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Apparent brain temperature imaging with multi-voxel proton magnetic resonance spectroscopy compared with cerebral blood flow and metabolism imaging on positron emission tomography in patients with unilateral chronic major cerebral artery steno-occlusive disease

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Abstract

Purpose

The purpose of the present study was to determine whether apparent brain temperature imaging using multi-voxel proton magnetic resonance (MR) spectroscopy correlates with cerebral blood flow (CBF) and metabolism imaging in the deep white matter of patients with unilateral chronic major cerebral artery steno-occlusive disease.

Methods

Apparent brain temperature and CBF and metabolism imaging were measured using proton MR spectroscopy and 15O-positron emission tomography (PET), respectively, in 35 patients. A set of regions of interest (ROIs) of 5 × 5 voxels was placed on an MR image so that the voxel row at each edge was located in the deep white matter of the centrum semiovale in each cerebral hemisphere. PET images were co-registered with MR images with these ROIs and were re-sliced automatically using image analysis software.

Results

In 175 voxel pairs located in the deep white matter, the brain temperature difference (affected hemisphere − contralateral hemisphere: ΔBT) was correlated with cerebral blood volume (CBV) (r = 0.570) and oxygen extraction fraction (OEF) ratios (affected hemisphere/contralateral hemisphere) (r = 0.641). We excluded voxels that contained ischemic lesions or cerebrospinal fluid and calculated the mean values of voxel pairs in each patient. The mean ΔBT was correlated with the mean CBF (r = − 0.376), mean CBV (r = 0.702), and mean OEF ratio (r = 0.774).

Conclusions

Apparent brain temperature imaging using multi-voxel proton MR spectroscopy was correlated with CBF and metabolism imaging in the deep white matter of patients with unilateral major cerebral artery steno-occlusive disease.

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Authors and Affiliations

  1. Department of Neurosurgery, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate, 020-8505, Japan

    Takamasa Nanba, Hideaki Nishimoto, Toshiyuki Murakami, Shunrou Fujiwara & Kuniaki Ogasawara

  2. Open and Transdisciplinary Research Initiatives, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Yoshichika Yoshioka

  3. Institute for Biomedical Science, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate, 020-8505, Japan

    Makoto Sasaki & Ikuko Uwano

  4. Cyclotron Research Center, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate, 020-8505, Japan

    Kazunori Terasaki

Authors
  1. Takamasa Nanba
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  2. Hideaki Nishimoto
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  3. Yoshichika Yoshioka
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  4. Toshiyuki Murakami
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  5. Makoto Sasaki
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  6. Ikuko Uwano
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  7. Shunrou Fujiwara
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  8. Kazunori Terasaki
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  9. Kuniaki Ogasawara
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Corresponding author

Correspondence to Kuniaki Ogasawara.

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Funding

This work was funded in part by a Grant-in-Aid for Strategic Medical Science Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (S1491001) and Scientific Research from the Japan Society for the Promotion of Science (JP15K10313).

Conflict of interest

KO has received research funds from Nihon Medi-Physics Co., Ltd. and Bristol-Myers Squibb.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Nanba, T., Nishimoto, H., Yoshioka, Y. et al. Apparent brain temperature imaging with multi-voxel proton magnetic resonance spectroscopy compared with cerebral blood flow and metabolism imaging on positron emission tomography in patients with unilateral chronic major cerebral artery steno-occlusive disease. Neuroradiology 59, 923–935 (2017). https://doi.org/10.1007/s00234-017-1890-3

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  • DOI: https://doi.org/10.1007/s00234-017-1890-3

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