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Mannose-binding lectin deficiency provides a genetic basis for the use of SIRS/sepsis definitions in critically ill patients

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References

  1. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WR, Schein RM, Sibbald WJ (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM consensus conference. Chest 101:1644–1655

    CAS  PubMed  Google Scholar 

  2. Hayden WR (1993) Sepsis and organ failure definitions and guidelines. Crit Care Med 21:1612–1613

    CAS  PubMed  Google Scholar 

  3. Turner MW (1996) Mannose binding lectin: the pluripotent molecule of the innate immune system. Immunol Today 17:532–540

    CAS  PubMed  Google Scholar 

  4. Jack DL, Read RC, Tenner AJ, Frasch M, Turner MW, Klein NJ (2001) Mannose binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria menigitidis serogroup B. J Infect Dis 17:532–540

    Google Scholar 

  5. Sumiya M. Super M, Tabona P, Levinsky RJ, Arai T, Turner MW, Summerfield JA (1991) Molecular basis of opsonic defect in immunodeficient children. Lancet 337:1569–1570

    CAS  PubMed  Google Scholar 

  6. Lipscombe RJ, Sumiya M, Hill AV, Lau YL, Levinsky RJ, Summerfield JA, Turner MW (1992) High frequencies in African and non-African populations of independent mutations in mannose binding protein gene. Hum Mol Genetics 1:709–715

    CAS  Google Scholar 

  7. Madsen HO, Garred P, Kurtzhals JA, Lamm LU, Ryder LP, Thiel S, Svejgaard A (1994) A new frequent allele is the missing link in the structural polymorphism of the human mannose binding protein. Immunogenetics 40:37–47

    Google Scholar 

  8. Fidler KJ, Wilson P, Davies JC, Turner MW, Peters MJ, Klein NJ (2004) Increased incidence and severity of the systemic inflammatory response syndrome in patients deficience in mannose-binding lectin. Intensive Care Med (http://dx.doi.org/10.1007/s00134-004-2303-8

  9. Koch A, Melbye M, Sorensen P, Madsen HO, Molbak K, Hansen CH, Andersen LH, Hahn GW, Garred P (2001) Acute respiratory infection and mannose binding lectin deficiency during early childhood. JAMA 285:1316–1321

    CAS  PubMed  Google Scholar 

  10. Hibberd ML, Sumiya M, Summerhill SA, Booy R, Levin M (1999) Association of variants of the gene for mannose binding lectin with susceptibility to meningococcal disease. Lancet 353:1049–1053

    Article  CAS  PubMed  Google Scholar 

  11. Neth O, Hann I, Turner MW, Klein NJ (2001) Deficiency of mannose binding lectin and burden of infection in children with malignancy: a prospective study. Lancet 358:614–618

    Article  CAS  PubMed  Google Scholar 

  12. Peterslund NA, Koch C, Jensinius JC, Thiel S (2001) Association between deficiency of mannose binding lectin and severe infections after chemotherapy. Lancet 358:637–650

    CAS  PubMed  Google Scholar 

  13. Garred P, Madsen HO, Balslev U, Hofmann B, Pedersen C, Gerstoft J, Svejgaard A (1997) Susceptibility to HIV infection and progression of AIDS in relation to variant alleles of mannose binding lectin. Lancet 349:236–240

    CAS  PubMed  Google Scholar 

  14. Kronborg G, Weis N. Madsen HO, Pederson SS, Wejse C, Nielsen H, Shinhoj P, Garred P (2002) Variant mannose binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients. J Infect Dis 185:1527–1520

    Article  Google Scholar 

  15. Garred P, Strom JJ, Quist L, Taaning E, Madsen HO (2003) Association of Mannose Binding Lectin polymorphisms with sepsis and fatal outcome in patients with systemic inflammatory response syndrome. J Infect Dis 188:1394–1403

    Article  CAS  PubMed  Google Scholar 

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  1. Children’s Hospital Pittburgh, Department of Critical Care Medicine, 3705 5th Avenue, Pittsburgh, PA, 15213, USA

    Joseph A. Carcillo

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  1. Joseph A. Carcillo
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Correspondence to Joseph A. Carcillo.

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Carcillo, J.A. Mannose-binding lectin deficiency provides a genetic basis for the use of SIRS/sepsis definitions in critically ill patients. Intensive Care Med 30, 1263–1265 (2004). https://doi.org/10.1007/s00134-004-2302-9

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