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Analysis of heat-induced contaminants (acrylamide, chloropropanols and furan) in carbohydrate-rich food

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Abstract

Heat-induced food contaminants have attracted attention of both the scientific community and the public in recent years. The presence of substances considered possibly or probably carcinogenic to humans has triggered an extensive debate on the healthiness of even staple foods. In that respect, acrylamide, furan and chloropropanols are the main substances of concern. Their widespread occurrence in processed food, which concomitantly causes considerable exposure to humans, led either to the setting of maximum limits (for some chloropropanols) or at least the initiation of monitoring programmes in order to put risk assessment on a solid data basis. Acrylamide, furan and chloropropanols are small molecules with physicochemical properties that make their analysis challenging. Their amount in food ranges typically from below the limit of detection to hundreds of micrograms per kilo or even milligrams per kilo. However, a number of recently published scientific reports deal with the analysis of these substances in different kinds of food. The aim of this publication is to give an overview of analytical approaches for the determination of acrylamide, furan and chloropropanols in foodstuffs.

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References

  1. Velíšek J, Davídek J, Hajšlová J, Kubelka V, Janícek G, Mánková B (1978) Z Lebensm Unters Forsch 167:241–244

    Google Scholar 

  2. Swedish National Food Administration (2002) Information about acrylamide in food, April 24, 2002, http://www.slv.se

  3. http://www.cfsan.fda.gov/~dms/furandat.html. Cited 20 Jan 2007

  4. Kasamatsu T, Kohda K (2006) Regul Toxicol Pharmacol 46:100–104

    CAS  Google Scholar 

  5. IARC Monographs on the evaluation of carcinogenic risks to humans: some industrial chemicals (1994) International Agency for Research on Cancer, Vol 60, IARC, France, 1994

  6. IARC Monographs on the evaluation of carcinogenic risks to humans (1995) International Agency for Research on Cancer, Vol 63, IARC, France, 1995

  7. Opinion of the Scientific Committee on Food on 3-monochloro-propane-1,2-diol (3-MCPD), SCF/CS/CNTM/OTH/17 Final, 30 May 2001

  8. Commission Directive 2001/22/EC (2001) Official J Eur Commun L77:14

    Google Scholar 

  9. Joint FAO/WHO experts committee on food additives (2005) summary and conclusions of the sixty-fourth meeting of the Joint FAO/WHO experts committee on food additives (JECFA), JECFA/64/SC

  10. Boon PE, De Mul A, Van Der Voet H, Van Donkersgoed G, Brette M, Van Klaveren JD (2005) Mutat Res 580:143–155

    CAS  Google Scholar 

  11. Matthys C, Bilau M, Govaert Y, Moons E, De Henauw S, Willems JL (2005) Food Chem Toxicol 43:271–278

    CAS  Google Scholar 

  12. Fohgelberg P, Rosen J, Hellenäs K-E, Abramsson-Zetterberg L (2005) Food Chem Toxicol 43:951–959

    CAS  Google Scholar 

  13. Dybing E, Farmer PB, Andersen M, Fennell TR, Lalljie SPD, Müller DJG, Olin S, Petersen BJ, Schlatter J, Scholz G, Scimeca JA, Slimani N, Toernqvist M, Tuijtelaars S, Verger P (2005) Food Chem Toxicol 43:365–410

    CAS  Google Scholar 

  14. Rice JM (2005) Mutat Res 580:3–20

    CAS  Google Scholar 

  15. Pelucchi C, Galeone C, Levi F, Negri E, Franceschi S, Talamini R, Bosetti C, Giacosa A, La Vecchia C (2006) Int J Cancer 118:467–471

