Abstract
In the last two decades, quantum dots nanomaterials have garnered a great deal of scientific interest because of their unique properties. Quantum dots (QDs) are inorganic fluorescent nanocrystals in the size range between 1 and 20 nm. Due to their structural properties, they possess distinctive properties and behave in different way from crystals in macro scale, in many branches of human life. Cadmium telluride quantum dots (CdTe QDs) were labeled with 68Ga radio nuclide for fast in vivo targeting and coincidence imaging of tumors. Using instant paper chromatography, the physicochemical properties of the Cadmium telluride quantum dots labeled with 68Ga NPs (68Ga@ CdTe QDs) were found high enough stable in organic phases, e.g., a human serum, to be reliably used in bioapplications. In vivo biodistribution of the 68Ga@ CdTe QDs nanoconposite was investigated in rats bearing fibro sarcoma tumor after various post-injection periods of time. The 68Ga NPs exhibited a rapid as well as high tumor uptake in a very short period of time (less than 10 min), resulting in an efficient tumor targeting/imaging agent. Meantime, the low lipophilicity of the 68Ga NPs caused to their fast excretion throughout the body by kidneys (as also confirmed by the urinary tract). Because of the short half-life of 68Ga radionuclide, the 68Ga@ CdTe QDs with an excellent tumor targeting/imaging and fast washing out from the body can be suggested as one of the most effective and promising nanomaterials in nanotechnology-based cancer diagnosis and therapy.
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References
J.A.J. Fitzpatrick, S.K. Andreko, L.A. Ernst, A.S. Waggoner, B. Ballou, M.P. Bruchez, Long-term persistence and spectral blue shifting of quantum dots in vivo. Nano Lett. 9, 2736–2741 (2009)
T. Jamieson, R. Bakhshi, D. Petrova, R. Pocock, M. Imani, A.M. Seifalian, Biological applications of quantum dots. Biomaterials 28, 4717–4732 (2007)
J.K. Jaiswal, H. Mattoussi, J.M. Mauro, S.M. Simon, Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat. Biotechnol. 21, 47–51 (2003)
J.K. Jaiswal, S.M. Simon, Potentials and pitfalls of fluorescent quantum dots for biological imaging. Trends Cell Biol. 14, 497–504 (2004)
C. Ding, A. Zhu, Y. Tian, Functional surface engineering of C-dots for fluorescent biosensing and in vivo bioimaging. Acc. Chem. Res. 47, 20–30 (2014)
E. Petryayeva, W.R. Algar, I.L. Medintz, Quantum dots in bioanalysis: a review of applications across various platforms for fluorescence spectroscopy and imaging. Appl. Spectrosc. 67, 215–252 (2013)
A. Shamirian, H.S. Afsari, A. Hassan, L.W. Miller, P.T. Snee, In vitro detection of hypoxia using a ratiometric quantum dot-based oxygen sensor. ACS Sens 1, 1244–1250 (2016)
M.E. Åkerman, W.C.W. Chan, P. Laakkonen, S.N. Bhatia, E. Ruoslahti, Nanocrystal targeting in vivo. Proc. Natl. Acad. Sci. USA 99, 12617–12621 (2002)
X. Gao, Y. Cui, R.M. Levenson, L.W.K. Chung, S. Nie, In vivo cancer targeting and imaging with semiconductor quantum dots. Nat. Biotechnol. 22, 969–976 (2004)
N.Y. Morgan, S. English, W. Chen, V. Chernomordik, A. Russo, P.D. Smith, A. Gandjbakhche, Real time in vivo non-invasive optical imaging using near-infrared fluorescent quantum dots. Acad. Radiol. 12, 313–323 (2005)
