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Incidence of virus infection as a cause of Meniere’s disease or endolymphatic hydrops assessed by electrocochleography

  • Neuro-Otology
  • Published:
European Archives of Oto-Rhino-Laryngology and Head & Neck Aims and scope Submit manuscript

Abstract

Meniere’s disease (MD) may follow viral infection such as by neurotropic viruses known to invade the endolymphatic sac (ES) and provoke endolymphatic hydrops (EH). The objective of this study was to investigate whether neurotropic viruses may cause infection of the inner ear and provoke EH. Antiviral immunoglobulin (IgG) assay against herpes simplex 1 (HSV1), herpes simplex 2 (HSV2), adenovirus (ADV), varicella zoster virus (VZV) and cytomegalovirus (CMV) were performed in 109 patients with an advanced stage of MD and compared with those obtained from 26 patients operated on because of vestibular schwannoma (VS), who served as a control group, to evaluate whether there is an association between the IgG levels and the ECoGs summating potential/action potential ratio (SP/AP ratio) in the MD group. In MD patients, the IgG titre against VZV and ADV were significantly higher than in the control (schwannoma) group. However, no correlation was found between the IgG levels against ADV and VZV with the SP/AP ratio. Neurotropic viruses such VZV and ADV may play a role in the pathogenesis of MD, despite the absence of association between the levels of IgG titres and the SP/AP ratio

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Authors and Affiliations

  1. Department of Otolaryngology, Central Hospital of Satakunta, Sairaalantie 3, 28130, Pori, Finland

    Ziane Selmani

  2. Department of Otolaryngology, Helsinki University Central Hospital, Helsinki, Finland

    Timo Marttila

  3. Department of Otolaryngology, Tampere University Hospital, Tampere, Finland

    Ilmari Pyykkö

Authors
  1. Ziane Selmani
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  2. Timo Marttila
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  3. Ilmari Pyykkö
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Correspondence to Ziane Selmani.

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Selmani, Z., Marttila, T. & Pyykkö, I. Incidence of virus infection as a cause of Meniere’s disease or endolymphatic hydrops assessed by electrocochleography. Eur Arch Otorhinolaryngol 262, 331–334 (2005). https://doi.org/10.1007/s00405-004-0816-y

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  • DOI: https://doi.org/10.1007/s00405-004-0816-y

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