    CAS  Google Scholar 

  16. Jägerstad M, Skog K (2005) Mutat Res 574:156–172

    Google Scholar 

  17. Yaylayan VA, Stadler RH (2005) J AOAC Int 88:262–267

    CAS  Google Scholar 

  18. Granvogl M, Jezussek M, Koehler P, Schieberle P (2004) J Agric Food Chem 52:4751–4757

    CAS  Google Scholar 

  19. Granvogl M, Schieberle P (2006) J Agric Food Chem 54:5933–5938

    CAS  Google Scholar 

  20. Goldmann T, Perisset A, Bertholet M-C, Stadler RH, Petersson EV, Hellenäs K-E (2006) Food Addit Contam 23:437–445

    CAS  Google Scholar 

  21. Mestdagh F, De Meulenaer B, Van Peteghem C (2007) Food Chem 100:1153–1159

    CAS  Google Scholar 

  22. Gertz C, Klostermann S (2002) Eur J Lipid Sci Technol 104:762–771

    CAS  Google Scholar 

  23. http://www.irmm.jrc.be/html/activities/acrylamide/index.htm. Cited 20 Jan 2007

  24. Lineback D, Wenzl T, Ostermann OP, De La Calle B, Anklam E, Taeymans D (2005) J AOAC Int 88:246–252

    CAS  Google Scholar 

  25. Wenzl T, Anklam E (2007) Food Addit Contam (in press)

  26. Wenzl T, de la Calle MB, Anklam E (2003) Food Addit Contam 20:885–902

    CAS  Google Scholar 

  27. Castle L, Eriksson S (2005) J AOAC Int 88:274–284

    CAS  Google Scholar 

  28. Zhang Y, Zhang G, Zhang Y (2005) J Chromatogr A 1075:1–21

    CAS  Google Scholar 

  29. Rosen J, Hellenäs K-E (2002) Analyst 127:880–882

    CAS  Google Scholar 

  30. Wenzl T, Karasek L, Rosen J, Hellenäs K-E, Crews C, Castle L, Anklam E (2006) J Chromatogr A 1132:211–218

    CAS  Google Scholar 

  31. Biedermann M, Biedermann-Brem S, Noti A, Grob K, Egli P, Mändli H (2002) Mitt Lebensm Hyg 93:638–652

    CAS  Google Scholar 

  32. Wenzl T, De La Calle B, Gatermann R, Hoenicke K, Ulberth F, Anklam E (2004) Anal Bioanal Chem 379:449–457

    CAS  Google Scholar 

  33. Weisshaar R (2004) Eur J Lipid Sci Technol 106:786–792

    CAS  Google Scholar 

  34. Castle L, Campos M-J, Gilbert J (1991) J Sc Food Agric 54:549–555

    CAS  Google Scholar 

  35. Castle L (1993) J Agric Food Chem 41:1261–1263

    CAS  Google Scholar 

  36. Nemoto S, Takatsuki S, Sasaki K, Maitani T (2002) J Food Hygien Soc Japan 43:371–376

    CAS  Google Scholar 

  37. Wenzl T, Musser S, Ulberth F, Anklam E (2004) Detailed report on the second European inter-laboratory comparison study on the determination of acrylamide in food-acrylamide in crispbread samples, EUR 21272 EN

