissions—an approach for monitoring aminoglycoside induced ototoxicity in children. İnt J Pediatr Otorhinolaryngol 50:177–184

    Article  CAS  PubMed  Google Scholar 

  20. Hotz MA, Harris FP, Probst R (1994) Otoacoustic emissions: an approach for monitoring aminoglycoside induced ototoxicity. Laryngoscope 104:1130–1134

    Article  CAS  PubMed  Google Scholar 

  21. Fausti SA, Henry JA, Schaffer HI, Olson DJ, Frey RH, Bagby GC (1993) High frequency monitoring for early detection of cisplatin ototoxicity. Arch Otolaryngol Head Neck Surg 119:661–666

    CAS  PubMed  Google Scholar 

  22. Biro K, Baki M, Büki B, Noszek L, Jokuti L (1997) Detection of early ototoxic effect in testicular cancer patients treated with cisplatin by transiently evoked otoacoustic emission: a pilot study. Oncology 54:387–390

    Article  CAS  PubMed  Google Scholar 

  23. Zorowka PG, Schmitt HJ, Gutjahr P (1993) Evoked otoacoustic emissions and pure tone threshold audiometry in patients receiving cisplatinum therapy. Int J Pediatr Otorhinolarngol 25:73–80

    Article  CAS  Google Scholar 

  24. Sockalingam R, Freeman S, Cherny L, Sohmer H (2000) Effect of high dose cisplatin on auditory brainstem responses and otoacoustic emissions in laboratory animals. Am J Otol 21:521–527

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of ENT and Head and Neck Surgery, Duzce Medical Faculty, Duzce University, Duzce, Turkey

    Süleyman Yılmaz

  2. Department of ENT and Head and Neck Surgery, Cerrahpaşa Medical Faculty, İstanbul University, Istanbul, Turkey

    Fatih Öktem & Emin Karaman

  3. Düzce Üniversitesi, Düzce Tıp Fak KBB ABD, Duzce, Turkey

    Süleyman Yılmaz

Authors
  1. Süleyman Yılmaz
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  2. Fatih Öktem
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  3. Emin Karaman
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Correspondence to Süleyman Yılmaz.

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Yılmaz, S., Öktem, F. & Karaman, E. Detection of cisplatin-induced ototoxicity with transient evoked otoacoustic emission test before pure tone audiometer. Eur Arch Otorhinolaryngol 267, 1041–1044 (2010). https://doi.org/10.1007/s00405-009-1165-7

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  • DOI: https://doi.org/10.1007/s00405-009-1165-7

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