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Insertion/deletion polymorphism in the promoter of NFKB1 influences severity but not mortality of acute respiratory distress syndrome

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Abstract

Objective

This study investigated whether the insertion/deletion polymorphism in the promoter of NFKB1 is associated with severity and/or mortality in ARDS.

Design and setting

Prospective study in a mixed anesthesiological ICU of the University Hospital Essen.

Patients and participants

103 adult patients with ARDS (white Germans).

Measurements and results

Patients with ARDS were genotyped for the insertion/deletion polymorphism in the promoter of NFKB1 (−94ins/delATTG). In ARDS patients genotypes differed significantly between those with severe ARDS [Lung Injury Score (LIS) ≥ 3; 23 homozygote deletion (DD), heterozygote (ID) 31, and homozygote insertion wildtype (II) 23], and those with LIS below 3 (1 DD, 9 ID, 16 II). Likewise, the frequency of the D allele was significantly less in patients with higher LIS (50% D) than lower LIS (21% D). Using these values produces a significantly higher OR of 16.0 (95% CI 1.96–130.9) for DD than for II, while the OR for ID vs. II was 2.4 (95% CI 0.9–6.4). Genotypes of the NFKB1 promoter polymorphism were associated neither with 30-day survival nor with duration of ICU stay.

Conclusions

The insertion/deletion polymorphism in the promoter of NFKB1 influences the severity but not the mortality of ARDS.

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Authors and Affiliations

  1. Institut für Pharmakogenetik, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany

    Michael Adamzik, Ulrich H. Frey, Kathrin Rieman & Winfried Siffert

  2. Klinik für Anästhesiologie und Intensivmedizin, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany

    Michael Adamzik, Ulrich H. Frey, Stephan Sixt, Martin Beiderlinden & Jürgen Peters

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  1. Michael Adamzik
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  2. Ulrich H. Frey
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  3. Kathrin Rieman
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Correspondence to Michael Adamzik.

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Adamzik, M., Frey, U.H., Rieman, K. et al. Insertion/deletion polymorphism in the promoter of NFKB1 influences severity but not mortality of acute respiratory distress syndrome. Intensive Care Med 33, 1199–1203 (2007). https://doi.org/10.1007/s00134-007-0649-4

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  • DOI: https://doi.org/10.1007/s00134-007-0649-4

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