H. Xu, M.Y. Sha, E.Y. Wong, J. Uphoff, Y. Xu, J.A. Treadway, A. Truong, E. O’Brien, S. Asquith, M. Stubbins, N.K. Spurr, E.H. Lai, W. Mahoney, Multiplexed SNP genotyping using the Qbead™ system: a quantum dot-encoded microsphere-based assay. Nucleic Acids Res. 31, e43 (2003)
X. Gao, L. Yang, J.A. Petros, F.F. Marshall, J.W. Simons, S. Nie, In vivo molecular and cellular imaging with quantum dots. Curr. Opin. Biotechnol. 16, 63–72 (2005)
X. Michalet, F.F. Pinaud, L.A. Bentolila, J.M. Tsay, S. Doose, J.J. Li, G. Sundaresan, A.M. Wu, S.S. Gambhir, S. Weiss, Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307, 538–544 (2005)
A.M. Smith, H. Duan, A.M. Mohs, S. Nie, Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv. Drug Deliv. Rev. 60, 1226–1240 (2008)
B. Dubertret, P. Skourides, D.J. Norris, V. Noireaux, A.H. Brivanlou, A. Libchaber, In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science 298, 1759–1762 (2002)
R. Bakalova, Z. Zhelev, D. Kokuryo, L. Spasov, I. Aoki, T. Saga, Chemical nature and structure of organic coating of quantum dots is crucial for their application in imaging diagnostics. Int. J. Nanomed. 6, 1719–1732 (2011)
S. Jiang, K.Y. Win, S. Liu, C.P. Teng, Y. Zheng, M.Y. Han, Surface-functionalized nanoparticles for biosensing and imaging-guided therapeutics. Nanoscale 5, 3127–3148 (2013)
Y. Xing, Q. Chaudry, C. Shen, K.Y. Kong, H.E. Zhau, L.W. Chung, J.A. Petros, R.M. O’Regan, M.V. Yezhelyev, J.W. Simons, M.D. Wang, S. Nie, Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry. Nat. Protoc. 2, 1152–1165 (2007)
A.M. Smith, S. Dave, S. Nie, L. True, X. Gao, Multicolor quantum dots for molecular diagnostics of cancer. Expert Rev. Mol. Diagn. 6, 231–244 (2006)
A. Robe, E. Pic, H.-P. Lassalle, L. Bezdetnaya, F. Guillemin, F. Marchal, Quantum dots in axillary lymph node mapping: biodistribution study in healthy mice. BMC Cancer 8, 111 (2008)
M. Takeda, H. Tada, H. Higuchi, Y. Kobayashi, M. Kobayashi, Y. Sakurai, T. Ishida, N. Ohuchi, In vivo single molecular imaging and sentinel node navigation by nanotechnology for molecular targeting drug-delivery systems and tailor-made medicine. Breast Cancer 15, 145–152 (2008)
A. Liu, S. Peng, J.C. Soo, M. Kuang, P. Chen, H. Duan, Quantum dots with phenylboronic acid tags for specific labeling of sialic acids on living cells. Anal. Chem. 83, 1124–1130 (2011)
L.E. Page, X. Zhang, C.M. Tyrakowski, C.T. Ho, P.T. Snee, Synthesis and characterization of DNA-quantum dot conjugates for the fluorescence ratiometric detection of unlabelled DNA. Analyst 141, 6251–6258 (2016)
O. Mashinchian, M. Johari-Ahar, B. Ghaemi, M. Rashidi, J. Barar, Y. Omidi, Impacts of quantum dots in molecular detection and bioimaging of cancer. Bioimpacts 4, 149–166 (2014)
M. Geszke, M. Murias, L. Balan, G. Medjahdi, J. Korczynski, M. Moritz, J. Lulek, R. Schneider, Folic acid-conjugated core/shell ZnS: Mn/ZnS quantum dots as targeted probes for two photon fluorescence imaging of cancer cells. Acta Biomater. 7, 1327–1338 (2011)
I.B. Bwatanglang, F. Mohammad, N.A. Yusof, J. Abdullah, M.Z. Hussein, N.B. Alitheen, N. Abu, Folic acid targeted Mn:ZnS quantum dots for theranostic applications of cancer cell imaging and therapy. Int. J. Nanomed. 11, 413–428 (2016)
