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Antimicrobial evaluation of novel buccoadhesive films containing Myrrh extract

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Abstract

This study describes the formulation of new buccoadhesive films containing Myrrh extract as a natural and safe antimicrobial agent to give a long local medication. Buccoadhesive films of Myrrh extract were developed using solvent evaporation technique. The fabricated Myrrh extract films were evaluated for their palatability, weight, surface pH, and their content uniformity. In addition, tensile strength and the percentage of elongation of the films as well as in vitro mucoadhesive time were determined. Also, the films were tested for their antimicrobial activities. Obtained results showed that the tested films are elegant in appearance and have neutral pH, palatable by volunteers and have good tensile strength and elasticity. They also exhibited antibacterial activities against different types of bacterial strains as well as antifungal activity against Candida albicans.

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Acknowledgements

The authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for its funding the work through the research group Project Number RG-1435-299.

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Authors and Affiliations

  1. Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia

    Sayed H. Auda, Mounir M. Salem-Bekhit, Fars K. Alanazi, Ibrahim A. Alsarra & Faiyaz Shakeel

  2. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

    Sayed H. Auda

  3. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

    Mounir M. Salem-Bekhit

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  1. Sayed H. Auda
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  2. Mounir M. Salem-Bekhit
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  3. Fars K. Alanazi
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  4. Ibrahim A. Alsarra
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  5. Faiyaz Shakeel
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Correspondence to Faiyaz Shakeel.

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Auda, S.H., Salem-Bekhit, M.M., Alanazi, F.K. et al. Antimicrobial evaluation of novel buccoadhesive films containing Myrrh extract. Polym. Bull. 74, 4041–4054 (2017). https://doi.org/10.1007/s00289-017-1946-x

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  • DOI: https://doi.org/10.1007/s00289-017-1946-x

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