Abstract
Purpose
To assess the effect of advanced maternal age on the obstetrics and neonatal outcome of twin pregnancies.
Methods
A retrospective study of 716 dichorionic–diamniotic twin pregnancies delivered at our institute. The study population was divided into two groups: women aged 35–39 years (group A, n = 142) and women aged ≥ 40 years (Group B, n = 48). The control group consisted of women younger than 35 years (group C, n = 516).
Results
The rate of cesarean section (CS) was significantly higher among women older than 35 years compared to the control group (A 76.8% and B 87.5% vs C 65.7%, P = 0.001). Women older than 35 years were also at higher risk for developing hypertensive disorders (A 7.0%, B 14.6%, vs C 5.4%, P = 0.04). On multivariate regression analysis, maternal age was found to be independently associated with a higher rate of CS (odds ratio vs reference group C: group A 1.6, 95% CI 1.08–2.6; group B 3.2, 95% CI 1.3–7.8). There was no difference between the groups in the rate of neonatal complications.
Conclusion
Women with twin pregnancy, older than 35 years, have a significantly higher rate of CS and hypertensive disorder. This rate increases with maternal age, with no increased rate of neonatal complications.
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OG: manuscript writing and project development. YM: data analysis and data collection. JB: data collection and project development. GB: project development and manuscript editing.
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Gluck, O., Mizrachi, Y., Bar, J. et al. The impact of advanced maternal age on the outcome of twin pregnancies. Arch Gynecol Obstet 297, 891–895 (2018). https://doi.org/10.1007/s00404-018-4656-1
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DOI: https://doi.org/10.1007/s00404-018-4656-1