  38. Petersson EV, Rosen J, Turner C, Danielsson R, Hellenäs K-E (2006) Anal Chim Acta 557:287–295

    CAS  Google Scholar 

  39. Eriksson S, Karlsson P (2006) Food Sci Technol 39:392–398

    Google Scholar 

  40. Grob K, Biedermann M, Hoenicke K, Gatermann R (2004) Analyst 129:92

    CAS  Google Scholar 

  41. DeVries JW, Post BE (2004) Analyst 129:93–95

    CAS  Google Scholar 

  42. Tanaka M, Yoneda Y, Terada Y, Endo E, Yamada T (2004) Analyst 129:96–98

    CAS  Google Scholar 

  43. Gökmen V, Şenyuva HZ (2006) J Chromatogr A 1120:194–198

    Google Scholar 

  44. Mastovska K, Lehotay SJ (2006) J Agric Food Chem 54:7001–7008

    CAS  Google Scholar 

  45. Yusà V, Quintás G, Pardo O, Martí P, Pastor A (2006) Food Addit Contam 23:237–244

    Google Scholar 

  46. Roach JAG, Andrzejewski D, Gay ML, Nortrup D, Musser SM (2003) J Agric Food Chem 51:7547–7554

    CAS  Google Scholar 

  47. Jiao J, Zhang Y, Ren Y, Wu X, Zhang Y (2005) J Chromatogr A 1099:198–202

    CAS  Google Scholar 

  48. Lee M-R, Chang L-Y, Dou J (2007) Anal Chim Acta 582:19–23

    CAS  Google Scholar 

  49. Hoenicke K, Gatermann R, Harder W, Hartig L (2004) Anal Chim Acta 520:207–215

    CAS  Google Scholar 

  50. Dunovská L, Cajka T, Hajšlová J, Holadová K (2006) Anal Chim Acta 578:234–240

    Google Scholar 

  51. Zhang Y, Ren Y, Zhao H, Zhang Y (2007) Anal Chim Acta (in press)

  52. Zhang Y, Dong Y, Ren Y, Zhang Y (2006) J Chromatogr A 1116:209–216

    CAS  Google Scholar 

  53. Bermundo E, Moyano E, Puignou L, Galceran MT (2006) Anal Chim Acta 559:207–214

    Google Scholar 

  54. Senyuva HZ, Gökmen V (2005) Food Addit Contam 22:204–209

    CAS  Google Scholar 

  55. Rufián-Henares JA, Morales FJ (2006) Food Chem 97:555–562

    Google Scholar 

  56. Murkovic M (2004) J Biochem Biophys Methods 61:161–167

    CAS  Google Scholar 

  57. Commission Decision 2002/657/EC (2002) Off J Eur Commun L 221:8

    Google Scholar 

  58. Gökmen V, Şenyuva HZ, Acar J, Sarioglu K (2005) J Chromatogr A 1088:193–199

    Google Scholar 

  59. Paleologos EK, Kontominas MG (2005) J Chromatogr A 1077:128–135

    CAS  Google Scholar 

  60. Casella IG, Pierri M, Contursi M (2006) J Chromatogr A 1107:198–203

    CAS  Google Scholar 

  61. Bermudo E, Nunez O, Puignou L, Galceran MT (2006) J Chromatogr A 1120:199–204

    CAS  Google Scholar 

  62. Bermudo E, Nunez O, Puignou L, Galceran MT (2006) J Chromatogr A 1129:129–134

    CAS  Google Scholar 

  63. Zhou Y, Fan L-Y, Zhang W, Cao C-X Talanta (2007) 584:322–332

  64. Sagratini G, Fabbri A, Marucci G, Ricciutelli M, Vittori S, Ammendola S (2007) Food Contr 18:1267–1271

    Google Scholar 

  65. Stobiecka A, Radecka H, Radecki (2007) J Biosens Bioelectr 22:2165–2170

    CAS  Google Scholar 

  66. Kleefisch G, Kreutz C, Bargon J, Silva G, Schalley CA (2004) Sensors 4:136–146

    CAS  Google Scholar 

  67. Calta P, Velíšek J, Doležal M, Hasnip S, Crews C, Réblová Z (2004) Eur Food Res Technol 218:501–506

    CAS  Google Scholar 

  68. Tritscher AM (2004) Toxicol Lett 149:177–186

    CAS  Google Scholar 

  69. Lynch BS, Bryant DW, Hook GJ, Nestmann ER, Munro IC (1998) Int J Toxicol 17:47–76

    CAS  Google Scholar 

  70. Crews C, LeBrun G, Brereton PA (2002) Food Addit Contam 19:343–349

    CAS  Google Scholar 

  71. Brereton P, Kelly J, Crews C, Honour S, Wood R, Davies A (2001) J AOAC Int 84:455–465

    CAS  Google Scholar 

