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Anti-Mullerian hormone (AMH) and embryo quality assessed by time-lapse imaging (TLI): a cross-sectional observational study

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

Serum anti-Mullerian hormone shows a strong positive correlation to the quantitative ovarian reserve but its correlation to embryo quality is unclear. This study assessed the association between serum AMH as a marker of ovarian reserve and embryo quality, using the technology of time-lapse imaging of the embryos in women undergoing in vitro fertilisation (IVF) treatment.

Methods

304 embryos from 198 women undergoing IVF were included in the study. Serum AMH was assessed for all women. Embryo quality was assessed with the known implantation data (KID) score generated by the time-lapse imaging system.

Results

There was no statistically significant difference in mean serum AMH among different KID score categories (p = 0.135). This remained non-significant after controlling for confounding variables (p = 0.305).

Conclusions

The results of our study show no significant association between serum AMH and embryo quality in women undergoing IVF treatment when embryo quality was assessed using the KID scores generated by time-lapse imaging which is a better method of embryo assessment rather than conventional morphological assessment.

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Acknowledgements

The authors wish to thank the staff at the Homerton Fertility Centre for their assistance in screening and recruitment of participants for the study. No external funding was available for the study.

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Authors and Affiliations

  1. Homerton Fertility Centre, Homerton University Hospital NHS Foundation Trust, London, E9 6SR, UK

    P. Bhide, M. Escriba, A. Srikantharajah, H. Joshi, A. Gudi, A. Shah & R. Homburg

  2. Women’s Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsö, Norway

    G. Acharya

  3. Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden

    G. Acharya

Authors
  1. P. Bhide
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  2. M. Escriba
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  3. A. Srikantharajah
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  4. H. Joshi
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  5. A. Gudi
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  6. A. Shah
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  7. G. Acharya
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  8. R. Homburg
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Contributions

PB: Study idea and design, protocol development, data collection, analysis and interpretation, manuscript writing, editing and critical review. ME: Collection and analysis of data, editing of the manuscript and critical review. AS: Collection and analysis of data, editing of the manuscript and critical review. HJ: Collection and analysis of data, editing of the manuscript and critical review. AG: Data analysis and interpretation, editing of the manuscript and critical review. AS: Data analysis and interpretation, editing of the manuscript and critical review. GA: Study idea and design, protocol development, data analysis and interpretation, editing of the manuscript and critical review. RH: Study idea and design, protocol development, editing of the manuscript and critical review. All authors read the manuscript critically, commented on the draft and approved the final version before submission.

Corresponding author

Correspondence to P. Bhide.

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Conflict of interest

PB, ME, AS, HJ, AG, AS, GA, and RH have no conflict of interest to declare.

Ethical approval

Local Institutional Review Board approval was obtained (Ref No. 1675) and all data collection was done in accordance with data protection rules. This article does not contain any studies with animals performed by any of the authors. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Funding

No external funding was available for the study.

Informed consent

Informed consent was not required from individual participants included in the study and all data collection was done in accordance with data protection rules.

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Bhide, P., Escriba, M., Srikantharajah, A. et al. Anti-Mullerian hormone (AMH) and embryo quality assessed by time-lapse imaging (TLI): a cross-sectional observational study. Arch Gynecol Obstet 296, 583–587 (2017). https://doi.org/10.1007/s00404-017-4453-2

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  • DOI: https://doi.org/10.1007/s00404-017-4453-2

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