Abstract
Summary
We prospectively investigated related clinical and radiological risk factors for progression following acute osteoporotic spinal fractures. Fracture location, morphological feature (mid-portion), and involvement of vertebral posterior wall were statistical significant risk factors considering increase of height loss and kyphotic angle, and occurrence of intravertebral cleft sign as a progressive collapse.
Introduction
This study was designed to investigate the clinical and radiological risk factors related to progressive collapse of acute osteoporotic spinal fractures (OSF).
Methods
In total, 100 patients with acute OSF were prospectively enrolled at a single institute. Five pathological fractures were excluded. Twelve patients dropped out of the study because of conversion to surgical treatment during follow-up. Eight patients were excluded as follow-up losses. Thus, 75 patients were analyzed. Clinical data and radiological data were recorded and analyzed. As a definition of progressive OSF, height loss ≥15 %, kyphotic angle ≥10°, and the occurrence of an intravertebral cleft sign at the 6-month follow-up compared to the initial values were adopted. Correlation analysis and multiple logistic regression analyses were performed to elucidate the related clinical or radiological factors for progressive OSF.
Results
The occurrence of intravertebral cleft was not related to any significant differences in the clinical results and was only related to the fracture level in the regression analysis. A ≥15 % increase in height loss and a ≥10° increase in kyphotic angle were related to worse clinical results. Mid-portion type fractures and involvement of the posterior wall were significant risk factors with relatively high odds ratios for progressive OSF under these criteria.
Conclusion
A thoracolumbar fracture, a mid-portion type fracture, and involvement of the vertebral posterior wall are relative risk factors for progressive collapse following acute OSF. More attention should be paid to patients with OSF and these risk factors during conservative management.
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Acknowledgments
We would like to express special thanks to Dr. Kim Hyun-Woo and Dr. Lee Ju-Yup for their contribution to clinical data preparation. This study is partially supported by research grant of Dae-woong Pharmacy Co. No other funds or benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this study.
Conflicts of interest
This study is partially supported by research grant of Dae-woong Pharmacy Co.
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Ha, K.Y., Kim, Y.H. Risk factors affecting progressive collapse of acute osteoporotic spinal fractures. Osteoporos Int 24, 1207–1213 (2013). https://doi.org/10.1007/s00198-012-2065-z
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DOI: https://doi.org/10.1007/s00198-012-2065-z