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Comparison of the Prognostic Value of Tumour- and Patient-Related Factors in Patients Undergoing Potentially Curative Resection of Oesophageal Cancer

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Abstract

Background

Evidence is increasing that elevated systemic inflammation is associated with poor survival in patients with oesophageal carcinoma. However, it is not yet established if any specific component of systemic inflammatory response is a better predictor of cancer survival. The aim of the present study was to compare the predictive value of selected markers of systemic inflammation in patients who undergo surgical resection of oesophageal cancer.

Methods

One hundred twelve patients who underwent potentially curative resection for oesophageal carcinoma, including type I and type II tumours of the gastro-oesophageal junction (Siewert and Stein in Dis Esophagus 9:173–182, 1996), between 1996 and 2008 were included in the study. Patients had laboratory measurement of white cells, neutrophils, lymphocytes, platelet counts, albumin, and C-reactive protein. Glasgow Prognostic Score (mGPS), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and metastatic lymph node ratio (LNR) were calculated.

Results

On multivariate analysis, only the LNR (HR 2.87, 95% CI 1.99-4.15, p < 0.001) and the mGPS (HR 4.31, 95% CI 2.20-8.45, p < 0.001) were independently associated with cancer-specific survival in oesophageal cancer. An elevated mGPS was associated with high white cell count (p < 0.05) and poorer survival (p = 0.001).

Conclusion

The present study indicates that the mGPS, an acute-phase protein-based prognostic score, better predicts cancer survival compared with the cellular components of systemic inflammation in patients with oesophageal carcinoma.

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Acknowledgment

We acknowledge the support and interest of Margaret McKernan and Robert Stuart.

Disclosure

The authors have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Academic Unit of Surgery, School of Medicine, University of Glasgow, Wolfson Medical School Bldg, University Ave, Glasgow, G12 8QQ, Scotland, UK

    Sumanta Dutta, Andrew B. C. Crumley, Grant M. Fullarton, Paul G. Horgan & Donald C. McMillan

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  1. Sumanta Dutta
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  2. Andrew B. C. Crumley
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  3. Grant M. Fullarton
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  4. Paul G. Horgan
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  5. Donald C. McMillan
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Correspondence to Sumanta Dutta.

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Dutta, S., Crumley, A.B.C., Fullarton, G.M. et al. Comparison of the Prognostic Value of Tumour- and Patient-Related Factors in Patients Undergoing Potentially Curative Resection of Oesophageal Cancer. World J Surg 35, 1861–1866 (2011). https://doi.org/10.1007/s00268-011-1130-7

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