  72. Hamlet CG, Sadd PA, Crews C, Velíšek J, Baxter DE (2002) Food Addit Contam 19:619–631

    CAS  Google Scholar 

  73. Hamlet CG, Jayaratne SM, Matthews W (2002) Food Addit Contam 19:15–21

    CAS  Google Scholar 

  74. Breitling-Utzmann CM, Kobler H, Herbolzheimer D, Maier A (2003) Deut Lebensm-Rdsch 99:280–285

    CAS  Google Scholar 

  75. Crews C, Brereton P, Davies A (2001) Food Addit Contam 18:271–280

    CAS  Google Scholar 

  76. Hamlet CG, Sadd PA (2002) Eur Food Res Technol 215:46–50

    CAS  Google Scholar 

  77. Hamlet CG, Sadd PA, Gray DA (2003) Eur Food Res Technol 216:122–128

    CAS  Google Scholar 

  78. Velíšek J, Calta P, Crews C, Hasnip S, Doleal M (2003) Czech J Food Sci 21:153–161

    Google Scholar 

  79. Doleal M, Calta P, Velíšek J (2004) Czech J Food Sci 22:263–266

    Google Scholar 

  80. Hamlet CG, Sadd PA, Gray DA (2004) J Agric Food Chem 52:2059–2066

    CAS  Google Scholar 

  81. Hamlet CG, Sadd PA, Gray DA (2004) J Agric Food Chem 52:2067–2072

    CAS  Google Scholar 

  82. Robert MC, Oberson JM, Stadler RH (2004) J Agric Food Chem 52:5102–5108

    CAS  Google Scholar 

  83. Hamlet CG, Sadd PA (2005) Food Addit Contam 22:616–623

    CAS  Google Scholar 

  84. Breitling-Utzmann CM, Hrenn H, Haase NU, Unbehend GM (2005) Food Addit Contam 22:97–103

    CAS  Google Scholar 

  85. Muller RE, Booer CD, Slaiding IR, Baxter ED (2005) Proceedings of the Congress-European Brewery Convention 30th:167-1-167/12

  86. Kuntzer J, Weisshaar R (2006) Deut Lebensm-Rdsch 102:397–400

    CAS  Google Scholar 

  87. Svejkovská B, Novotný O, Divinová V, Réblová Z, Doleal M, Velíšek J (2004) Czech J Food Sci 22:190–196

    Google Scholar 

  88. Hamlet CG, Sadd PA (2004) Czech J Food Sci 22:259–262

    CAS  Google Scholar 

  89. Kissa E (1992) J Chromatogr 605:134–138

    CAS  Google Scholar 

  90. Rodman LE, Ross RD (1986) J Chromatogr 369:97–103

    CAS  Google Scholar 

  91. Wittmann R (1991) Z Lebensm Unters Forsch 193:224–229

    CAS  Google Scholar 

  92. Spyres G (1993) J Chromatogr 638:71–74

    CAS  Google Scholar 

  93. van Rillaer W, Beernaert H (1989) Z Lebensm Unters Forsch 188:343–345

    Google Scholar 

  94. Nyman PJ, Diachenko GW, Perfetti GA (2003) Food Addit Contam 20:903–908

    CAS  Google Scholar 

  95. Xing X, Cao Y (2007) Food Control 18:167–172

    Article  CAS  Google Scholar 

  96. Bodén L, Lundgren M, Stensiö KE, Gorzynski M (1997) J Chromatogr A 788:195–203

    Google Scholar 

  97. Schurig V, Wistuba D (1984) Tetrahed Lett 25:5633–5636

    CAS  Google Scholar 

  98. Pesselman RL, Feit MJ (1988) J Chromatogr 439:448–452

    CAS  Google Scholar 

  99. Plantinga WJ, van Toorn WG, van der Stegen GHD (1991) J Chromatogr 555:311–314

    CAS  Google Scholar 

  100. Amtliche Sammlung von Untersuchungsverfahren nach § 35 LMBG (1995) Bestimmung von 3-Chlor-1,2-Propandiol (3-MCPD) in Speisewürzen (Eiweiβhydrolysate). Beuth Verlag, Berlin, Germany

  101. van den Berg T (2002) GIT Labor-Fachzeitschrift 1102–1105

  102. Kuballa T, Ruge W (2003) Lebensmittelchem 57:57–58

    Google Scholar 

  103. Divinová V, Svejkovská B, Doleal M, Velíšek J (2004) Czech J Food Sci 22:182–189

    Google Scholar 

  104. Huang MJ, Jiang GB, He B, Liu JF, Zhou QX, Fu WS, Wu YN (2005) Anal Sci 21:1343–1347

    CAS  Google Scholar 

  105. van Bergen CA, Collier PD, Cromie DDO, Lucas RA, Preston HD, Sissons DJ (1992) J Chromatogr 589:109–119

