Abstract
Background
Goiter is frequently the first indicator of thyroid disease in children.
Objective
To evaluate the usefulness of ultrasonography (US) in the identification of potential malignant nodules and autoimmune thyroiditis in children with diffuse goiter.
Materials and methods
This study consisted of 113 patients <20 years with a diffuse goiter who underwent thyroid US. Parenchymal echogenicity and the presence of nodules and abnormal lymph nodes were evaluated on US; if a thyroid nodule was detected, its characteristics were analyzed. The diagnostic accuracy of the US findings in the diagnosis of autoimmune thyroid disease was assessed.
Results
Thyroid nodules were detected on US in 72 of the 113 (63.7%) patients. Of these, 65 (90.3%) had probably benign nodules and 4 (5.6%) patients had nodules suspicious of malignancy. The remaining had indeterminate nodules only. In one child with suspected malignant nodules, papillary thyroid cancer with coexisting autoimmune thyroiditis was confirmed. Hypoechogenicity was visualized in 23 (88.5%) patients with autoimmune thyroiditis and 12 (85.7%) with Graves disease. The sensitivity and specificity of micronodulation for autoimmune thyroiditis were 53.9% and 98.3%, respectively.
Conclusion
Although the potential for malignant nodules is relatively low in children with diffuse goiter, US can detect focal thyroid disease and characterize the nodules. US thus plays a useful role in excluding autoimmune thyroiditis in this population.
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References
Muirhead S (2001) Diagnostic approach to goitre in children. Paediatr Child Health 6:195–199
Canadian Pediatric Thyroid Nodule (CaPTN) Study Group (2008) The Canadian Pediatric Thyroid Nodule Study: an evaluation of current management practices. J Pediatr Surg 43:826–830
Campos LA, Picado SM, Guimarães AV et al (2012) Thyroid papillary carcinoma associated to Hashimoto’s thyroiditis. Braz J Otorhinolaryngol 78:77–80
Moon W, Baek JH, Jung SL et al (2011) Ultrasonography and the ultrasound-based management of thyroid nodules: consensus statement and recommendations. Korean J Radiol 12:1–13
Goldfarb M, Gondek SS, Sanchez Y et al (2012) Clinic-based ultrasound can predict malignancy in pediatric thyroid nodules. Thyroid 22:827–831
Kaur J, Srinivasan R, Arora SK et al (2012) Fine-needle aspiration in the evaluation of thyroid lesions in children. Diagn Cytopathol 40:E33–E37
Roy R, Kouniavsky G, Schneider E et al (2011) Predictive factors of malignancy in pediatric thyroid nodules. Surgery 150:1228–1233
Lee JH, Kim Y, Choi JW et al (2013) The association between papillary thyroid carcinoma and histologically proven Hashimoto’s thyroiditis: a meta-analysis. Eur J Endocrinol 168:343–349
Tamimi DM (2002) The association between chronic lymphocytic thyroiditis and thyroid tumors. Int J Surg Pathol 10:141–146
Corrias A, Cassio A, Weber G et al (2008) Thyroid nodules and cancer in children and adolescents affected by autoimmune thyroiditis. Arch Pediatr Adolesc Med 162:526–531
Pedersen OM, Aardal NP, Larssen TB et al (2000) The value of ultrasonography in predicting autoimmune thyroid disease. Thyroid 10:251–259
Kim DW, Eun CK, In HS et al (2010) Sonographic differentiation of asymptomatic diffuse thyroid disease from normal thyroid: a prospective study. AJNR Am J Neuroradiol 31:1956–1960
Nordmeyer JP, Shafeh TA, Heckmann C (1990) Thyroid sonography in autoimmune thyroiditis. A prospective study on 123 patients. Acta Endocrinol 122:391–395
Marwaha RK, Tandon N, Kanwar R et al (2008) Evaluation of the role of ultrasonography in diagnosis of autoimmune thyroiditis in goitrous children. Indian Pediatr 45:279–284
Yeh HC, Futterweit W, Gilbert P (1996) Micronodulation: ultrasonographic sign of Hashimoto thyroiditis. J Ultrasound Med 15:813–819
Ralls PW, Mayekawa DS, Lee KP et al (1988) Color-flow Doppler sonography in Graves disease: “thyroid inferno.” AJR Am J Roentgenol 150:781–784
Menzilcioglu MS, Duymus M, Gungor G et al (2014) The value of real-time ultrasound elastography in chronic autoimmune thyroiditis. Br J Radiol 87:20140604
Sporea I, Sirli R, Bota S et al (2012) ARFI elastography for the evaluation of diffuse thyroid gland pathology: preliminary results. World J Radiol 28:174–178
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Lee, S.J., Lim, GY., Kim, J.Y. et al. Diagnostic performance of thyroid ultrasonography screening in pediatric patients with a hypothyroid, hyperthyroid or euthyroid goiter. Pediatr Radiol 46, 104–111 (2016). https://doi.org/10.1007/s00247-015-3435-4
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DOI: https://doi.org/10.1007/s00247-015-3435-4