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Region-specific role of Rac in nucleus accumbens core and basolateral amygdala in consolidation and reconsolidation of cocaine-associated cue memory in rats

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Abstract

Rationale and objectives

Drug reinforcement and the reinstatement of drug seeking are associated with the pathological processing of drug-associated cue memories that can be disrupted by manipulating memory consolidation and reconsolidation. Ras-related C3 botulinum toxin substrate (Rac) is involved in memory processing by regulating actin dynamics and neural structure plasticity. The nucleus accumbens (NAc) and amygdala have been implicated in the consolidation and reconsolidation of emotional memories. Therefore, we hypothesized that Rac in the NAc and amygdala plays a role in the consolidation and reconsolidation of cocaine-associated cue memory.

Methods

Conditioned place preference (CPP) and microinjection of Rac inhibitor NSC23766 were used to determine the role of Rac in the NAc and amygdala in the consolidation and reconsolidation of cocaine-associated cue memory in rats.

Results

Microinjections of NSC23766 into the NAc core but not shell, basolateral (BLA), or central amygdala (CeA) after each cocaine-conditioning session inhibited the consolidation of cocaine-induced CPP. A microinjection of NSC23766 into the BLA but not CeA, NAc core, or NAc shell immediately after memory reactivation induced by exposure to a previously cocaine-paired context disrupted the reconsolidation of cocaine-induced CPP. The effect of memory disruption on cocaine reconsolidation was specific to reactivated memory, persisted at least 2 weeks, and was not reinstated by a cocaine-priming injection.

Conclusions

Our findings indicate that Rac in the NAc core and BLA are required for the consolidation and reconsolidation of cocaine-associated cue memory, respectively.

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Acknowledgments

This work was supported by the National Basic Research Program of China (no. 2009CB522004) and the Natural Science Foundation of China (nos. 81201032, 31230033, and 31070958).

Conflict of interest

The authors declare that they do not have any conflicts of interest (financial or otherwise) related to the data presented in this manuscript.

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Authors and Affiliations

  1. National Institute on Drug Dependence, Peking University, 38, Xue Yuan Road, Beijing, 100191, China

    Zeng-Bo Ding, Ping Wu, Yi-Xiao Luo, Hao-Wei Shen, Shen-Jun Wang & Lin Lu

  2. Department of Biochemistry and Molecular Biology, Basic Medical College, Hebei Medical University, Shijiazhuang, 050017, China

    Hai-Shui Shi

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  1. Zeng-Bo Ding
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  2. Ping Wu
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Ding, ZB., Wu, P., Luo, YX. et al. Region-specific role of Rac in nucleus accumbens core and basolateral amygdala in consolidation and reconsolidation of cocaine-associated cue memory in rats. Psychopharmacology 228, 427–437 (2013). https://doi.org/10.1007/s00213-013-3050-8

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