    Google Scholar 

  106. Hamlet CG (1998) Food Addit Contam 15:451–465

    CAS  Google Scholar 

  107. Hamlet CG, Sutton PG (1997) Rap Commun Mass Spectrom 11:1417–1424

    CAS  Google Scholar 

  108. DIN EN 14573 (2005) Foodstuffs-determination of 3-monochloropropane-1,2-diol by GC/MS. Beuth Verlag, Berlin, Germany

    Google Scholar 

  109. Xu X, Ren Y, Wu P, Han J, Shen X (2006) Food Addit Contam 23:110–119

    CAS  Google Scholar 

  110. Meierhans DC, Bruehlmann S, Meili J, Taeschler C (1998) J Chromatogr A 802:325–333

    CAS  Google Scholar 

  111. Chung WC, Hui KY, Cheng SC (2002) J Chromatogr A 952:185–192

    CAS  Google Scholar 

  112. Bel-Rhlid R, Talmon JP, Fay LB, Juillerat MA (2004) J Agric Food Chem 52:6165–6169

    CAS  Google Scholar 

  113. Abu-El-Haj S, Bogusz MJ, Ibrahim Z, Hassan H, Al Tufail M (2007) Food Control 18:81–90

    CAS  Google Scholar 

  114. Rétho C, Blanchard F (2005) Food Addit Contam 22:1189–1197

    Google Scholar 

  115. Dayrit FM, Niñonuevo MR (2004) Food Addit Contam 21:204–209

    CAS  Google Scholar 

  116. Davídek J, Velíšek J, Kubelka V, Janícek G, Šimicová Z (1980) Z Lebensm Unters Forsch 171:14–17

    Google Scholar 

  117. Matthew BM, Anastasio C (2000) J Chromatogr A 866:65–77

    CAS  Google Scholar 

  118. National Toxicology Program (NTP) (1993) Ninth report on carcinogenesis, furan CAS No. 110-00-9 (carcinogenicity)

  119. Maga JA (1979) CRC Crit Rev Food Sci Nutr 11:355–400

    Article  CAS  Google Scholar 

  120. Locas CP, Yaylayan VA (2004) J Agric Food Chem 52:6830–6836

    CAS  Google Scholar 

  121. Becalski A, Seaman S (2005) J AOAC Int 88:102–106

    CAS  Google Scholar 

  122. Märk J, Pollien P, Lindinger C, Blank I, Märk T (2006) J Agric Food Chem 54:2786–2793

    Google Scholar 

  123. Becalski A, Forsyth D, Casey V, Lau BPY, Pepper K, Seaman S (2005) Food Addit Contam 22:535–540

    CAS  Google Scholar 

  124. Kolb B, Ettre LS (1997) Static headspace-gas chromatography theory and practice. Wiley-VCH, Weinheim

  125. Şenyuva HZ, Gökmen V (2005) Food Addit Contam 22:1198–1202

    Google Scholar 

  126. Hasnip S, Crews C, Castle L (2006) Food Addit Contam 23:219–227

    CAS  Google Scholar 

  127. Ridgway K, Lalljie SPD, Smith RM (2006) J Chromatogr A 1124:181–186

    CAS  Google Scholar 

  128. Bicchi C, Iori C, Rubiolo P, Sandra P (2002) J Agric Food Chem 50:449–459

    CAS  Google Scholar 

  129. Goldmann T, Périsset A, Scanlan F, Stadler RH (2005) Analyst 130:878–883

    CAS  Google Scholar 

  130. Ho IP, Yoo SJ, Tefera S (2005) J AOAC Int 88:574–576

    CAS  Google Scholar 

  131. Bianchi F, Careri M, Mangia A, Musci M (2006) J Chromatogr A 1102:268–272

    CAS  Google Scholar 

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Wenzl, T., Lachenmeier, D.W. & Gökmen, V. Analysis of heat-induced contaminants (acrylamide, chloropropanols and furan) in carbohydrate-rich food. Anal Bioanal Chem 389, 119–137 (2007). https://doi.org/10.1007/s00216-007-1459-9

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