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Biocompatibility, encrustation and biodegradation of ofloxacine and silver nitrate coated poly-L-lactic acid stents in rabbit urethra

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Abstract.

The purpose of this study was to evaluate the biocompatibility, encrustation and biodegradation properties of silver nitrate and ofloxacine blended caprolactone-L-lactide copolymer coated self-reinforced poly-L-lactic acid (SR-PLLA) urospirals in situ in the male rabbit urethra. SR-PLLA urospirals coated with 10% by weight silver nitrate or 5% by weight ofloxacine blended copolymer or pure copolymer were inserted into the posterior urethra of 18 male rabbits. No prophylactic antibiotics were given. The animals were sacrificed 1 or 6 months after insertion. Urethral tissue reactions were histologically scored semiquantitavely and the appearence of the stents assessed using scanning electron microscopy. The biodegradation time of SR-PLLA stents was remarkably reduced by the caprolactone coating. Silver nitrate and ofloxacine blended copolymer coated urospirals caused less tissue reaction than urospirals with a pure copolymer coating. Silver nitrate coating effectively prevented biofilm formation and stent encrustation. Silver nitrate and ofloxacine blended copolymer coated SR-PLLA urospirals had good biocompatibility properties in rabbit urethra. In particular, coating with silver nitrate may provide possibilities of preventing bacterial adhesion to bioabsorbable stents.

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Authors and Affiliations

  1. Department of Urology, Kuusankoski District Hospital, Kuusankoski, 45750 Sairaalamäki, Finland, , , , ,

    Markku Multanen

  2. Department of Urology, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland, , , , ,

    Teuvo L. Tammela

  3. Department of Pathology, Kanta-Häme Central Hospital, Hämeenlinna, Finland, , , , ,

    Marita Laurila

  4. Laboratory of Polymer Technology, Helsinki University of Technology, Espoo, Finland, , , , ,

    Jukka Seppälä

  5. Institute of Biomaterials, Tampere University of Technology, Tampere, Finland, , , , ,

    Tero Välimaa & Pertti Törmälä

  6. Department of Urology, Päijät-Häme Central Hospital, Lahti, Finland, , , , ,

    Martti Talja

Authors
  1. Markku Multanen
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  2. Teuvo L. Tammela
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  3. Marita Laurila
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  4. Jukka Seppälä
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  5. Tero Välimaa
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  6. Pertti Törmälä
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  7. Martti Talja
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Multanen, M., Tammela, T.L., Laurila, M. et al. Biocompatibility, encrustation and biodegradation of ofloxacine and silver nitrate coated poly-L-lactic acid stents in rabbit urethra. Urol Res 30, 227–232 (2002). https://doi.org/10.1007/s00240-002-0252-7

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  • DOI: https://doi.org/10.1007/s00240-002-0252-7

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