Skip to main content

Advertisement

SpringerLink
Log in

Cytomegalovirus and rubella seroprevalence in pregnant women in Izmir/Turkey: follow-up and results of pregnancy outcome

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

It is aimed to determine the Rubella and CMV prevalence in the pregnant women in Izmir and to research the effect of these infections on the course of pregnancy in the pregnant women exposed to infection during pregnancy.

Methods

The pregnant women applied to pregnancy outpatient department during 2001–2008 have been examined with enzyme-linked fluorescent assay (VIDAS; bioMérieux) method in terms of Rubella and CMV IgM and IgG antibodies and CMV IgG avidity test.

Results

Totally 5,959 pregnant women were included in the study. The seropositivity rates for Rubella and CMV were found as 97.8 and 98.3 %, IgM positivity rates were found as 0.37 and 0.18 %, respectively. Curettage was recommended to the pregnant women in which Rubella IgM positivity was detected in the first trimester of the pregnancy. Eight of the pregnant women in which IgM was found as positive after the 20th week of pregnancy were examined and three intrauterine growth retardation, one hypospadias and three normal deliveries were seen in these pregnant women. Any congenital anomaly finding was not detected in the pregnant women with positive CMV IgM.

Conclusions

Seroprevalence values are high for Rubella and CMV in our region. It can be recommended not to check the pregnant women routinely for this purpose with the good implementation of Rubella vaccine programs.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. World HealthOrganization (1999) World HealthOrganization report on infectious diseases: removing Obstaclesto Healthy Development. WHO report on infectious diseases. http://www.who.int. Accessed 23 Mar 2012

  2. Stegmann BJ, Carey JC (2002) TORCH infections. Toxoplasmosis, other (syphilis, varicellazoster, parvovirüs B19), Rubella, Cytomegalovirüs (CMV), and Herpes infections. Curr Womens Health Rep 2:253–258

    PubMed  Google Scholar 

  3. Ho M (2000) Cytomegalovirüs. In: Mandell GL, Douglas RG, Bennett JE (eds) Principles and practice of infectious disease, 3rd edn. Churchill Livingstone, New York, pp 1586–1596

  4. Lee JY, Bowden DS (2000) Rubella virüs replication and links to teratogenicity. Clin Microbiol Rev 13:571–587

    Article  PubMed  CAS  Google Scholar 

  5. Mims C, Dockrell HM, Goering RV, Roitt I, Wakelin D, Zuckerman M (2004) Medical Microbiology. Elsevier, Philadelphia, pp 313–322

  6. Hamdan HZ, Abdelbagi IE, Nasser NM, Adam I (2011) Seroprevalence of cytomegalovirüs and Rubella among pregnant women in western Sudan.Virol J 11(8):217

    Google Scholar 

  7. Onakewhor JU, Chiwuzie J (2011) Seroprevalence survey of Rubella infection in pregnancy at the University of Benin Teaching Hospital. Niger J Clin Pract 14:140–145

    Article  PubMed  CAS  Google Scholar 

  8. Vilibic-Cavlek T, Ljubin-Sternak S, Ban M, Kolaric B, Sviben M, Mlinaric-Galinovic G (2011) Seroprevalence of TORCH infections in women of childbearing age in Croatia. J Matern Fetal Neonat Med 24:280–283

    Article  Google Scholar 

  9. World Health Organization Position paper Rubella vaccine (2000). Wkly Epidemiol Rec 20(75):161–172

    Google Scholar 

  10. Robertson SE, Featherstone DA, Gacic-Dobo M, Hersh BS (2003) Rubella and congenital Rubella syndrome: global update. Rev Panam Salud Publica/Pan Am J Public Health 14:306–315

    Article  Google Scholar 

  11. Best JM, Banatvala JE (2004) Rubella. In: Zuckerman AJ, Banatvala JE, Pattison JR, Griffiths PD, Schoub BD (eds) Principles and practice of clinical virology, 5th edn. Wiley, West Suusex, pp 427–457

  12. De Santis M, Cavaliere AF, Straface G, Caruso A (2006) A.Rubella infection in pregnancy. Reprod Toxicol 21:390–398

    Article  PubMed  Google Scholar 

  13. Lin CC, Yang CY, Shih YL, Hsu HW, Yang TH et al (2011) Rubella seroepidemiologyan destimations of the catch-up immunisation rate and persistence of antibody titers in pregnant women in Taiwan. BJOG 118:706–712. doi:10.1111/j.1471-0528.2011.02903.x

    Article  PubMed  Google Scholar 

  14. Ghazi HO, Telmesani AM, Mahomed MF (2002) TORCH agents in pregnant Saudi women. Med Princ Pract 11(4):180–182

    Article  PubMed  Google Scholar 

  15. Uyar Y, Balci A, Akcali A, Cabar C (2008) Prevalence of Rubella and cytomegalo virüs anti bodies among pregnant women in northern Turkey. New Microbiolocica 31:451–455

    Google Scholar 

  16. Pehlivan E, Karaoğlu L, Ozen M, Günes G, Tekeroğlu MS et al (2007) Rubella seroprevalence in an unvaccinated pregnant population in Malatya, Turkey. Public Health 121:462–468

    Article  PubMed  CAS  Google Scholar 

  17. Wong A, Tan KH, Tee CS, Yeo CSH (2000) Seroprevalence of Cytomegalovirüs, Toxoplasma and Parvovirüs in pregnancy. Singap Med J41:151–155

    Google Scholar 

  18. Yılmazer M, Altındis M, Cevrioğlu S, Fenkci V, Aktepe O, Sırthan E (2004) Toxoplasma, Cytomegalovirüs, Rubella, Hepatitis B and Hepatitis C seropositivity rates in pregnant women who live in Afyon region. Med J Kocatepe 49:53

    Google Scholar 

  19. Satılmıs A, Güra A, Ongun H, Mendilcioğlu I, ÇolakD, Oygür N (2007) CMV seroconversion in pregnants and the incidence of congenital CMV infection. Turkish J Pediatr 49:30–36

  20. Ocak S, Zeteroglu S, Ozer C, Dolapcıoglu K, Gungören A (2007) Seroprevalence of Toxoplasmagondii, Rubella and cytomegalovirüs among pregnant women in southern Turkey. Scand J Infect Dis 39:231–234

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

  1. Obstetric and Gynecology, SB Seferihisar Necat Hepkon State Hospital, Izmir, Turkey

    Ahmet Uysal

  2. Obstetric and Gynecology, SB Aegean Maternity and Teaching Hospital, Izmir, Turkey

    Cüneyt Eftal Taner & Mete Cüce

  3. Department of Infection Disease, SB Tepecik Training and Teaching Hospital, Izmir, Turkey

    Sabri Atalay, Basak Göl & Sükran Köse

  4. Department of Radiology, SB Konak Maternity Hospital, Izmir, Turkey

    Fatma Uysal

Authors
  1. Ahmet Uysal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cüneyt Eftal Taner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mete Cüce
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sabri Atalay
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Basak Göl
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sükran Köse
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Fatma Uysal
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ahmet Uysal.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Uysal, A., Taner, C.E., Cüce, M. et al. Cytomegalovirus and rubella seroprevalence in pregnant women in Izmir/Turkey: follow-up and results of pregnancy outcome. Arch Gynecol Obstet 286, 605–608 (2012). https://doi.org/10.1007/s00404-012-2353-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-012-2353-z

Keywords

Search

Navigation