A. SalmanOgli, Nanobio applications of quantum dots in cancer: imaging, sensing, and targeting. Cancer Nanotechnol. 2, 1–19 (2011)
H. Lee, C. Kim, D. Lee, J.H. Park, P.C. Searson, K.H. Lee, Optical coding of fusion genes using multicolor quantum dots for prostate cancer diagnosis. Int. J. Nanomed. 12, 4397–4407 (2017)
S. Li, S. Zhou, Y. Li, X. Li, J. Zhu, L. Fan, S. Yang, Exceptionally high payload of the IR780 iodide on folic acid-functionalized graphene quantum dots for targeted photothermal therapy. ACS Appl. Mater. Interfaces (2017). doi:10.1021/acsami.7b07267
W. Tao, X. Ji, X. Xu, M. Ariful Islam, Z. Li, S. Chen, P. E. Saw, H. Zhang, Z. Bharwani, Z. Guo, J. Shi, O. Farokhzad, Antimonene quantum dots: synthesis and application as near-infrared photothermal agents for effective cancer therapy. Angew. Chem. Int. Ed. Engl. (2017). doi:10.1002/anie.201703657
F. Khodadadei, S. Safarian, N. Ghanbari, Methotrexate-loaded nitrogen-doped graphene quantum dots nanocarriers as an efficient anticancer drug delivery system. Mater. Sci. Eng. C Mater. Biol. Appl. 79, 280–285 (2017)
P. Nigam Joshi, S. Agawane, M.C. Athalye, V. Jadhav, D. Sarkar, R. Prakash, Multifunctional inulin tethered silver-graphene quantum dots nanotheranostic module for pancreatic cancer therapy. Mater. Sci. Eng. C Mater. Biol. Appl. 78, 1203–1211 (2017)
Y. Qiu, B. Zhou, X. Yang, D. Long, Y. Hao, P. Yang, Novel single-cell analysis platform based on a solid-state zinc-coadsorbed carbon quantum dots electrochemiluminescence probe for the evaluation of CD44 expression on breast cancer cells. ACS Appl. Mater. Interfaces 9, 16848–16856 (2017)
K. Li, C. Xia, B. Wang, H. Chen, T. Wang, Q. He, H. Cao, Y. Wang, Effects of quantum dots on the ROS amount of liver cancer stem cells. Colloids Surf. B Biointerfaces 155, 193–199 (2017)
Z. Fan, S. Zhou, C. Garcia, L. Fan, J. Zhou, pH-Responsive fluorescent graphene quantum dots for fluorescence-guided cancer surgery and diagnosis. Nanoscale 9, 4928–4933 (2017)
S. Kim, Y.T. Lim, E.G. Soltesz, A.M. De Grand, J. Lee, A. Nakayama, J.A. Parker, T. Mihaljevic, R.G. Laurence, D.M. Dor, L.H. Cohn, M.G. Bawendi, J.V. Frangioni, Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat. Biotechnol. 22, 93–97 (2004)
E.G. Soltesz, S. Kim, R.G. Laurence, A.M. DeGrand, C.P. Parungo, D.M. Dor, L.H. Cohn, M.G. Bawendi, J.V. Frangioni, T. Mihaljevic, Intraoperative sentinel lymph node mapping of the lung using near-infrared fluorescent quantum dots. Ann. Thorac. Surg. 79, 269–277 (2005)
M.E.G. Soltesz, P.S. Kim, P.S.-W. Kim, B.R.G. Laurence, B.A.M.D. Grand, M.C.P. Parungo, M.L.H. Cohn, P.M.G. Bawendi, M.J.V. Frangioni, Sentinel lymph node mapping of the gastrointestinal tract by using invisible light. Ann. Surg. Oncol. 13, 386–396 (2005)
C.P. Parungo, S. Ohnishi, S.-W. Kim, S. Kim, R.G. Laurence, E.G. Soltesz, F.Y. Chen, Y.L. Colson, L.H. Cohn, M.G. Bawendi, J.V. Frangioni, Intraoperative identification of esophageal sentinel lymph nodes with near-infrared fluorescence imaging. J. Thorac. Cardiovasc. Surg. 129, 844–850 (2005)
V. Poderys, M. Matulionyte, A. Selskis, R. Rotomskis, Interaction of water-soluble CdTe quantum dots with bovine serum albumin. Nanoscale Res. Lett. 6, 1–6 (2010)
