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Factor V Leiden and G20210A prothrombin mutations in patients with recurrent pregnancy loss: data from the southeast of Turkey

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Abstract

Factor V Leiden (FV-Leiden) and prothrombin gene mutations (FII G20210A) are well-established independent risk factors for thrombosis. In the recent years, many studies have suggested that these mutations are associated with an increased risk of recurrent pregnancy loss (RPL). We aimed to investigate the prevalence of these molecular defects in subjects with a history of early RPL. One hundred and fourteen women with three or more consecutive unexplained first-trimester miscarriages were compared to 185 parous women with uncomplicated pregnancies from the same ethnic origin. The presence of FV-Leiden and FII G20210A mutations was assessed by polymerase chain reaction analysis. Overall, 11 out of the 114 women with early RPL (9.6%) had either FV-Leiden or FII G20210A mutation, as compared with 16 out of the 185 women with normal pregnancies (8.6%; p = 0.756). The prevalence of FV-Leiden mutation was 7.9% (9/114) in patient group, compared with 7% (13/185) in control group (p = 0.780). One hundred and two patients were primary and 12 were secondary aborters. All FV-Leiden positive cases were primary aborters (8.8%; 9/102, p = 0.584). Concerning the FII G20210A, two out of 114 (1.7%) were first-trimester RPL (primary aborters) and three out of 185 (1.6%) controls were carriers of the FII G20210A mutation (1.7 vs 1.6%, p = 0.931). The results obtained from patients with first-trimester RPL and the control group have no statistical significant differences in the prevalence of FV-Leiden and FII G20210A mutations. These results suggest that mutations have no role in etiology of first-trimester recurrent abortions.

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Authors and Affiliations

  1. Internal Medicine, Department of Hematology–Oncology, Dicle University, 21280, Diyarbakir, Turkey

    Abdullah Altintas, Semir Pasa, Timucin Cil & Orhan Ayyildiz

  2. Department of Obstetrics and Gynecology, Dicle University, Diyarbakir, Turkey

    Nurten Akdeniz

  3. Molecular Genetics and Hematology Laboratory, Dicle University, Diyarbakir, Turkey

    Murat Yurt & Sabri Batun

  4. Department of Molecular Genetics, Dicle University, Diyarbakir, Turkey

    Hilmi Isi

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  1. Abdullah Altintas
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  2. Semir Pasa
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Correspondence to Abdullah Altintas.

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Altintas, A., Pasa, S., Akdeniz, N. et al. Factor V Leiden and G20210A prothrombin mutations in patients with recurrent pregnancy loss: data from the southeast of Turkey. Ann Hematol 86, 727–731 (2007). https://doi.org/10.1007/s00277-007-0327-1

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  • DOI: https://doi.org/10.1007/s00277-007-0327-1

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