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MRI of superficial soft tissue masses: analysis of features useful in distinguishing between benign and malignant lesions

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Abstract

Aim

To identify the MRI features of superficial soft tissue masses, that may allow differentiation between malignant and non-malignant lesions.

Method

A total of 136 consecutive patients referred to a supra-regional musculoskeletal oncology center over a 10-year period with the diagnosis of a superficial soft tissue mass were included in this retrospective study. Features analyzed included patient demographics, lesion size, MRI signal characteristics, margins, lobulation, hemorrhage, necrosis, fascial edema, relationship to the fascia, as well as involvement of the skin. Comparison was then made with the final histological diagnosis.

Results

Of the patients reviewed, 58 were male and 78 were female, and the mean age was 49.9 years. The mean age for malignant lesions was 57.9 years, and that for non-neoplastic and benign conditions 41.9 years (p < 0.001). A significant relationship was identified between malignancy and lobulation (p < 0.01), hemorrhage (p < 0.001), fascial edema (p < 0.001), hemorrhage (p < 0.0001) and necrosis (p < 0.001). The relationship between skin thickening and skin contact and malignancy was also found to be significant. However, size was not found to be an important determining factor for malignancy, with a significant proportion of malignant superficial sarcomas measuring less than 5 cm in maximal diameter.

Conclusions

This study has shown that a significant proportion of malignant superficial sarcomas measured less than 5 cm in maximal diameter. Fascial edema, skin thickening, skin contact, hemorrhage, and necrosis were found to be highly significant factors indicative of malignancy. Lobulation and peritumoral edema were also significant MRI features.

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Acknowledgments

Sincere thanks to Dr. Gisela Dimigen, retired senior lecturer, Department of Psychology, Glasgow University, for her help with statistical analysis.

Conflict of interest

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Royal National Orthopaedic Hospital, Stanmore, UK

    Michele Calleja, Marion Dimigen & Asif Saifuddin

Authors
  1. Michele Calleja
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  2. Marion Dimigen
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  3. Asif Saifuddin
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Correspondence to Michele Calleja.

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Calleja, M., Dimigen, M. & Saifuddin, A. MRI of superficial soft tissue masses: analysis of features useful in distinguishing between benign and malignant lesions. Skeletal Radiol 41, 1517–1524 (2012). https://doi.org/10.1007/s00256-012-1385-6

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  • DOI: https://doi.org/10.1007/s00256-012-1385-6

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