N. Abdullah Al, J.-E. Lee, I. In, H. Lee, K.D. Lee, J.H. Jeong, S.Y. Park, Target delivery and cell imaging using hyaluronic acid-functionalized graphene quantum dots. Mol. Pharm. 10, 3736–3744 (2013)
J. Wang, P. Jiang, Z. Han, L. Qiu, C. Wang, B. Zheng, J. Xia, Fast self-assembly kinetics of quantum dots and a dendrimeric peptide ligand. Langmuir 28, 7962–7966 (2012)
H. Chen, Z. Wang, S. Zong, P. Chen, D. Zhu, L. Wu, Y. Cui, A graphene quantum dot-based FRET system for nuclear-targeted and real-time monitoring of drug delivery. Nanoscale 7, 15477–15486 (2015)
C.E. Probst, P. Zrazhevskiy, V. Bagalkot, X. Gao, Quantum dots as a platform for nanoparticle drug delivery vehicle design. Adv. Drug Deliv. Rev. 65, 703–718 (2013)
A. Shamirian, H. Samareh Afsari, D. Wu, L.W. Miller, P.T. Snee, Ratiometric QD-FRET sensing of aqueous H2S in vitro. Anal. Chem. 88, 6050–6056 (2016)
R.S. Yang, L.W. Chang, J.P. Wu, M.H. Tsai, H.J. Wang, Y.C. Kuo, T.K. Yeh, C.S. Yang, P. Lin, Persistent tissue kinetics and redistribution of nanoparticles, quantum dot 705, in mice: ICP-MS quantitative assessment. Environ. Health Perspect. 115, 1339–1343 (2007)
M.L. Schipper, Z. Cheng, S.-W. Lee, L.A. Bentolila, G. Iyer, J. Rao, X. Chen, A.M. Wu, S. Weiss, S.S. Gambhir, microPET-Based biodistribution of quantum dots in living mice. J. Nucl. Med. 48, 1511–1518 (2007)
M.L. Schipper, G. Iyer, A.L. Koh, Z. Cheng, Y. Ebenstein, A. Aharoni, S. Keren, L.A. Bentolila, J. Li, J. Rao, X. Chen, U. Banin, A.M. Wu, R. Sinclair, S. Weiss, S.S. Gambhir, Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice. Small 5, 126–134 (2009)
H.S. Choi, W. Liu, P. Misra, E. Tanaka, J.P. Zimmer, B. Itty Ipe, M.G. Bawendi, J.V. Frangioni, Renal clearance of quantum dots. Nat. Biotechnol. 25, 1165–1170 (2007)
M. Sun, G. Sundaresan, P. Jose, L. Yang, D. Hoffman, N. Lamichhane, J. Zweit, Highly stable intrinsically radiolabeled indium-111 quantum dots with multidentate zwitterionic surface coating: dual modality tool for biological imaging. J. Mater. Chem. B 2, 4456–4466 (2014)
D. Bargheer, A. Giemsa, B. Freund, M. Heine, C. Waurisch, G.M. Stachowski, S.G. Hickey, A. Eychmuller, J. Heeren, P. Nielsen, The distribution and degradation of radiolabeled superparamagnetic iron oxide nanoparticles and quantum dots in mice. Beilstein J. Nanotechnol. 6, 111–123 (2015)
D.W. Jonathan, J.K. Steve, M. Saed, D. Sheng, S.W. Jonathan, R. Tina, A. James, J.R. Adam, In vivo SPECT/CT imaging and biodistribution using radioactive Cd 125 m Te/ZnS nanoparticles. Nanotechnology 18, 175103 (2007)
Y. Fazaeli, O. Akhavan, R. Rahighi, M.R. Aboudzadeh, E. Karimi, H. Afarideh, In vivo SPECT imaging of tumors by 198, 199Au-labeled graphene oxide nanostructures. Mater. Sci. Eng. C 45, 196–204 (2014)
Y. Fazaeli, S. Feizi, A.R. Jalilian, A. Hejrani, Grafting of [64Cu]-TPPF20 porphyrin complex on Functionalized nano-porous MCM-41 silica as a potential cancer imaging agent. Appl. Radiat. Isot 112, 13–19 (2016)
Y. Fazaeli, Z. Asgari, DTPA-functionalized nano-porous MCM-41 silica: a new potential nanoengineered labeled composite for diagnostic applications. Iran. J. Sci. Technol. Trans. A Sci. 1–8 (2016). doi:10.1007/s40995-016-0047-2
J.C. Bonilla, F. Bozkurt, S. Ansari, N. Sozer, J.L. Kokini, Applications of quantum dots in food science and biology. Trends Food Sci. Technol. 53, 75–89 (2016)
Y. Fazaeli, A. Jalilian, M. Amini, A. Rahiminejad-kisomi, S. Rajabifar, F. Bolourinovin, S. Moradkhani, Preparation and preliminary evaluation of [67 Ga]-tetra phenyl porphyrin complexes as possible imaging agents. J. Radioanal. Nucl. Chem. 288, 17–24 (2011)
B.S. Sekhon, S.R. Kamboj, Inorganic nanomedicine—part 2. Nanomedicine 6, 612–618 (2010)
K.K. Banger, S.A. Duraj, P.E. Fanwick, A.F. Hepp, R.A. Martuch, Synthesis, and structural characterization of [{CH3(C5H4 N)}Ga(SCH2(CO)O)2]–[(4-MepyH)]+, a novel Ga(III) five-coordinate complex. J. Coord. Chem. 56, 307–312 (2003)
S.A. Duraj, A.F. Hepp, R. Woloszynek, J.D. Protasiewicz, M. Dequeant, T. Ren, Synthesis of two new group 13 benzoato–chloro complexes: a structural study of gallium and indium chelating carboxylates. Inorganica Chimica Acta 365, 54–60 (2011)
Y.-P. Tong, Y.-W. Lin, Synthesis and structure of a novel mixed-ligand electroluminescence-relevant complex of gallium(III) with 2-(2′-hydroxylphenyl)benzothiazole and acetate, and a theoretical investigation on effect of ancillary ligand on solid stacking structure, electroluminescent wavelength shift and other changes in photophysical properties compared to its conventional tris-chelate electroluminescence-relevant counterpart. Synth. Metals 160, 1662–1667 (2010)
W. Uhl, A.-C. Fick, T. Spies, G. Geiseler, K. Harms, Gallium–gallium bonds as key building blocks for the formation of large organometallic macrocycles, on the way to a mesoporous molecule. Organometallics 23, 72–75 (2004)
X. Ming Wang, R. Qing Fan, L. Sheng Qiang, W. Qi Li, P. Wang, H. Jie Zhang, Y. Lin Yang, Tunable luminescence from rare 2D Ga(iii)/In(iii) coordination polymers coexisting with three different conjugated system aromatic ligands. Chem. Commun. 50, 5023–5026 (2014)
H.R. Hoveyda, S.J. Rettig, C. Orvig, Coordination chemistry of 2-(2′-hydroxyphenyl)-2-benzoxazole with gallium(III) and aluminum(III): two uncommon Group 13 metal environments stabilized by a biologically relevant binding group. Inorg. Chem. 32, 4909–4913 (1993)
C. Volkringer, T. Loiseau, N. Guillou, G. Ferey, E. Elkaim, A. Vimont, XRD and IR structural investigations of a particular breathing effect in the MOF-type gallium terephthalate MIL-53(Ga). Dalton Trans. (12), 2241–2249 (2009). doi:10.1039/b817563b
D.L. Reger, S.J. Knox, L. Lebioda, Organometallic complexes of gallium stabilized by the dihydrobis(pyrazolyl)borate ligand. Organometallics 9, 2218–2222 (1990)
J. Notni, K. Pohle, J.A. Peters, H. Görls, C. Platas-Iglesias, Structural Study of Ga(III), In(III), and Fe(III) complexes of triaza-macrocycle based ligands with N3S3 donor set. Inorg. Chem. 48, 3257–3267 (2009)
R.J. Motekaitis, A.E. Martell, S.A. Koch, J. Hwang, D.A. Quarless, M.J. Welch, The gallium(III) and indium(III) complexes of tris(2-mercaptobenzyl)amine and tris(2-hydroxybenzyl)amine. Inorg. Chem. 37, 5902–5911 (1998)
A.M. Vălean, S. Gómez-Ruiz, P. Lönnecke, I. Silaghi-Dumitrescu, L. Silaghi-Dumitrescu, E. Hey-Hawkins, When arsine makes the difference: chelating phosphino and bridging arsinoarylthiolato gallium complexes. Inorg. Chem. 47, 11284–11293 (2008)
K. Kowolik, M. Shanmugam, T.W. Myers, C.D. Cates, L.A. Berben, A redox series of gallium(iii) complexes: ligand-based two-electron oxidation affords a gallium-thiolate complex. Dalton Trans. 41, 7969–7976 (2012)
I.L. Medintz, A.R. Clapp, H. Mattoussi, E.R. Goldman, B. Fisher, J.M. Mauro, Self-assembled nanoscale biosensors based on quantum dot FRET donors. Nat. Mater. 2, 630–638 (2003)
Y. Feng, L. Liu, S. Hu, P. Zou, J. Zhang, C. Huang, Y. Wang, S. Wang, X. Zhang, Efficient fluorescence energy transfer system between fluorescein isothiocyanate and CdTe quantum dots for the detection of silver ions. Luminescence 31, 356–363 (2016)
H. Tao, X. Liao, C. Sun, X. Xie, F. Zhong, Z. Yi, Y. Huang, A carbon dots-CdTe quantum dots fluorescence resonance energy transfer system for the analysis of ultra-trace chlortoluron in water. Spectrochimica Acta Part A Mol. Biomol. Spectrosc. 136, 1328–1334 (2015). (Part C)
Y. Xiao, P.E. Barker, Semiconductor nanocrystal probes for human metaphase chromosomes. Nucleic Acids Res. 32, e28 (2004)
J. Kim, B.T. Huy, K. Sakthivel, H.J. Choi, W.H. Joo, S.K. Shin, M.J. Lee, Y.-I. Lee, Highly fluorescent CdTe quantum dots with reduced cytotoxicity-A Robust biomarker. Sens. Bio Sens. Res. 3, 46–52 (2015)
S. Rieger, R.P. Kulkarni, D. Darcy, S.E. Fraser, R.W. Koster, Quantum dots are powerful multipurpose vital labeling agents in zebrafish embryos. Dev. Dyn. 234, 670–681 (2005)
S.A.O. Gomes, C.S. Vieira, D.B. Almeida, J.R. Santos-Mallet, R.F.S. Menna-Barreto, C.L. Cesar, D. Feder, CdTe and CdSe quantum dots cytotoxicity: a comparative study on microorganisms. Sensors (Basel, Switzerland) 11, 11664–11678 (2011)
L. Yang, Y. Li, Simultaneous detection of Escherichia coli O157:H7 and Salmonella Typhimurium using quantum dots as fluorescence labels. Analyst 131, 394–401 (2006)
D.R. Larson, W.R. Zipfel, R.M. Williams, S.W. Clark, M.P. Bruchez, F.W. Wise, W.W. Webb, Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science 300, 1434 (2003)
D. Gerion, F. Pinaud, S.C. Williams, W.J. Parak, D. Zanchet, S. Weiss, A.P. Alivisatos, Synthesis and properties of biocompatible water-soluble silica-coated CdSe/ZnS semiconductor quantum dots. J. Phys. Chem. B 105, 8861–8871 (2001)
K.C. Weng, C.O. Noble, B. Papahadjopoulos-Sternberg, F.F. Chen, D.C. Drummond, D.B. Kirpotin, D. Wang, Y.K. Hom, B. Hann, J.W. Park, Targeted tumor cell internalization and imaging of multifunctional quantum dot-conjugated immunoliposomes in vitro and in vivo. Nano Lett. 8, 2851–2857 (2008)
S. Jin, Y. Hu, Z. Gu, L. Liu, H.-C. Wu, Application of quantum dots in biological imaging. J. Nanomater. 2011, 13 (2011)
P. Sun, H. Zhang, C. Liu, J. Fang, M. Wang, J. Chen, J. Zhang, C. Mao, S. Xu, Preparation and characterization of Fe3O4/CdTe magnetic/fluorescent nanocomposites and their applications in immuno-labeling and fluorescent imaging of cancer cells. Langmuir 26, 1278–1284 (2010)
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The authors would like to thank Mr. Mehraban Pouladi for his kind help.
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Fazaeli, Y., Zare, H., Karimi, S. et al. Novel aspects of application of cadmium telluride quantum dots nanostructures in radiation oncology. Appl. Phys. A 123, 507 (2017). https://doi.org/10.1007/s00339-017-1125-9
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DOI: https://doi.org/10.1007/s00339-017-1125-9